The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis

Xu, Yunbao; Qian, Mingxia; Hong, Jiaze; Ng, Derry Minyao; Yang, Tong; Xu, Liuhong; Xia, Ye

doi:10.1007/s00384-021-03879-w

Cited by 15 publications

(4 citation statements)

References 62 publications

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“…Since 􏽢 X(t) reflects the change trend of the amplitude of human motion acceleration, the posterior value 􏽢 X(t) tends to be constant in a steady state. According to the change of the posterior value 􏽢 X(t) in the filtering process, it is judged whether the state of the human body is [20].…”

Section: Health Monitoring Systemmentioning

confidence: 99%

Sports-Induced Fatigue Recovery of Competitive Aerobics Athletes Based on Health Monitoring

Wang

2022

Computational Intelligence and Neuroscience

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Exercise-induced fatigue refers to the symptom that the body cannot continue to maintain the original training volume after a certain period of continuous training. Competitive aerobics athletes have a large amount of daily training exercise, and their bodies are prone to exercise fatigue. The health monitoring technology can monitor the physical state in real time and diagnose and treat the diseases caused by the body in time. This article aims at applying the health monitoring technology to the research of sports fatigue recovery of competitive aerobics athletes. This article first briefly introduces the theoretical review of exercise-induced fatigue, and it includes the definition, classification, and determination methods of exercise-induced fatigue, and then uses the health monitoring system to describe it, and finally conducts an experiment in the diagnosis and rehabilitation of exercise-induced fatigue. The health monitoring technology was compared with traditional medical methods, and the four aspects of speed, accuracy, recovery rate, and athlete’s treatment satisfaction were tested. The experimental results show that the diagnostic accuracy based on health monitoring technology is the same as that of traditional manual medical diagnosis, reaching about 85%, which verifies its effectiveness.

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Section: Health Monitoring Systemmentioning

confidence: 99%

Sports-Induced Fatigue Recovery of Competitive Aerobics Athletes Based on Health Monitoring

Wang

2022

Computational Intelligence and Neuroscience

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“…The effects of vitamin D supplementation on cancer incidence and related mortality are conflicting. Vitamin D supplementation (at doses of 400 IU/day to 100,000 IU/4 months, mostly 2000 IU/day) may reduce the incidence (OR 0.87, 95% CI 0.82-0.92) and extend survival in patients with colorectal cancer (proportion of patients with VDD across studies: 13-99%) [101,102].…”

Section: Cancermentioning

confidence: 99%

Vitamin D, Menopausal Health and COVID-19: Critical Appraisal of Current Data

Anagnostis

Livadas

Goulis

et al. 2023

JCM

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Inconsistency exists across studies conducted in postmenopausal women regarding the effect of vitamin D deficiency (VDD) and supplementation on several aspects of menopausal health, such as fractures, vasomotor symptomatology, cardiovascular disease (CVD), cancer and infections, including coronavirus disease 2019 (COVID-19). The aim of this review is to critically summarize the evidence provided by observational studies and randomized controlled trials (RCTs) of vitamin D supplementation in postmenopausal women with VDD. Observational studies have found that VDD is associated with an increased risk of falls and fractures after the menopause. VDD also has a negative effect on menopausal symptomatology. VDD, especially its severe form, is associated with an increased risk of CVD risk factors and CVD events. VDD is associated with increased risk and mortality from several cancer types and risk of infections. The evidence from RCTs regarding the effect of vitamin D supplementation on falls, fractures, menopausal symptoms, cardiovascular disease, cancer and infections is not robust. Thus, skeletal health may benefit only when vitamin D is co-administered with calcium, especially in those ≥70 years old and with severe VDD. There is no evidence of a favorable effect on menopausal symptoms or risk of CVD or cancer, except for a modest reduction in cancer-related mortality. Inconsistency still exists regarding its effect on infection risk, disease severity and mortality due to COVID-19.

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“…The sample sizes of the studies varied between 1,902 and 1,566,662. Of these meta-analyses, 20 studies [12][13][14]18,21,22,36,37,40,42,[44][45][46][47][48]53,54,57,59,60] reported risk for total cancer and various cancer types, three studies [49,50,52] reported mortality, and 12 studies [19,20,23,24,38,39,41,43,51,55,56,58] reported both mortality and risk. In eight meta-analyses [18,19,20,39,41,56,58,60], the primary studies consisted of RCTs.…”

Section: Baseline Characteristics Of the Meta-analysesmentioning

confidence: 99%

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Arayıcı¹,

Başbınar²,

Ellıdokuz³

2023

Preprint

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It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were included in this study. In the pooled analysis, higher Vit-D intake and serum 25(OH)D levels were associated with lower cancer risk (OR = 0.93, 95% CI: 0.90-0.96, p < 0.001; OR = 0.80, 95% CI: 0.72-0.89, p < 0.001, respectively) and cancer-related mortality (RR = 0.89, 95% CI: 0.86-0.93, p < 0.001; RR = 0.67, 95% CI: 0.58-0.78, p < 0.001, respectively). When meta-analyses whose primary reports included only randomized controlled trials were pooled, there was no significant association between Vit-D intake and cancer risk (OR = 0.99, 95% CI: 0.97-1.01, p = 0.320). In subgroup analysis, Vit-D consumption was associated with a significant decrease in colorectal and lung cancer incidence (OR = 0.89, 95% CI: 0.83-0.96, p = 0.002; OR = 0.88, 95% CI: 0.83-0.94, p < 0.001, respectively). Taken together, both Vit-D intake and higher 25(OH)D levels may provide remarkable benefits in terms of cancer incidence and mortality, however, careful evaluation according to cancer types is critically important and recommended.

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The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis

Cited by 15 publications

References 62 publications

Sports-Induced Fatigue Recovery of Competitive Aerobics Athletes Based on Health Monitoring

Sports-Induced Fatigue Recovery of Competitive Aerobics Athletes Based on Health Monitoring

Vitamin D, Menopausal Health and COVID-19: Critical Appraisal of Current Data

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

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