The effect of vaccination on the prevalence of paratuberculosis in large dairy herds

Körmendy, B

doi:10.1016/0378-1135(94)90141-4

Cited by 62 publications

(43 citation statements)

References 3 publications

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“…Inactivated vaccines for paratuberculosis are not completely effective in preventing the disease, but they decrease environmental elimination of the bacteria and prevent symptoms of the disease [21,24]. Our results may explain some effect of antibodies generated by vaccination due to the biological properties of the IgG1 involved in the immune response.…”

Section: Discussionmentioning

confidence: 76%

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Bovine IgG1 antibodies againstMycobacterium aviumsubsp.paratuberculosisprotein p34-cx improve association of bacteria and macrophages

et al. 2007

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-Paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (Map), is a chronic granulomatous enteric disease in cattle. Among molecular components of Map, protein p34 was identified as specific and immunodominant for bovine B cells. In order to determine if specific antibodies could influence the course of Map pathogenesis, the interaction between bacteria and bovine macrophages was studied. Bovine polyclonal antibodies from 3 calves vaccinated with protein p34-cx, 6 calves vaccinated with heatkilled Map, 8 naturally infected, and 3 healthy calves -as negative controls-were used. Specific anti-Map, -p34-cx and -PPA-3 antibodies were evaluated and isotype characterized. Infected and Map vaccinated animals showed similar IgG1 and IgG2 response against Map whole bacteria. When p34-cx was used as the antigen, mainly IgG1 and IgG3 were detected in infected and only IgG1 in p34-cx vaccinated animals. Bovine polyclonal antibodies from three animals of each category were isolated and affinity purified through Map and p34-cx columns. The effect of these antibodies in association with Map and a transformed bovine peritoneal macrophage's cell line (Bov-Mac) as well as activation of NF-κB transcription factor was studied. Our results show that association of Map significantly increased in vitro after pretreatment with bovine anti-Map or anti-p34-cx antibodies obtained from vaccinated or infected cattle when compared with those of controls. Improved activation of NF-κB was detected in macrophages that ingested Map opsonized with either anti-Map or anti-p34-cx specific antibodies of infected or vaccinated calves, suggesting that both anti-Map and IgG1 anti-p34-cx antibodies support Map-macrophage interactions.Mycobacterium avium subsp. paratuberculosis / p34 / IgG1 / macrophages / cattle

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Section: Discussionmentioning

confidence: 76%

“…Whole bacteria inactivated vaccine was formulated with Map heat inactivated emulsified in oil incomplete Freund adjuvant (Sigma Chemical Co., St. Louis, MO, USA). Each dose contained approximately 20 mg of dry microorganisms [24]. No adverse reactions were detected in this group.…”

Section: Animalsmentioning

confidence: 89%

Bovine IgG1 antibodies againstMycobacterium aviumsubsp.paratuberculosisprotein p34-cx improve association of bacteria and macrophages

et al. 2007

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“…If possible, vaccination should be used with other management procedures to reduce the exposure of susceptible animals (Kennedy and Benedictus, 2001). Nevertheless, vaccinated animals continue to shed mycobacteria, react to serological tests for paratuberculosis (Spangler et al, 1991;Körmendy, 1994). Because these animals respond to the tuberculin used to perform intradermal test against M. bovis, permanent identification of these animals will be necessary.…”

Section: Vaccinationmentioning

confidence: 99%

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

Ayele¹,

Macháčková²,

Pavlík³

2001

Vet. Med.

108

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Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) infects domestic cattle, sheep, goats, deer, camelids and wild ruminants leading to chronic enteritis known as paratuberculosis (Johne’s disease). The infection is chronic, progressive and unresponsive to treatment. Most infected animals do not develop clinical disease but may excrete the bacteria. Clinically sick animals suffer emaciation and in some species diarrhoea, followed by eventual death. During the course of the disease, excretion of M. paratuberculosis in faeces and milk occurs, and the organism spreads through the blood and lymph vessels of infected animals to multiple internal organs. The infection disseminates to both the female and male reproductive organs. Though M. paratuberculosis is not classified as a human pathogen, current opinions on the possible role of this mycobacteria in public health is discussed. This article attempts to review the ways and circumstances by which M. paratuberculosis is transmitted within an animal population and the importance of the disease on animal production. Published reports concerning the transmission and epidemiology of the disease are reviewed herein, and preventive and control measures are summarised.

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“…The use of Dietzia has also been suggested for individuals with inflammatory bowel disease (Click, 2011). Vaccines are effective in reducing the incidence of clinical Johne's disease (Kormendy, 1994;van Schaik et al, 1996) and attenuate pre-existing infection (Gwozdz et al, 2000). However, such whole killed vaccines do not eliminate subclinical MAP infection or its persistence in the gut.…”

Section: Map -The Futurementioning

confidence: 99%

Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

Dow¹,

Sechi²

2011

Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy

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The effect of vaccination on the prevalence of paratuberculosis in large dairy herds

Cited by 62 publications

References 3 publications

Bovine IgG1 antibodies againstMycobacterium aviumsubsp.paratuberculosisprotein p34-cx improve association of bacteria and macrophages

Bovine IgG1 antibodies againstMycobacterium aviumsubsp.paratuberculosisprotein p34-cx improve association of bacteria and macrophages

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

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