The effect of unsaturated fatty acids in benzyl alcohol on the percutaneous permeation of three model penetrants

Nanayakkara, Gihan R.; Bartlett, A.; Forbes, Ben; Marriott, Chris; Whitfield, P. J.; Brown, Marc

doi:10.1016/j.ijpharm.2005.05.024

Cited by 46 publications

(31 citation statements)

References 36 publications

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“…As expected, an increase in the ester chain length of parabens decreased the permeation flux but increased permeability coefficient. The results were similar to those conducted by using whole shed skin of Elaphe obsoleta [3,18] and comparable to the results obtained by using the human skin [19,20] . Comparison of permeation profiles of methyl salicylate, salicylic acid and sodium salicylate through SSS and HE, were shown in Fig.…”

Section: Resultssupporting

confidence: 88%

Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro

Priprem¹,

Khamlert²,

Radapong³

et al. 2008

American J. of Agricultural and Biological Sciences

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Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol -1 , pK a 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, fully hydrated. A receptor solution at pH 7.4 was sampled for quantification at its λ max by UV-Visible spectrophotometry and/or HPLC. The permeability coefficients of nine compounds were correlated to the n-octanol/water partition coefficients of these compounds. The permeability coefficient of these compounds using HE and SSS was correlated. Scales of shed skin from the dorsal portions of king cobras were shown to be well correlated to the human breast epidermis in this in vitro aqueous permeation study of these compounds.

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Section: Resultssupporting

confidence: 88%

Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro

Priprem¹,

Khamlert²,

Radapong³

et al. 2008

American J. of Agricultural and Biological Sciences

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“…Some scientific works (Heard et al 2003;Nanayakkara et al 2005;Puglia et al 2005;Richards et al 2006) outlined a high epithelial penetration ability of polyunsaturated fatty acids (PUFAs) and an interesting enhancement effect in the skin drug permeation. Heard and co-workers (2003), for instance, demonstrated in vitro the feasibility of the simultaneous permeation of ketoprofen, ibuprofen, and essential fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) from a formulation containing fish oil (Heard et al 2003).…”

mentioning

confidence: 99%

Effect of Polyunsaturated Fatty Acids and Some Conventional Penetration Enhancers on Transdermal Delivery of Atenolol

Puglia

Bonina

2008

Drug Delivery

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“…Drugs are considered to penetrate through the skin by one of three pathways: the polar, non-polar, or polar/non-polar route depending on their physicochemical properties, in which the molecular weight and log K o/w of drugs are thought to be the key factor (55,56). In this study, the molecular weight of the drugs, however, may have no significant effect on the penetration rate of drugs due to the relatively narrow range of molecular weight (200-500 g/mol; 57).…”

Section: Correlation Between Enhancement Efficacy Of Lactate Esters Amentioning

confidence: 99%

In vitro Enhancement of Lactate Esters on the Percutaneous Penetration of Drugs with Different Lipophilicity

et al. 2010

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Abstract. Lactate esters are widely used as food additives, perfume materials, medicine additives, and personal care products. The objective of this work was to investigate the effect of a series of lactate esters as penetration enhancers on the in vitro skin permeation of four drugs with different physicochemical properties, including ibuprofen, salicylic acid, dexamethasone and 5-fluorouracil. The saturated donor solutions of the evaluated drugs in propylene glycol were used in order to keep a constant driving force with maximum thermodynamic activity. The permeability coefficient (K p ), skin concentration of drugs (SC), and lag time (T), as well as the enhancement ratios for K p and SC were recorded. All results indicated that lactate esters can exert a significant influence on the transdermal delivery of the model drugs and there is a structure-activity relationship between the tested lactate esters and their enhancement effects. The results also suggested that the lactate esters with the chain length of fatty alcohol moieties of 10-12 are more effective enhancers. Furthermore, the enhancement effect of lactate esters increases with a decrease of the drug lipophilicity, which suggests that they may be more efficient at enhancing the penetration of hydrophilic drugs than lipophilic drugs. The influence of the concentration of lactate esters was evaluated and the optimal concentration is in the range of 5∼10 wt.%. In sum, lactate esters as a penetration enhancer for some drugs are of interest for transdermal administration when the safety of penetration enhancers is a prime consideration.

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The effect of unsaturated fatty acids in benzyl alcohol on the percutaneous permeation of three model penetrants

Cited by 46 publications

References 36 publications

Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro

Comparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitro

Effect of Polyunsaturated Fatty Acids and Some Conventional Penetration Enhancers on Transdermal Delivery of Atenolol

In vitro Enhancement of Lactate Esters on the Percutaneous Penetration of Drugs with Different Lipophilicity

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