The Effect of Vacuum Assisted Closure Dressing Technique versus Conventional Dressing on Diabetic Foot Wound Healing

Elshenawie, Hend A. E.; Weheida, Soheir Mohamed; Said, Aziza El

doi:10.21608/asalexu.2016.208672

Cited by 1 publication

(2 citation statements)

References 15 publications

(15 reference statements)

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“…Dermaheal ointment is formulated based on a combination of natural and herbal products such as A. euchroma , Thymus vulgaris , M. chamomilla , C. longa , wax, honey, and olive oil, all of which have anti‐inflammatory, antioxidant, and antimicrobial properties. Therefore, the effectiveness of the ingredients used in this ointment is well‐supported 16,39,40 . For instance, one recent study examined the topical effects of olive oil and honey to improve DFUs in 45 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the effectiveness of the ingredients used in this ointment is well-supported. 16,39,40 For instance, one recent study examined the topical effects of olive oil and honey to improve DFUs in 45 patients. The group receiving honey and olive oil showed significant improvement in the average tissue score around the wound, the degree of the wound, and the wound healing compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Short‐term effect of dressing with Dermaheal ointment in the treatment of diabetic foot ulcer: A double‐blinded randomized controlled clinical trial

Salahi,

Nasiri,

Yazdanpanah

et al. 2024

Health Science Reports

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Background and AimsDiabetic foot ulcers, a major cause of amputations in diabetics, could benefit from natural products as adjuncts to standard care, given the costs and adverse effects of typical therapies. This study aims to evaluate the short‐term effects of dressing with Dermaheal ointment in the treatment of DFUs through a double‐blinded randomized controlled clinical trial.MethodsThis double‐blinded, placebo‐controlled trial included 50 patients with Wagner's ulcer grade I or II, randomly assigned to Dermaheal and placebo groups (received standard treatment and placebo ointment). The ulcer site was dressed daily for four consecutive weeks with either Dermaheal or placebo ointment. Ulcer healing score (using DFU healing checklist), ulcer size with transparent ruler and largest dimension of ulcer, and pain severity using numerical pain rating score (were recorded at five‐time points, including baseline, and on weeks 1, 2, 3, and 4). Also, ulcer healing status was investigated at the trial ended in November 2021.ResultsBoth groups showed significant improvement in ulcer healing over 4 weeks (ptime < 0.001), with more remarkable progress in the Dermaheal group (pgroup = 0.03). At the trial end, complete ulcer healing was also significantly higher in the Dermaheal group compared to the placebo group (56% vs. 12%, p = 0.002). Both groups exhibited a decrease in ulcer size (ptime < 0.001). Considering the baseline ulcer size as a covariate, substantial changes in mean ulcer size were noted in the initial (p = 0.01), second (p = 0.001), third (p = 0.002), and fourth (p = 0.002) weeks of the intervention, showing a preference for the Dermaheal group. However, no significant between‐group difference was observed in pain severity levels.ConclusionDressing with Dermaheal as a topical treatment shows promise in improving healing and reducing the size of diabetic foot ulcers. Further research is needed to confirm these findings' long‐term efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%