The Effect of Vagal Block or Hexamethonium on Gastric Secretion in the Dog

Abstract

LIMBOSCH, J.-M., WYLLIE, J. H. & NYHUS, LLOYD M. The Effect of Vagal Block or Hexamethonium on Gastric Secretion in the Dog. Scand. J . Gasfroent. 3,7-17, 1968.Because of relevance to the operation of vagotomy in man, and to 'medical vagotomy' tests attempting to forecast the results of surgery, we have made a study in the dog of the effects of (1) blocking the vagus nerves with local anaesthetic and (2) injecting intravenously a ganglion-blocking drug. Gastric secretion was stimulated with both high and low doses of histamine and gastrin in dogs equipped with either a Heidenhain or a Pavlov pouch. Although the blocking procedures abolished acid and pepsin secretion caused by a pure vagal stimulant (2-deoxy-D-glucose) they had less effect against gastrin, and still less against histamine. The implications of these results are discussed. . (1966) Medical vagotomy; an assessment. Brit. med. J. 11, KOMAROV, S. A. (1942) Studies on gastrin: Physiological properties of the specific gastric secretagogue of the pyloric mucous membrane. Rev. Canad. Eiol. 1, 595-598. 463-471.Scand J Gastroenterol Downloaded from informahealthcare.com by University of Sydney on 01/03/15For personal use only.

Physiology of the Secretion of Acid, Pepsin, Sulfated Polysaccharides and Glycoproteins by the Dog Fundic Mucosa

“…In our experiments using doses th at produced a near maximal acid output a small increase of both pepsin and chondroitin sulfate output was observed. Several experiments have shown th a t exogenous gastrin stim ulates the peptic cells [1][2][3][4][5][6][7][8][9][10][11][12]. The present results show th a t a gastrin-like pentapeptide adm inistered at a dose th a t produces a m aximal acid output increases the pepsin output but changes the chondroitin sulfate output only unsignificantly.…”

“…These cells are poorly affected by histamine [1][2][3][4][5][6][7][8][9][10][11][12]. In our experiments using doses th at produced a near maximal acid output a small increase of both pepsin and chondroitin sulfate output was observed.…”