The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: a systematic review and a meta-analysis

Wang, Su; Wu, Yaping; Zuo, Zhihua; Zhao, Yijing; Wang, Kun

doi:10.1007/s12020-018-1532-5

Cited by 52 publications

(47 citation statements)

References 29 publications

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“…In a systematic review and meta-analysis, Wang et al concluded that supplementation with VitD appeared to significantly reduce levels of anti-TPO (for treatments ≥6 months) and anti-Tg, with no reported serious adverse effects [97]. More recently, Koehler et al retrospectively analyzed 933 patients with autoimmune thyroiditis and found a greater reduction in anti-TPO levels in a 58-patient sub-group that had an improvement in their initially insufficient VitD level (<30 ng/mL) vs. a control group that maintained a VitD level below the threshold.…”

Section: Relevance Of Supplementationmentioning

confidence: 99%

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

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Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

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Section: Relevance Of Supplementationmentioning

confidence: 99%

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

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“…[48] In a meta-analysis comprising of 6 RCTs and involving 344 patients with AITD, Vitamin D supplementation was associated with significant reductions in TPOAb and TgAb titers at 6 months follow-up. [49] In a RCT involving 251 apparently healthy individuals, low dose vitamin supplementation (400 IU/day and 1000 IU/day) as compared to placebo did not result in any significant change in TPOAb and TSH titers at 16 weeks of follow-up. [50] Limitations of this study include the fact that most of the patients in these studies were healthy individuals without AITD and had TPOAb titers in the normal range.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Dutta

Sharma

Aggarwal

et al. 2019

Indian J Endocr Metab

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Background and Aims:In spite of large volume of data linking Vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, Vitamin D and thyroid is a lesser-known aspect of Vitamin D in clinical practice. This article intends to highlight the current literature on the impact of Vitamin D status and supplementation on thyroid autoimmunity and cancer.Methods:References for this review were identified through searches of PubMed for articles published to from 1950 to August 2019 using the terms “thyroid” [MeSH Terms] AND “Vitamin D” [MeSH Terms] OR “thyroid” [All Fields] AND “Vitamin D” [All Fields].Results:Significant inverse correlation was documented between anti-thyroid peroxidase antibody (TPOAb) and serum 25-hydroxy-Vitamin D (25OHD). TPOAb positivity is more prevalent in Vitamin D deficient individuals. A large volume of medical literature is available from observational studies linking Vitamin D with thyroid autoimmunity. Data from interventional studies documenting beneficial effects of Vitamin D on thyroid autoimmunity is also available, but lesser than that from observational studies. Short-term high dose oral Vitamin D supplementation reduces TPOAb titers. Certain Vitamin D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders (AITD). Vitamin D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of Vitamin D and its analogues for treating thyroid cancer.Conclusion:In spite of large volume of medical literature from observational studies linking Vitamin D with thyroid autoimmunity and cancer, meaningful concrete clinical data on impact of Vitamin D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.

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“…A recent meta-analysis including 6 RCT conducted by Wang et al in patients with AITDs found that 6-months VD supplementation significantly decreased TPO-Ab (3 studies, standardized mean difference [SMD]: -1.11, 95% CI -1.52 to -0.70, P <0.01) and TG-Ab titers (SMD: -0.12, 95% CI: -0.69 to 0.44, P = 0.67) compared with controls [38].…”

Section: Vitamin D Supplementation Thyroid and Immune Functions In Hmentioning

confidence: 98%

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

Ihnatowicz¹,

Wątor²,

Drywień³

2019

JFNR

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This review aims to present the importance of nutrients for thyroid health in light of autoimmune Hashimoto's disease. Authors focus mainly on vitamin D and selenium function in the body, metabolism, serum concentration in patients, replenishment outcome after singular or combined the treatment and dose. Vitamin D is essential for immune regulation and yields inflammatory properties. Selenium plays an important role in thyroid metabolism by protecting it from oxidative damage during iodine metabolism and by taking part in thyroid hormone production. Hashimoto is a complex disease and cross-curricular therapies probably will find more interest than oneway therapy.

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The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: a systematic review and a meta-analysis

Cited by 52 publications

References 29 publications

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Supplementation in Autoimmune Thyroid Hashimoto’s Disease. Vitamin D and Selenium

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