The effect of vitamin D supplementation on serum lipids in postmenopausal women with diabetes: A randomized controlled trial

Muñoz-Aguirre, Paloma; Flores, Mario; Macías, Nayeli; Quezada, Amado D; Denova‐Gutiérrez, Edgar; Salmerón, Jorge

doi:10.1016/j.clnu.2014.10.002

Cited by 55 publications

(40 citation statements)

References 25 publications

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“…These data suggest that maintenance of 25(OH)D3 at a high level over an extended period may reduce blood lipids. Consistently with the present results, a previous study has found a reduction in triglycerides but not total cholesterol, low-density lipoproteins or high-density lipoproteins 6 months after the administration of 4000 IU/d of vitamin D [26] . Vitamin D and calcium may increase the oxidation of whole body fat and increase lipolysis [27,28] .…”

Section: Discussionsupporting

confidence: 81%

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Chen

Duan

et al. 2016

Acta Pharmacol Sin

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Aim: To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficiency status. Methods: A total of 28 young subjects (25 to 35 years old) with vitamin D insufficiency status [serum 25(OH)D <30 ng/mL] was recruited in Shanghai, China. The subjects were orally administered a single high dose of vitamin D3 (300 000 IU). Baseline characteristics and blood samples were collected at d 0, 1, 2, 3, 7, 28, 56, 84 and 112 after the intervention. The blood biomarker levels were determined with standardized methods. Results: The intervention markedly increased the blood 25(OH)D3 levels within the first five days (mean T max =5.1±2.1 d) and sustained an optimal circulating level of 25(OH)D3 (≥30 ng/mL) for 56 d. After the intervention, body weight and baseline 25(OH)D3 levels were significantly correlated with circulating 25(OH)D3 levels. No adverse events and no consistently significant changes in serum calcium, creatinine, glucose, parathyroid hormone, vitamin D binding protein, or the urinary calcium/creatinine ratio were observed. However, there was a significant increase in phosphorus after the vitamin D3 intervention. Total cholesterol and triglyceride levels were decreased at the end of the trial. Conclusion: The pharmacokinetics of vitamin D after intervention were influenced by baseline 25(OH)D3 levels and the body weight of the subjects. The results suggest that a single high oral vitamin D3 intervention is safe and efficient for improving the vitamin D status of young Chinese people with vitamin D insufficiency.

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Section: Discussionsupporting

confidence: 81%

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Chen

Duan

et al. 2016

Acta Pharmacol Sin

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“…Our results are also in line with the findings of a 6-month randomised controlled trial (24) in postmenopausal women with type 2 diabetes, which showed that a daily 100 µg *Multivariable-adjusted model 1, adjusted for age, BMI, social class (manual and non-manual workers), alcohol intake (non-drinker, drinker has been divided into three equal groups), smokers (non-smoker, current smoker, previous smoker), leisure activity (yes and no) and food energy intake. †Multivariable-adjusted model 2, additionally adjusted for Ca intake.…”

Section: Discussionsupporting

confidence: 82%

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study

Guo

Cockcroft

Elwood

et al. 2017

Public Health Nutr.

