The effect of vitamin D2 supplementation on vitamin D levels in humans: A time and dose–response meta-analysis of randomized controlled trials

Zhou, Fan; Jamilian, Abdolreza; Prabahar, Kousalya; Hernández-Wolters, Benjamin; Kord-Varkaneh, Hamed; Bai, Dunyao

doi:10.1016/j.steroids.2024.109394

Cited by 1 publication

(1 citation statement)

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“…Subgroup analyses revealed that higher doses of vitamin D2 (> 2000 IU/day), shorter treatment durations (≤ 12 weeks), older age (≥ 60 years), and lower baseline 25(OH)D concentrations (< 20 ng/mL) were associated with more significant increases in total vitamin D levels. These findings emphasize the importance of tailoring vitamin D2 supplementation based on patient characteristics and treatment parameters [ 46 ]. In Latin America, ergocalciferol is only accessible in Argentina, Cuba, México, Panamá, and Perú [ 32 ].…”

Section: Recommendationmentioning

confidence: 99%

Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context

Gómez,

Campusano,

Cerdas-P

et al. 2024

Arch Osteoporos

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Introduction These guidelines aim to provide evidence-based recommendations for the supplementation of Vitamin D in maintaining bone health. An unmet need persists in Latin American regarding the availability of clinical and real-world data for rationalizing the use of vitamin D supplementation. The objective of these guidelines is to establish clear and practical recommendations for healthcare practitioners from Latin American countries to address Vitamin D insufficiency in clinical practice. Methods The guidelines were developed according to the GRADE-ADOLOPMENT methodology for the adaptation or adoption of CPGs or evidence-based recommendations. A search for high quality CPGs was complemented through a comprehensive review of recent literature, including randomized controlled trials, observational studies, and systematic reviews evaluating the effects of Vitamin D supplementation on bone health. The evidence to decision framework proposed by the GRADE Working Group was implemented by a panel of experts in endocrinology, bone health, and clinical research. Results The guidelines recommend Vitamin D supplementation for individuals aged 18 and above, considering various populations, including healthy adults, individuals with osteopenia, osteoporosis patients, and institutionalized older adults. These recommendations offer dosing regimens depending on an individualized treatment plan, and monitoring intervals of serum 25-hydroxyvitamin D levels and adjustments based on individual results. Discussion The guidelines highlight the role of Vitamin D in bone health and propose a standardized approach for healthcare practitioners to address Vitamin D insufficiency across Latin America. The panel underscored the necessity for generating local data and stressed the importance of considering regional geography, social dynamics, and cultural specificities when implementing these guidelines.

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Section: Recommendationmentioning

confidence: 99%