The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort

Bae, Jisuk; Shin, Dong Hoon; Chun, Byung-Yeol; Choi, Bo Youl; Kim, Mi Kyung; Shin, Min‐Ho; Lee, Younghoon; Park, Pil Sook; Kim, Seong-Kyu

doi:10.1016/j.jbspin.2014.05.007

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…Covariates were chosen based on some published studies. 28–31 The female subgroup was also adjusted for menopausal status. Tests for linear trends were conducted based on logistic regression, using a median variable of Zn level in each category.…”

Section: Methodsmentioning

confidence: 99%

Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study

et al. 2015

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ObjectiveTo examine the associations between dietary zinc intake and hyperuricaemia.DesignCross-sectional study.SettingThis study was conducted in a health examination centre of China.ParticipantsA total of 5168 middle-aged and older participants (aged 40 years or above) (2697 men and 2471 women) were included.Outcome measuresDietary zinc intake was assessed using a validated semiquantitative food frequency questionnaire. Hyperuricaemia was defined as uric acid ≥416 µmol/L for males and ≥360 µmol/L for females.ResultsFor males, the prevalence of hyperuricaemia was 22.9%. After adjusting for age, body mass index (BMI) and energy intake, the ORs were 0.68 (95% CI 0.45 to 0.92) in the second quintile, 0.63 (95% CI 0.45 to 0.89) in the third quintile, 0.68 (95% CI 0.46 to 1.00) in the fourth quintile and 0.55 (95% CI 0.35 to 0.87) in the fifth quintile comparing the lowest quintile of Zn intake, respectively (p for trend=0.03). In the multivariable adjusted model, the relative odds of hyperuricaemia were significantly decreased by 0.71 times in the second quintile of zinc intake (OR 0.71, 95% CI 0.52 to 0.98), 0.64 times in the third quintile (OR 0.65, 95% CI 0.44 to 0.94) and 0.55 times in the fifth quintile (OR 0.56, 95% CI 0.32 to 0.97) compared with those in the lowest quintile, and p for trend was 0.064. For females, the prevalence of hyperuricaemia was 10.0%, and unadjusted, minimally adjusted as well as multivariable adjusted ORs all suggested no significant association between dietary zinc intake and hyperuricaemia.ConclusionsThe findings of this cross-sectional study indicated that dietary zinc intake was inversely associated with hyperuricaemia in middle-aged and older males, but not in females. The association was significant after considering the influence of age, BMI and energy intake, and after that, minimum adjustment remained independent of further confounding factors such as vitamin C intake, alcohol drinking status and nutrient supplementation.

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Section: Methodsmentioning

confidence: 99%

Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study

et al. 2015

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“…Moreover, our findings strongly agree with Stamp et al [11] who found no significant difference in serum UA levels between gout patients group who did or did not take vitamin C supplementation (500 mg/day) after 8 weeks, despite the increase in plasma ascorbate levels. Likewise, many other meta-analysis of randomized controlled trails and cross sectional studies have reported the urate lowering effects of modest oral dosage of vitamin C supplements in hyperuricemic subjects, as well as the promising role of this viamin in risk reduction of gout [1,6,7,12]. Although, these previuos papers have evaluated the efficacy of oral vitamin C supplementaion on UA level, Biniaz et al [13] found that post-heamodialysis intravenous injection of vitamin C in hyperuricemic chronic kidney disease patients significantly reduces serum UA levels (p < 0.001) in comparison to control groups (p= 0.09 and p= 0.39).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms for the urate lowering effect by vitamin C have been proposed in previous studies. It has been suggested that vitamin C has a biological uricosuric effect that modulates serum concentration of UA, as both reabsorbed via an anion-exchange transport system at proximal tubule [1,6,7,12]. Therefore, high concentration of vitamin C may competitively impede renal reabsorption of UA in the apical brush border of the proximal tubule through cis-inhibtion of either sodium-dependent anion cotransporter (SLC5A8/A12), UA transport molecules (such as URAT1, the main target of uricosurics) or both (ibid).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C is considered one of the protective modifiable factors against hyperuricemia by its uricosuric effect. Recently, findings of a prospective cohort study suggested that vitamin C supplementation has a reduction effect on serum UA concentrations that might be beneficial in the prevention of gout [6]. The results of a meta-analysis of 13 randomized controlled trials support the potential evidence for the inverse association between increased vitamin C intake and the risk of hyperuricemia [7].…”

Section: Introductionmentioning

confidence: 95%

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Vitamin C Supplementation and Hyperuricemia: Fact or Hoax?

Azzeh

et al. 2016

Preprint

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Hyperuricemia is commonly diagnosed in subjects with abnormal purine metabolism. Prolonged hyperuricemia often associated with gout, which is a vital risk factor for joint dysfunction. The current study was designed to determine the efficacy of vitamin C supplements for treatment of high serum uric acid (UA) among hyperuricemic and gouty patients, and finding-out the effect of supplementation on serum creatinine (Cr) level and glomerular filtration rate (GFR). This intervention study was started in April, 2013, till two months. A convenient sample of 30 adults aged between 24-75 years of both genders was assigned into two study groups: hyperuricemic (n=15) and gouty (n=15) groups. Each participant supplemented with 500 mg/day vitamin C chewable tablets for 2 months. Serum UA, Cr, and GFR were measured before and after treatment. At the end of this study, Cr and GFR enhanced insignificantly in both groups. UA increased insignificantly in gouty group after 2 months by about 0.31 mg/dl. On the other hand, hyperuricemic group showed significant (P ≤0.05) decrease in UA (-0.78 mg/dl) after 2 months duration. In conclusion, supplementation with 500 mg/day vitamin C for 2 months significantly attenuated serum UA for hyperuricemic patients and insignificantly affected serum UA in gouty patients. The uselessness of vitamin C supplements on gouty patients could be associated to a number of possible reasons.

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“…37 A Korean Multi-Rural Communities Cohort study showed that higher levels of dietary vitamin C intake, but not total vitamin C intake, are associated with a lower risk of hyperuricemia in both men and women. 38 Firas et al, supplementation with 500 mg/day chewable vitamin C for 2 months significantly attenuated serum uric acid for hyperuricemic patients and insignificantly affected serum uric acid in gouty patients. The uselessness of vitamin C supplements on gouty patients could be associated to number of possible reasons.…”

Section: Andmentioning

confidence: 98%

Is vitamin C able to reduce hyperuricemia

Hantono¹

2019

Int J Res Med Sci

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Hyperuricemia is defined as high levels of blood uric acid, the product of purine metabolism, which can form uric acid crystals and lead to become gout. Gout is a systemic disease that results from chronic elevation of uric acid levels above the threshold point and form the deposition of monosodium urate (MSU) crystals in tissues, mainly in and around the joints forming tophi. The impact of gout and its associated conditions can cause deformity, morbidity and mortality. Vitamin C is shown to has beneficial effect in lowering serum uric acid level in hyperuricemia patients with unknown mechanism. But it is still debatable whether using or not using and the dose of vitamin C because giving large doses also had no effect on serum uric acid concentration, uric acid excretion and clearance by the kidney, and even can cause adverse effects.

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The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort

Cited by 18 publications

References 25 publications

Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study

Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study

Vitamin C Supplementation and Hyperuricemia: Fact or Hoax?

Is vitamin C able to reduce hyperuricemia

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