The effect of vitamin C on mucopoly‐saccharide production in wound healing

Penney, Jenna; Balfour, Brigid M.

doi:10.1002/path.1700610204

Cited by 93 publications

(14 citation statements)

References 11 publications

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“…GERSH and CATCH-POLE [2] feel that depolymerization of glycoprotein of the basement membrane of blood vessels may result in weakening of the wall with consequent proneness to haemorrhage. PENNEY and BALFOUR [6] think the haemorrhages associated with scurvy might be due to failure in mucopolysaccharide formation in connective tissue elements of the blood vessel wall.…”

Section: Resultsmentioning

confidence: 97%

Ascorbic acid studies in spontaneous subarachnoid and intracerebral haemorrhage: Preliminary investigations

Rl¹

1964

Minim Invasive Neurosurg

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The etiology of spontaneous intracranial haemorrhages whether due to aneurysms, vascular malformations or other causes remains obscure. In some patients hypertension seems to play a role, but numerous haemorrhages also occur in normotensive individuals. It would seem reasonable to suspect that some factors weakening blood vessels might be involved. Little study has been made of possible causes of vascular fragility other than atherosclerosis. In this investigation an attempt has been made to evaluate the possible role of avitaminosis C in patients with such haemorrhages. MethodsBlood samples were taken as soon as possible after admission to the hospital from patients with spontaneous intracranial haemorrhages due to aneurysms, arteriovenous malformations, tumours or unknown causes. Patients whose haemorrhages occurred more than one week previously, those on anticoagulant therapy and individuals with blood pressure exceeding 150/100 mm. Hg were not included. Serum ascorbic acid levels were determined according to the method of ROE and KUETHER [7]. In many of these patients an estimation of tissue ascorbic acid saturation was made by the method of CANTAROW and TRUMPETER [1]. Five hour urinary excretion of ascorbic acid was determined after 1 gm. of the substance was administered intravenously. Results and DiscussionAccording to CANTAROW and TRUMPETER [1] the normal plasma ascorbic acid content is between 0.6 and 1.5 mg.%, and this level is maintained by a daily dietary intake of 75 to 100 mg. Laboratory evaluation of the scorbutic state is more accurately assessed by tissue

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Section: Resultsmentioning

confidence: 97%

Ascorbic acid studies in spontaneous subarachnoid and intracerebral haemorrhage: Preliminary investigations

Rl¹

1964

Minim Invasive Neurosurg

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“…Alkaline phosphatase found in mast cells may be concerned with the extrusion of the metachromatic substance of mast-cell granules (156), which are rapidly ejected from the cells following the stimulus of a bacterial pyrogen given intravenously (183). Secretion of ground sub stance is probably mediated by vitamin C since in s curvy very little meta chromatic material is present in regenerating connective tissue (141). Mast cells have been said to secrete synovial fluid hyaluronic acid (6), and synovial cells grown in tissue culture have produced a "mucin" (194).…”

Section: Ground Substancementioning

confidence: 99%

“…On low doses of ascorbic acid (less than 2 mg. daily), large amounts of reticulum are formed in a wound (33), although the wounds are abnormal in appearance. No metachromatic material is formed during repair in scurvy· (141), but with low doses of ascorbic acid, large amounts are laid down. In scurvy, no meta chromatic material is seen in regenerating cartilage and it has been suggested that the connective tissue fault in scurvy is due to the inability of the tissues to form chondroitin sulfuric acid (120).…”

Section: Scurvymentioning

confidence: 99%

The Physiology of the Connective Tissue (Loose Areolar)

Ragan¹

1952

Annu. Rev. Physiol.

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“…The fundamental importance of vitamin C in the healing process has been demonstrated in guinea-pigs (Bourne, 1944;Penney and Balfour, 1949;Gould, 1958;Ellis, Harrison, and Hugh, 1965) and in humans (Hunt, 1941;Boyd and Campbell, 1950), the two animal species known not to synthesize ascorbic acid. It is therefore important to understand the significance of the low blood levels of ascorbic acid consistently found in patients with peptic ulcer (Harris, Abbasy, Yudkin, and Kelly, 1936;Platt, 1936;Archer and Graham, 1936;Lazarus, 1937;Portnoy and Wilkinson, 1938), as in these patients surgery is often the treatment of choice.…”

mentioning

confidence: 99%