The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds

Zhang, F; Lei, Man-Ping; Oswald, Tanya; Pang, Yi; Blain, Brantley; Cai, Zhengwei; Lineaweaver, William C.

doi:10.1016/s0007-1226(03)00175-9

Cited by 64 publications

(42 citation statements)

References 30 publications

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“…Generally, wound healing consists of three steps: (1) the inflammatory step, which consists of inflammatory cell migration; (2) the proliferative step, which consists of new tissue formations such as angiogenesis, fibroplasia, matrix accumulation, and epithelialization; and (3) the tissue remodeling step, which consists of the angiogenic activation of endothelial cells. The activation plays an important role in inflammation, matrix synthesis, fibroblast proliferation, and epithelialization in wound healing [23]. In the present study, with long-term HBO treating on post-laminectomy rats, the level of the fibrosis and the number of fibroblast were inhibited.…”

Section: Discussionmentioning

confidence: 42%

An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1

Zhao

et al. 2014

Eur J Orthop Surg Traumatol

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Section: Discussionmentioning

confidence: 42%

An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1

Zhao

et al. 2014

Eur J Orthop Surg Traumatol

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“…In wound healing, however, angiogenesis is a necessary phase. Exogenous application of VEGF increases early angiogenesis and tensile strength even in the ischemic wounds 23 .…”

Section: Discussionmentioning

confidence: 99%

The effect of prophylactic dose of a low molecular weight heparin on skin wound healing of rats

et al. 2009

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Purpose:To investigate the effect of prophylactic dose of a low molecular weight heparin, enoxaparin, on skin wound healing of rats. Methods: Forty rats were used for the study. Rats were randomly assigned to two equal groups. Experimental group received prophylactic dose of enoxaparin. Physiologic saline was administered to the control group. Parameters of wound healing of experimental and control groups were compared. For comparison of the groups in terms of fibrosis, vascularization, inflammation, epithelization, and tensile strength test (Newton). Mann-Whitney-U test was used because variables were categorical data (fibrosis, vascularization, inflammation and epithelization). Differences between groups were analyzed with independent samples t-test (tensile strength). Significance was set at p<0.05. Results: Skin wound of the experimental group presented tensile strength significantly decreased (p<0.001), histopathologic examination revealed a significant (p<0.001) delayed epithelization and decreased in fibrosis, vascularization, inflammation (p<0.001) in the experimental group. Conclusion: Enoxaparin delay wound healing by decreased inflammatory cells, fibroblast contents and their products (growth factors), and by promoted hemorrhage.

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“…5), confirming a property already described in literature. 6,13,14,22,39,40 Immunostaining the same samples with an antibody specific for a-Smooth Muscle Actin, emphasized the neoangiogenetic process taking place in AAV-VEGF-treated tissues, by demonstrating the massive presence of arterial vessels (Fig. 6), particularly in samples from group 9 (vector inoculation 14 days before surgery).…”

Section: Resultsmentioning

confidence: 95%

Improved survival of rat ischemic cutaneous and musculocutaneous flaps after VEGF gene transfer

et al. 2007

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When harvesting microsurgical flaps, the main goals are to obtain as much tissue as possible based on a single vascular pedicle and a reliable vascularization of the entire flap. These aims being in contrast to each other, microsurgeons have been looking for an effective way to enhance skin and muscle perfusion in order to avoid partial flap loss in reconstructive surgery. In this study we demonstrate the efficacy of VEGF 165 delivered by an Adeno-Associated Virus (AAV) vector in two widely recognized rat flap models. In the rectus abdominis myocutaneous flap, intramuscular injection of AAV-VEGF reduced flap necrosis by 50%, while cutaneous delivery of the same amount of vector put down the epigastric flap's ischemia by >40%. Histological evidence of neoangiogenesis (enhanced presence of CD31-positive capillaries and alpha-Smooth Muscle Actin-positive arteriolae) confirmed the therapeutic effect of AAV-VEGF on flap perfusion.

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The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds

Cited by 64 publications

References 30 publications

An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1

An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1

The effect of prophylactic dose of a low molecular weight heparin on skin wound healing of rats

Improved survival of rat ischemic cutaneous and musculocutaneous flaps after VEGF gene transfer

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