The effect of vitamin D supplementation on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: A protocol for systematic review and meta-analysis

Chai, Xuxia; Jin, Yonghe; Wang, Yongmei; Yang, Rong

doi:10.1097/md.0000000000032254

Cited by 3 publications

(3 citation statements)

References 18 publications

(20 reference statements)

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“…The mechanisms involved include elevating the levels of anti-inflammatory cytokines while lowering the levels of proinflammatory cytokines. It is also indicated as a therapeutic option in the management of diabetes mellitus [ 160 , 161 ] and skin diseases [ 162 ]. Cheng et al [ 163 ] conducted a systematic review and randomized control trial and observed that vitamin D can reduce negative emotions.…”

Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…At the same time, there is consensus about the beneficial effect of vitamin D on peripheral artery disease, foot ulceration prevention, and wound healing. Vitamin D plays a vital role on indexes of insulin and lipid profile through its impact on activating insulin receptor expression [6].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Vitamin D Level and Its Relation to Glycemic Control Among Patients with Type 2 Diabetes Mellitus in Khartoum State

Abdoalnasir Abdoalrasol Abdallah,

Ahmed Elrheima Ahmed

2023

Sudan JMS

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Background: Type II diabetes is a chronic hyperglycemic disorder. Vitamin D appears to be associated with chronic disease prevention and modulation of immunity. This study was designed to associate vitamin D levels with glycemic control among type 2 diabetes mellitus in Khartoum state. Methods: This was a prospective case-control study conducted between June and November 2021 in Khartoum, Sudan. In total, 80 individuals were included in the study, of which 40 had type 2 diabetes mellitus, while the other 40 were normal, apparently healthy individuals. Vitamin D was measured by ELISA. Results: SPSS was used for statistical analysis. Results showed that 20% of the case group (patients with diabetes mellitus) had suboptimal vitamin D levels, whereas 80% had vitamin D deficiency. Vitamin D levels were significantly decreased among the case group when compared to the control group (P-value = 0.00). The glycated hemoglobin was negatively correlated with vitamin D level (P-value = 0.017, R = –0.376). Conclusion: In this study, a significant decrease in vitamin D was seen among people with type 2 DM. There was a weak negative correlation between hemoglobin A1C and vitamin D levels, and no significant difference in Vitamin D levels among gender and different types of treatment.

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“…In other words, the causal relationship between serum levels of carotenoids and CVD prevalence has not been fully understood. Additionally, other dietary or environmental factors (e.g., artificial sweeteners, vitamin D, dietary fiber, and heavy metals) may still have influences on the conclusions even after model adjustment as carotenoids are mainly obtained from fruits and vegetables (41)(42)(43)(44). The limitations of the WQS regression analysis may also affect the conclusions as the all-positive and all-negative dependent variables have the same effects on exposure.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population

et al. 2023

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BackgroundCardiovascular disease (CVD) has become a key global health issue. Serum carotenoids are associated with CVD, while their effects on different diseases remain unclear. Herein, the relationship between the concentration of serum carotenoid and the CVD risk was investigated using nationwide adult samples obtained from the USA.Materials and methodsData of National Health and Nutrition Examination Survey (NHANES) in 2001–2006 were employed. The association of serum carotenoids (total, lycopene, β-carotene, α-carotene, lutein/zeaxanthin, and β-cryptoxanthin) with CVD was explored by using multivariate logistic, linear and weighted quantile sum (WQS) regression analyses. Eventually, data from 12,424 volunteers were analyzed for this study.ResultsMultivariate model data showed that lutein/zeaxanthin, α-carotene, lycopene, and β-cryptoxanthin were negatively associated with the prevalence of CVD (p < 0.05). In comparison with the first quartile, the fourth quartile was associated with α-carotene ([OR] = 0.61 [0.47–0.79]), β-cryptoxanthin (OR = 0.67 [0.50–0.89]), lutein (OR = 0.69 [0.54–0.86]), and lycopene (OR = 0.53 [0.41–0.67]). WQS analysis revealed that the combination of serum carotenoids had negative correlation with the prevalence of total CVD (OR = 0.88, 95% CI: 0.85–0.92, p < 0.001). Additionally, dose–response analysis demonstrated a negative linear association of hypertension with all the carotenoids involved (p > 0.05 for non-linearity).ConclusionThe concentration of serum carotenoids had negative correlation with the prevalence of CVD, with a more significant negative effect against heart attack and stroke.

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The effect of vitamin D supplementation on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: A protocol for systematic review and meta-analysis

Cited by 3 publications

References 18 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Assessment of Vitamin D Level and Its Relation to Glycemic Control Among Patients with Type 2 Diabetes Mellitus in Khartoum State

The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population

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