The Effect of Viagra on Autonomic Function Using Spectral Analysis and Approximate Entropy Method

Kamal, Ahmed

doi:10.4172/2376-0281.1000156

Cited by 3 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This feature is postulated to the reduction of vagal modulation and side by side higher sympathetic activity. The findings of the present study confirm the sympathovagal imbalance which was also observed by other researchers 2,6,[8][9][10] . Determination of PNN50% demonstrates parasympathetic activity at cardiac level.…”

Section: Discussionsupporting

confidence: 82%

“…In this study HRV parameters in the healthy control group were within normal range and also similar to that of other reports from abroad 2,6,8,9 and at home 16,17,18 .…”

Section: Discussionsupporting

confidence: 77%

“…Again, lower values of SDNN, RMSSD and PNN50% were reported by various investigators of different countries in patients with rheumatoid arthritis in comparison with those of healthy control 6,8,9 .…”

mentioning

confidence: 99%

“…Lower values of mean R-R interval and higher values of mean heart rate were mentioned by some investigators in patients with rheumatoid arthritis when compared with those of healthy control 2,6,[8][9][10] .…”

mentioning

confidence: 99%

“…Involvement of cardiac tissue in RA suggested to encompass both autonomic components and result in sympathovagal imbalance 2,5,6 .…”

mentioning

confidence: 99%

See 4 more Smart Citations

Heart Rate Variability in Patients with Rheumatoid Arthritis

Jahan

Begum

Ferdousi

2013

J Bangladesh Soc Physiol

View full text Add to dashboard Cite

Background: Altered cardiovascular autonomic nerve function with impaired sympathovagal balance is found in rheumatoid arthritis (RA). Heart Rate Variability (HRV) analysis is an important tool for assessment of autonomic nerve activity. Objective: To assess cardiac autonomic nerve function status in patients with Rheumatoid arthritis (RA) by time domain measures of HRV. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January to December 2010. Sixty female RA patients, age range 18-50 years were constituted study group enrolled from the Out-patient Rheumatology Wing, Department of Medicine, BSMMU. Age matched thirty apparently healthy females were studied as control. Time domain measures of Heart Rate Variability (HRV) such as Mean RR intervals, Mean HR, SDNN, RMSSD, NN50% and PNN 50% were recorded for 5 minutes by a Polygraph machine to observe cardiac autonomic nerve function activity. Data were analyzed by independent sample t test. Results: Mean R-R interval, SDNN, RMSSD, PNN50%, NN50% were significantly lower (p<0.001) but heart rate was significantly (P<0.001) higher in rheumatoid arthritis patients. Conclusion: Cardiac autonomic nerve function is impaired and characterized by reduced resting parasympathetic activity in female Rheumatoid Arthritis patients.

show abstract

Section: Discussionsupporting

confidence: 82%

“…In this study HRV parameters in the healthy control group were within normal range and also similar to that of other reports from abroad 2,6,8,9 and at home 16,17,18 .…”

Section: Discussionsupporting

confidence: 77%

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Involvement of cardiac tissue in RA suggested to encompass both autonomic components and result in sympathovagal imbalance 2,5,6 .…”

mentioning

confidence: 99%

See 3 more Smart Citations

Heart Rate Variability in Patients with Rheumatoid Arthritis

Jahan

Begum

Ferdousi

2013

J Bangladesh Soc Physiol

View full text Add to dashboard Cite

show abstract

Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis

Lazzerini¹,

Capecchi²,

2016

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic immuno-mediated disease primarily affecting the joints, characterized by persistent high-grade systemic inflammation. Cardiovascular morbidity and mortality are significantly increased in RA, with >50% of premature deaths attributable to cardiovascular disease. In particular, RA patients were twice as likely to experience sudden cardiac death compared with non-RA subjects, pointing to an increased propensity to develop malignant ventricular arrhythmias. Indeed, ventricular repolarization (QT interval) abnormalities and cardiovascular autonomic nervous system dysfunction, representing two well-recognized risk factors for life-threatening ventricular arrhythmias in the general population, are commonly observed in RA. Moreover, large population-based studies seem to indicate that also the prevalence of atrial fibrillation is significantly higher in RA subjects than in the general population, thus suggesting that these patients are characterized by an abnormal diffuse myocardial electrical instability. Although the underlying mechanisms accounting for the pro-arrhythmogenic substrate in RA are probably intricate, the leading role seems to be played by chronic systemic inflammatory activation, able to promote arrhythmias both indirectly, by accelerating the development of ischaemic heart disease and congestive heart failure, and directly, by affecting cardiac electrophysiology. In this integrated mechanistic view, lowering the inflammatory burden through an increasingly tight control of disease activity may represent the most effective intervention to reduce arrhythmic risk in these patients. Intriguingly, these considerations could be more generally applicable to all the diseases characterized by chronic systemic inflammation, and could help elucidate the link between low-grade chronic inflammation and arrhythmic risk in the general population.

show abstract

Parasympathetic Nerve Function Status in Female with Rheumatoid Arthritis

Jahan¹,

Begum

Ferdousi

2013

J Bangladesh Soc Physiol

View full text Add to dashboard Cite

Background: Sudden cardiac death in patients with Rheumatoid Arthritis has been attributed to the decreased vagal drive to the heart. Objective: To assess cardiac parasympathetic nerve function status in patients with Rheumatoid Arthritis (RA). Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from January to December 2010. Sixty female RA patients aged 18-50 years were included in the study group. They were enrolled from the Out Patient Department of Rheumatology Wing of the Department of Medicine, BSMMU, Dhaka. For comparison age matched thirty apparently healthy females were also studied as control. To assess parasympathetic nerve function status, all the subjects were examined by three noninvasive cardiovascular reflex tests such as heart rate response to valsalva maneuver (valsalva ratio), heart rate response to deep breathing and heart rate response to standing (30 th :15 th ratio). For statistical analysis independent sample t test was used. Results: Mean values of valsalva ratio, deep breathing test and 30 th :15 th ratio were significantly (p<0.001) lower in rheumatoid arthritis patients compared to those of healthy control. Conclusion: From this study it may be concluded that lower cardiac parasympathetic nerve activity characterized the autonomic nerve dysfunction in patients with Rheumatoid Arthritis.

show abstract

The Effect of Viagra on Autonomic Function Using Spectral Analysis and Approximate Entropy Method

Cited by 3 publications

References 7 publications

Heart Rate Variability in Patients with Rheumatoid Arthritis

Heart Rate Variability in Patients with Rheumatoid Arthritis

Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis

Parasympathetic Nerve Function Status in Female with Rheumatoid Arthritis

Contact Info

Product

Resources

About