The Effect of Vitamin D Supplementation on Breast Density Changes: A Clinical Trial Study

Alipour, Sadaf; Shirzad, Nooshin; Sepidarkish, Mahdi; Saberi, Azin; Bayani, Leila; Hosseini, Ladan

doi:10.1080/01635581.2018.1446088

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Low levels of serum Vitamin D have been assumed as a risk factor for endometriosis and for increased MBD. However, this relation has been highly demonstrated for the former [ 29 ], but not in the latter condition [ 30 ]. Also, use of dairy products might lower the risk of endometriosis [ 31 ], while the few studies about the association of these products with MBD have showed controversial results from no relation to a negative association [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

et al. 2022

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Background Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD. Methods This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables. Results The mean age of all participants was 47.2 ± 6.4 years, and most participants (76.8%) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P value = 0.002), history of progesterone consumption (P value = 0.004) and endometriosis (P value = 0.006) were independent factors for MBD. Conclusion This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

et al. 2022

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“…In addition, in the present study, we found a marginally significant increasing breast density with vitamin D intake (p-value = 0.047). The association between vitamin D and MBD remains poorly understood in many studies [43][44][45] due to differences in study designs, MBD assessment, vitamin D exposure assessment methods, categorization of women with some variables such as menopause, lack of attention to seasonal variation, diet, and other considerations. Since the vitamin D intake in this study was based on the self-reported of women and finding an association between vitamin D intake and breast density was not our goal, this result may be crude and inaccurate.…”

Section: Discussionmentioning

confidence: 99%

Air pollution exposure and mammographic breast density in Tehran, Iran: a cross-sectional study

Eslami

Alipour

Omranipour

et al. 2022

Environ. Health Prev. Med.

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Background: Air pollution is one of the major public health challenges in many parts of the world possibly has an association with breast cancer. However, the mechanism is still unclear. This study aimed to find an association between exposure to six criteria ambient air pollutants (PM 2.5 , PM 10 , SO 2 , NO 2 , O 3 , and CO) and mammographic breast density (MBD), as one of the strongest predictors for developing breast cancer, in women living in Tehran, Iran. Methods: Participants were selected from women attending two university hospitals for screening mammography from 2019 to 2021. Breast density was rated by two expert radiologists. Individual exposures to 3-year ambient air pollution levels at the residence were estimated.Results: The final analysis in 791 eligible women showed that low and high breast density was detected in 34.8 and 62.2 of participants, respectively. Logistic regression analysis after considering all possible confounding factors represented that an increase in each unit of NO 2 (ppb) exposure was associated with an increased risk of breast density with an OR equal to 1.04 (95CI: 1.01 to 1.07). Furthermore, CO level was associated with a decreasing breast density (OR = 0.40, 95CI = 0.19 to 0.86). None of the other pollutants were associated with breast density. Conclusion: Higher MBD was associated with an increased level of NO 2 , as a marker of traffic-related air pollution. Furthermore, CO concentration was associated with a lower MBD, while other criteria air pollutants were not related to MBD. Further studies are needed to evaluate the association between ambient air pollutants with MBD.

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“…Numerous studies have evaluated the effects of aspirin and metformin on MBD with inconsistent results (33)(34)(35)(36). In addition some researches have shown that higher vitamin D and calcium intake are associated with decreased MBD (37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Air pollution Exposure And Mammographic Breast Density In Tehran, Iran

Eslami

Alipour

Omranipour

et al. 2021

Preprint

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Background: Air pollution is one of the major public health challenges in many parts of the world possibly has an association with breast cancer. However, the mechanism is still unclear. This study aimed to find an association between exposure to six criteria ambient air pollutants (PM2.5, PM10, SO2, NO2, O3, and CO) and mammographic breast density (MBD), as one of the strongest predictors for developing breast cancer, in women living in Tehran, Iran.Methods: Participants were selected from women attending two university hospitals for screening mammography from 2019 to2021. Breast density was rated by two expert radiologists. Individual exposures to 3-years ambient air pollution levels at the residence were estimated.Results: The final analysis in 791 eligible women showed that low and high breast density was detected in 34.8% and 62.2% of participants, respectively. Logistic regression analysis after considering all possible confounding factors represented that an increase in 10 units of NO2 (ppb) exposure was associated with an increased risk of breast density with an OR equal to 1.47 (95% CI: 1.10 to 1.97). Furthermore, CO level was associated with a decreasing breast density (OR = 0.33, 95% CI = 0.17 to 0.64). None of the other pollutants were associated with breast density.Conclusion: MBD was associated with higher levels of ambient air NO2 and lower levels of CO. Perhaps MBD monitoring as an available tool in each population, can help the prediction of future breast cancer occurrence and finding the high-risk geographic areas.

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The Effect of Vitamin D Supplementation on Breast Density Changes: A Clinical Trial Study

Abstract: This study showed that monthly consumption of 50,000 IU of vitamin D supplementation for 1 yr did not affect breast density.

Cited by 7 publications

References 16 publications

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

Air pollution exposure and mammographic breast density in Tehran, Iran: a cross-sectional study

Air pollution Exposure And Mammographic Breast Density In Tehran, Iran

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