The Effect of Veiled Cells on Lymphocyte Function

Immune modulation with dendritic cells

“…Phenotypically, myeloid DCs are large, mononuclear cells, often with a monocyte‐like appearance in the immature stage that, when mature, acquire a veiled appearance due to their characteristic membranous extensions that are used to interact intimately with T cells during antigen presentation (Balfour et al ., 1982; Knight, 1984; Knight et al ., 1986; Reid et al ., 1990). Immature myeloid DCs are specialized in their ability to take up and process antigen for presentation on MHC class I and II receptors (Banchereau et al ., 2000; Ridge et al ., 1998; Grakoui et al ., 1999).…”

“…Myeloid DCs originate in the bone marrow, traverse through the peripheral blood and settle in the tissue for varying lengths of time before travelling via the afferent lymph to the lymph node where the majority of antigen presentation occurs (Balfour et al ., 1982; Knight, 1984; Banchereau et al ., 2000). Plasmacytoid DCs also have their origins in the CD34 + stem/precursor cell of the bone marrow before they traverse through the blood and settle in the tissues near the venous channels (Bianca et al ., 2002; Briere et al ., 2002).…”