The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis

Jamka, Małgorzata; Woźniewicz, Małgorzata; Walkowiak, Jarosław; Bogdański, Paweł; Jeszka, Jan; Stelmach-Mardas, Marta

doi:10.1007/s00394-015-1089-5

Cited by 83 publications

(58 citation statements)

References 56 publications

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“…In addition, Bellia et al [13] had shown this inverse association of 25(OH)D with CRP to exist for obese subjects in a cross sectional study. The conclusion arising from the meta-analysis of vitamin D supplementation trials among overweight and obese individuals by Jamka et al [23] seems to contradict the findings of these observational studies and of the present study that temporal increases in 25(OH)D concentrations are paralleled by decreases in CRP among obese subjects. Jamka et al [23] had observed a reduction in CRP associated with supplementation but this was not statistically significant.…”

Section: Discussioncontrasting

confidence: 99%

“…The conclusion arising from the meta-analysis of vitamin D supplementation trials among overweight and obese individuals by Jamka et al [23] seems to contradict the findings of these observational studies and of the present study that temporal increases in 25(OH)D concentrations are paralleled by decreases in CRP among obese subjects. Jamka et al [23] had observed a reduction in CRP associated with supplementation but this was not statistically significant. One may speculate that this is attributable to sample size and statistical power as the analysis by Jamka et al [23] were based on observations of 1955 subjects from 13 RCTs, whereas the present analyses included observations of 6755 participants.…”

Section: Discussioncontrasting

confidence: 99%

“…Jamka et al [23] had observed a reduction in CRP associated with supplementation but this was not statistically significant. One may speculate that this is attributable to sample size and statistical power as the analysis by Jamka et al [23] were based on observations of 1955 subjects from 13 RCTs, whereas the present analyses included observations of 6755 participants. However, various other differences between the studies exist that may explain the differences in findings.…”

Section: Discussionmentioning

confidence: 96%

“…Randomized controlled trials (RCT) [16,17,18,19,20,21,22] have produced inconsistent findings with respect to the effect of vitamin D supplementation regimens on serum CRP concentrations. A meta-analysis focusing on supplementation trials among overweight and obese individuals concluded the absence of a significant influence of vitamin D supplementation on serum CRP concentrations [23]. A meta-analysis of supplementation trials published since 2010 concluded the presence of such an influence [24], suggesting the influence of vitamin D on CRP may differ by body weight.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

et al. 2016

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The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations, and trials and meta analyses have been inconsistent in their conclusions regarding the effect of vitamin D supplementation on CRP concentrations. These supplementation trials were mostly conducted among patients with more or less inflammatory complications and did not consider potential distinctive effects by weight status. To further our understanding of the potential influences of vitamin D on CRP, we analyzed longitudinal observations of 6755 participants of a preventative health program. On average, serum 25(OH)D concentrations increased from 88.3 to 121.0 nmol/L and those of CRP decreased from 1.7 to 1.6 mg/L between baseline and follow up. Relative to obese participants without temporal increases in 25(OH)D, those who showed improvements of <25, 25–50, 50–75, and more than 75 nmol/L at follow up were 0.57 (95% confidence interval: 0.37–0.88), 0.54 (0.34–0.85), 0.49 (0.30–0.80), and 0.48 (0.29–0.78) times as likely to have elevated CRP concentrations (≥1 mg/L), respectively. These associations were less pronounced and not statistically significant for normal weight and overweight participants. Herewith, the findings suggest that promotion of adequate serum 25(OH)D concentrations among obese individuals along with healthy lifestyles may alleviate the public health burden associated with cardiovascular disease.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

et al. 2016

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“…Vitamin D supplementation at a dosage of 200,000 IU for 4 weeks also reduced inflammatory markers and increased TAC levels in elderly women with vitamin D insufficiency [40]. However, a meta-analysis study conducted by Jamka et al [41] reported that vitamin D supplementation had no significant effect on inflammatory biomarkers in obese and overweight subjects. Supplementation with 50,000 IU vitamin D3 every 14 days for 16 weeks among adult patients with nonalcoholic fatty liver disease did not influence TAC concentrations [42].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2018

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Objective: This study was conducted to evaluate the effects of vitamin D supplementation on the recurrence and metabolic status of patients with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). Methods: This randomized, double-blind, placebo-controlled trial was carried out among 58 women diagnosed with CIN2/3. Participants were randomly assigned into 2 groups to receive either 50,000 IU vitamin D3 (n = 29) or placebo (n = 29) every 2 weeks for 6 months. Results: The recurrence rate of CIN1/2/3 was 18.5 and 48.1% in the vitamin D and placebo groups respectively (p = 0.02). When we excluded CIN1, the recurrence rate of CIN2/3 became nonsignificant. Vitamin D supplementation significantly decreased fasting plasma glucose (–7.8 ± 9.2 vs. –1.1 ± 8.6 mg/dL, p = 0.006) and insulin levels (–3.2 ± 4.8 vs. –0.9 ± 3.4 µIU/mL, p = 0.03), and significantly increased quantitative insulin sensitivity check index (0.01 ± 0.02 vs. 0.002 ± 0.01, p = 0.02) compared with the placebo. Additionally, there was a significant decrease in high-sensitivity C-reactive protein (–815.3 ± 1,786.2 vs. 717.5 ± 1,827.3 ng/mL, p = 0.002) and a significant increase in total antioxidant capacity (113.4 ± 137.4 vs. –53.7 ± 186.7 mmol/L, p < 0.001) following the supplementation of vitamin D compared with the placebo. Conclusions: Vitamin D3 supplementation for 6 months among women with CIN2/3 had beneficial effects on CIN1/2/3 recurrence and metabolic status; however, it did not affect CIN2/3 recurrence.

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Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice

Valle

Mitchell

Pilon

et al. 2021

Obesity

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Objective This study investigated the effects of a low‐dose salmon peptide fraction (SPF) and vitamin D3 (VitD3) in obese and VitD3‐deficient mice at risk of metabolic syndrome (MetS). Methods Obese and VitD3‐deficient low‐density lipoprotein receptor (LDLr)−/−/apolipoprotein B100 (ApoB)100/100 mice were treated with high‐fat high‐sucrose diets, with 25% of dietary proteins replaced by SPF or a nonfish protein mix (MP). The SPF and MP groups received a VitD3‐deficient diet or a supplementation of 15,000 IU of VitD3 per kilogram of diet. Glucose homeostasis, atherosclerosis, nonalcoholic fatty liver disease, and gut health were assessed. Results VitD3 supplementation increased plasma 25‐hydroxyvitamin D to optimal status whereas the VitD3‐deficient diet maintained moderate deficiency. SPF‐treated groups spent more energy and accumulated less visceral fat in association with an improved adipokine profile. SPF lowered homeostatic model assessment of insulin resistance compared with MP, suggesting that SPF can improve insulin sensitivity. SPF alone blunted hepatic and colonic inflammation, whereas VitD3 supplementation attenuated ileal inflammation. These effects were associated with changes in gut microbiota such as increased Mogibacterium and Muribaculaceae. Conclusions SPF treatment improves MetS by modulating hepatic and gut inflammation along with gut microbiota, suggesting that SPF operates through a gut‐liver axis. VitD3 supplementation has limited influence on MetS in this model.

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The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis

Abstract: This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.

Cited by 83 publications

References 56 publications

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice

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