“…For low σ HAP values (σ HAP ≪ B ), and for relatively high σ HAP values, The experimental data in the present work were fitted according to eq 4 as shown in Figure and the values obtained were 8.43 × 10 -9 and 1.39 × 10 -9 mol min -1 m -2 in the presence of Mdm 2 peptide in the supersaturated solutions, respectively. The second-order dependence for the seeded crystal growth of HAP on HAP seed crystals has been found in the past in the literature. − 4 Kinetics of HAP crystal growth in the presence of various concentrations of Mdm2, according to the kinetic model based on a Langmuir-type adsorption (pH 7.40, 37 °C, 0.15 M NaCl, 5 × 10 -4 mol dm -3 total calcium).…”
Section: Resultsmentioning
confidence: 91%
“…The second-order dependence for the seeded crystal growth of HAP on HAP seed crystals has been found in the past in the literature. [27][28][29][30] Furthermore, upon increasing the solution concentration of the Mdm2 peptide further HAP crystallization inhibition was observed (Table 1). Potentiometric titrations of the Mdm2 at the same experimental conditions employed in the kinetic studies (i.e., pH ) 7.4, 0.15 M NaCl, 37 °C) in the presence and in the absence of total calcium 5 × 10 -4 M did not show any appreciable complexation.…”
The crystal growth of hydroxyapatite (HAP), the most stable calcium phosphate phase at 37 °C, pH 7.40, and ionic strength of 0.15 M NaCl, in the presence of the cysteine-rich Mdm2 peptide (containing 48 aminoacids in ring finger configuration) has been investigated by the constant composition technique. Crystallization took place exclusively on well-characterized HAP crystals in supersaturated solutions only with respect to this calcium phosphate salt. The kinetic results indicated a surface diffusion spiral growth mechanism. The presence of the Mdm2 peptide inhibited the crystal growth of HAP by 59-92% through adsorption onto the active growth sites of the HAP crystal surface. The kinetic results favored a Langmuir-type adsorption model, and the value of the calculated affinity constant was k aff ) (258 ( 21) × 10 4 dm 3 mol -1 .
“…For low σ HAP values (σ HAP ≪ B ), and for relatively high σ HAP values, The experimental data in the present work were fitted according to eq 4 as shown in Figure and the values obtained were 8.43 × 10 -9 and 1.39 × 10 -9 mol min -1 m -2 in the presence of Mdm 2 peptide in the supersaturated solutions, respectively. The second-order dependence for the seeded crystal growth of HAP on HAP seed crystals has been found in the past in the literature. − 4 Kinetics of HAP crystal growth in the presence of various concentrations of Mdm2, according to the kinetic model based on a Langmuir-type adsorption (pH 7.40, 37 °C, 0.15 M NaCl, 5 × 10 -4 mol dm -3 total calcium).…”
Section: Resultsmentioning
confidence: 91%
“…The second-order dependence for the seeded crystal growth of HAP on HAP seed crystals has been found in the past in the literature. [27][28][29][30] Furthermore, upon increasing the solution concentration of the Mdm2 peptide further HAP crystallization inhibition was observed (Table 1). Potentiometric titrations of the Mdm2 at the same experimental conditions employed in the kinetic studies (i.e., pH ) 7.4, 0.15 M NaCl, 37 °C) in the presence and in the absence of total calcium 5 × 10 -4 M did not show any appreciable complexation.…”
The crystal growth of hydroxyapatite (HAP), the most stable calcium phosphate phase at 37 °C, pH 7.40, and ionic strength of 0.15 M NaCl, in the presence of the cysteine-rich Mdm2 peptide (containing 48 aminoacids in ring finger configuration) has been investigated by the constant composition technique. Crystallization took place exclusively on well-characterized HAP crystals in supersaturated solutions only with respect to this calcium phosphate salt. The kinetic results indicated a surface diffusion spiral growth mechanism. The presence of the Mdm2 peptide inhibited the crystal growth of HAP by 59-92% through adsorption onto the active growth sites of the HAP crystal surface. The kinetic results favored a Langmuir-type adsorption model, and the value of the calculated affinity constant was k aff ) (258 ( 21) × 10 4 dm 3 mol -1 .
“…116 The chemical precipitation process relies on providing an ambient temperature as well as pH, in which HAp exhibits minimum solubility and a maximal CaP stable phase in liquid solution. 8,[121][122][123][124][125][126] However, the precipitation reaction normally occurs at a higher pH (44.2) along with temperatures ranging from 40 to 100 1C, 8,116,[127][128][129][130][131][132][133][134][135][136][137] but synthesis occurs at a low temperature can minimize the crystallinity of HAp particles. 116 In HAp synthesis, the most challenging step is the exquisite control of crystal growth because it directly relies on the geometrical shape as well as the size of the final products.…”
Calcium hydroxyapatite commonly expressed in a single word, hydroxyapatite (HAp) represents a mineral manifestation of calcium apatite and is denoted via the molecular formula Ca5(PO4)3(OH). Since its close molecular resemblance...
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