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Objective: Prospective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study. Design: The associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups. In addition, the predictive value of vitamin D intake for CVD events and all-cause mortality after >20 years of follow-up was examined. Logistic regression and general linear regression were used for data analysis. Setting: Participants in the UK. Subjects: Men (n 452) who were free from CVD and type 2 diabetes at recruitment. Results: Higher vitamin D intake was associated with increased HDL cholesterol (P = 0·003) and pulse pressure (P = 0·04) and decreased total cholesterol:HDL cholesterol (P = 0·008) cross-sectionally at baseline, but the associations were lost during follow-up. Furthermore, higher vitamin D intake was associated with decreased concentration of plasma TAG at baseline (P = 0·01) and at the 5-year (P = 0·01), but not the 10-year examination. After >20 years of follow-up, vitamin D was not associated with stroke (n 72), myocardial infarctions (n 142), heart failure (n 43) or all-cause mortality (n 281), but was positively associated with increased diastolic blood pressure (P = 0·03). Conclusions: The study supports associations of higher vitamin D intake with lower fasting plasma TAG and higher diastolic blood pressure. KeywordsVitamin D CVD All-cause mortality Caerphilly Prospective Cohort Study TAG Recently, the UK Scientific Advisory Committee on Nutrition (1) reported that 22-24 % of individuals aged 19-64 years and 17-24 % of those aged ≥65 years in the UK were vitamin D deficient (plasma 25-hydroxycholecalciferol <25 nmol/l).People generally obtain vitamin D from synthesis in the skin due to sunlight UV radiation and/or foods. However, a number of relatively recent lifestyle changes (increased working indoors, sunscreen use), personal characteristics (ageing, skin pigmentation) and geographic reasons (latitude) limit the ability to synthesise adequate vitamin D from sunlight (2) . As a result, vitamin D intake from foods has become more important than previously. This led the Scientific Advisory Committee on Nutrition to recommend a daily vitamin D intake of 10 µg for all adults within the UK (1) . CVD is one of the main causes of morbidity and mortality in the world and there is mounting evidence indicating an association between suboptimal vitamin D status and increased risk of CVD (3)(4)(5)(6) and all-cause mortality (7)(8)(9) . However, few prospective cohort studies have analysed the relationship between vitamin D intake and CVD risk and allcause mortality. In a 10-year cohort of 361 men and 394 women (10) , lower vitamin D intake was associated with an increased risk of stroke, but not myocardial...

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“…These interesting biological effects may indicate that ionized Ca 2+ and 1,25(OH)2D3 are likely to affect human sebocytes in vivo. In vivo effects on sebocyte proliferation and lipogenesis, like the ones detected in the present work, may occur by ionized Ca 2+ serum levels and/or 1,25(OH)2D3 insufficiency or after systemic supplementation (46). The increased ionized Ca 2+ levels detected in the young patients with acne in our clinical study are compatible with the increased sebocyte numbers and reduced apoptosis, which were detected with higher ecCa 2 + concentrations in our in vitro study and the enhanced sebocyte proliferation observed in acne-involved glands (47).…”

Section: Discussionsupporting

confidence: 73%

Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo

Seltmann²,

Abdel-Naser³

et al. 2017

Acta Derm Venerol

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Calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) are promoters of epithelial cell functions; however their effects on sebaceous glands are unknown. In this study, morphology, ultrastructure, cell numbers, lipid synthesis and apoptosis of SZ95 sebocytes were assessed in vitro under different concentrations of extracellular calcium with or without 1,25(OH)2D3. Moreover, serum calcium and 1,25(OH)2D3 levels were assessed in acne and non-acne patients (controls). Under conditions of low extracellular calcium, lipogenesis and cell detachment were observed. Increasing extracellular calcium enhanced sebocyte numbers, induced epithelial morphology and reduced lipogenesis. Moreover, a reduction in extracellular calcium reduced E-cadherin and enhanced caspase 3/7 activity (apoptosis), whereas calcium chelation by EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid) resulted in enhanced lipogenesis. 1,25(OH)2D3 decreased sebaceous lipogenesis, but also induced signs of autophagy. In the clinical study, patients and controls exhibited normal serum calcium levels. Younger acne patients presented lower 1,25(OH)2D3 levels than did older ones. In conclusion, extracellular calcium and 1,25(OH)2D3 regulate sebocyte morphology, increase cell numbers, decrease sebaceous lipogenesis and induce cell autophagy in vitro. The increased ionized calcium and the reduced 1,25(OH)2D3 levels detected in the serum of younger patients with acne may contribute respectively to increased sebaceous gland volume and enhanced lipogenesis.

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The effect of vitamin D supplementation on serum lipids in postmenopausal women with diabetes: A randomized controlled trial

Cited by 55 publications

References 25 publications

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study

Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo

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