The effect of unilateral neurotoxic lesions to serotonin fibres in the medial forebrain bundle on the metabolism of [3H]DOPA in the telencephalon of the living rat

Elevated [18F]Fluorodopamine Turnover in Brain of Patients with Schizophrenia: An [18F]Fluorodopa/Positron Emission Tomography Study

“…Furthermore, the magnitude of K was also elevated in extrastriatal structures, i.e., amygdala and midbrain of the patients. Trapping of DOPA decarboxylase substrates may also be associated with serotonin innervations in ex- trastriatal regions (Cumming et al, 1997;Brown et al, 1999). Thus, the extrastriatal findings in the present study may in part reflect the composite contributions of serotonin and dopamine fibers to FDOPA metabolism, especially, perhaps, in the amygdala.…”

“…the several pools of deaminated metabolites, regardless of their site of formation (Cumming et al, 1997;Deep et al, 1997a,b). The magnitude of the ratio K/k loss is a quantitative measurement of the distribution volume specifically for decarboxylated FDOPA metabolites trapped in brain, and the ratio K/k loss was defined as the steady-state effective distribution volume (EDV, ml/g) in this article, following our previous definition (EDV 2 , ml/g) and modified from a similar method using subtraction of total cerebellum radioactivity (Martin et al, 1989;Holden et al, 1997;Sossi et al, 2001) The "content" of brain radioactivity then includes the effective plasma volume (V 0 , ml/g), the distribution volume of the precursor pool (V f , ml/g) (which approaches a constant after 10 -20 min after the tracer administration), and the EDV (ml/g).…”

MDMA-evoked changes in the binding of dopamine D2receptor ligands in striatum of rats with unilateral serotonin depletion

“…To test these hypothesis, we first carried out consecutive microPET studies to assess the unknown test-retest stability of [ 11 C]NMSP binding in striatum of intact rats undergoing prolonged isoflurane anesthesia. Once this stability was established, another group of rats were pretreated with the selective neurotoxin 5,7-dihydroxytryptamine (Baumgarten et al, 1973), delivered as unilateral infusions to the left medial forebrain bundle (Cumming et al, 1997) in order to lesion selectively the serotonin innervation in the left hemisphere. Approximately 2 weeks after the hemilesions (Fig.…”

On the Rate of Decarboxylation of Dopa to Dopamine in Living Mammalian Braina

“…However, 5‐hydroxy‐[ 11 C]tryptophan uptake was also reduced in monkeys treated with the selective neurotoxin MPTP, 77 indicating that the nigrostriatal dopamine innervatino plays a role in the decarboxylation of this tracer. The converse may not be true: selective destruction of the serotonin innervation did not substantially alter the in vivo synthesis of [ 3 H]dopamine from [ 3 H]dopa in living rat striatum 78 . However, synthesis of [ 3 H]dopamine in olfactory tubercle and amygdala, where the serotonin innervation is more dense than is the dopamine innervation, was sensitive to destruction of serotonin fibers.…”