The Effect of Varying Temperatures on the Post-Transfusion Survival of Whole Blood During Depot Storage and After Transportation by Land and Air 1

Gibson, John G.; Sack, Theodore; Evans, Robley D.; Peacock, Wendell C.

doi:10.1172/jci101857

Cited by 31 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the past 50 years, few of the seminal studies advancing RBC storage practices have addressed how modern practices affect the optimal storage temperature. [15][16][17][18][19][20][21][22][23][24] Storage temperature was examined in the late 1970s 25 during the development of modern preservative solutions. Similar to our findings, these studies showed that raising storage temperature from 2.5 to 5.5 C with modern storage solutions over 6 weeks increased lactate production and lowered pH.…”

Section: Discussionmentioning

confidence: 99%

Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival

et al. 2018

View full text Add to dashboard Cite

BACKGROUND Storage temperature is a critical factor for maintaining red-blood cell (RBC) viability, especially during prolonged cold storage. The target range of 1 to 6°C was established decades ago and may no longer be optimal for current blood-banking practices. STUDY DESIGN AND METHODS Human and canine RBCs were collected under standard conditions and stored in precision-controlled refrigerators at 2°C, 4°C, or 6°C. RESULTS During 42-day storage, human and canine RBCs showed progressive increases in supernatant non-transferrin-bound iron, cell-free hemoglobin, base deficit, and lactate levels that were overall greater at 6°C and 4°C than at 2°C. Animals transfused with 7-day-old RBCs had similar plasma cell-free hemoglobin and non-transferrin-bound iron levels at 1 to 72 hours for all three temperature conditions by chromium-51 recovery analysis. However, animals transfused with 35-day-old RBCs stored at higher temperatures developed plasma elevations in non–transferrin-bound iron and cell-free hemoglobin at 24 and 72 hours. Despite apparent impaired 35-day storage at 4°C and 6°C compared to 2°C, posttransfusion chromium-51 recovery at 24 hours was superior at higher temperatures. This finding was confounded by a preparation artifact related to an interaction between temperature and storage duration that leads to removal of fragile cells with repeated washing of the radiolabeled RBC test sample and renders the test sample unrepresentative of the stored unit. CONCLUSIONS RBCs stored at the lower bounds of the temperature range are less metabolically active and produce less anaerobic acidosis and hemolysis, leading to a more suitable transfusion product. The higher refrigeration temperatures are not optimal during extended RBC storage and may confound chromium viability studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Maintenance of any given temperature within an insulated box is dependent upon three variables [1] the temperature of the box at the commencement of the test, [2] the adequacy of the insulation of the box, and [3], the length of exposure to an extreme temperature.…”

Section: Methodsmentioning

confidence: 99%

“…It is most important that the temperature of such blood should not be allowed to reach freezing point (-0.57 to -0.62°C) or to rise above 8-10°C for any period exceeding half an hour [7]. Exposure of blood to temperatures in excess of those sti pulated may not only allow the multiplication of any chance con taminating bacteria present, but will also lead to a diminished rate of post transfusion survival [3,8]. On the other hand, transfusion of free haemoglobin (as would occur if blood were used after having been frozen) may lead to a severe, perhaps fatal reaction [2].…”

mentioning

confidence: 99%

A Comparative Survey of the Insulating Properties of Four Common Blood Transport Containers

Farr¹

1962

Vox Sanguinis

View full text Add to dashboard Cite

“…Unfortunately, the average distance between collection points and laboratories is increasing, together with the risk of deterioration of the samples during transport time (Gibson et al 1947;Or and Pierskalla 1979;Fakhr et al 2012). A similar issue affects blood banks, which are becoming more and more centralized in order to be able to serve larger areas.…”

Section: Introductionmentioning

confidence: 99%

Simulation Model of the Control System of Portable Boxes for Blood Bags Transport

2019

Modeling and Simulation in Medicine (MSM 2019)

View full text Add to dashboard Cite

Blood transport is very important in the healthcare sector; new technologies can help implement efficient transport systems. To maintain unaltered the bio-chemical properties of blood during transports, blood bags need to be kept within a precise temperature range for the entire travel time.This paper presents a Matlab-Simulink model of an innovative box for blood transport, including a temperature control system which employs eutectic fluid elements exchanging heat with the transported blood bags. To keep the temperature within the correct range, on-off blowers provide an air flow between the eutectic and blood compartments.The basic idea is to equip the boxes with sensors that dialogue by cloud with a server on which the simulator is installed; this allows to continuously monitor the time remaining before the exhaustion of the eutectic cooling effect, in which case a logistic algorithm will provide the coordinates of the nearest healthcare location for blood deposition.

show abstract

The Effect of Varying Temperatures on the Post-Transfusion Survival of Whole Blood During Depot Storage and After Transportation by Land and Air 1

Cited by 31 publications

References 4 publications

Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival

Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival

A Comparative Survey of the Insulating Properties of Four Common Blood Transport Containers

Simulation Model of the Control System of Portable Boxes for Blood Bags Transport

Contact Info

Product

Resources

About