The Effect of Ultraviolet Light on Biorepulsive Hydrogel Poly(ethylene glycol) Films

Zhao, Zhiyong; Yan, Rui; Zharnikov, Michael

doi:10.1021/acsapm.1c00381

Cited by 10 publications

(20 citation statements)

References 61 publications

(161 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…In contrast to electron irradiation, the exposure of the PEG films to UV light does not result in their modification but only in a partial loss of material [ 18 ]. However, the mechanism behind the respective decomposition of the PEG network, which follows zero-order kinetics [ 18 ], is still unclear. Interestingly, the exposure of closely related, PEG-substituted self-assembled monolayers (SAMs) to UV light results in the same effect as their exposure to electrons, viz.…”

Section: Resultsmentioning

confidence: 99%

“…Representative ∆ p vs. h plots for the pristine and exposed-to-UV-light PEG membranes are shown in Figure 9 a; the decrease in the membrane thickness, given in the legend, manifests the expected effect of UV light [ 18 ]. The experimental points for all the samples lie quite close to each other, which suggests a similarity of the elastic properties.…”

Section: Resultsmentioning

confidence: 99%

“…These films exhibit pronounced bioinert and hydrogel properties and their characteristics could be flexibly tuned by varying the parameters of the preparation procedure [ 15 ] and the molecular weight of the precursors [ 16 ]. Further options are provided by the creation of hybrid materials on the basis of these films [ 15 ], their decoration with bioreceptors [ 8 ], and their modification by electron irradiation and UV light [ 17 , 18 ], paving the way to a variety of lithographic applications.…”

Section: Introductionmentioning

confidence: 99%

“…These issues are specifically addressed in the present study in which we also explore the possibility of tuning the elastic properties of the PEG membranes by the modification of the parent films by electron irradiation and UV light. The latter experiments, in combination with additional measurements, also shed some light onto the effect of UV light on PEG materials, which is still controversially discussed in the community [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Elastic Properties of Poly(ethylene glycol) Nanomembranes and Respective Implications

Zhao

Zharnikov

2022

Membranes

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Free-standing poly(ethylene glycol) (PEG) membranes were prepared from amine- and epoxy-terminated four-arm STAR-PEG precursors in a thickness range of 40–320 nm. The membranes feature high stability and an extreme elasticity, as emphasized by the very low values of Young’s modulus, varying from 2.08 MPa to 2.6 MPa over the studied thickness range. The extreme elasticity of the membranes stems from the elastomer-like character of the PEG network, consisting of the STAR-PEG cores interconnected by crosslinked PEG chains. This elasticity is only slightly affected by a moderate reduction in the interconnections at a deviation from the standard 1:1 composition of the precursors. However, both the elasticity and stability of the membranes are strongly deteriorated by a strong distortion of the network imposed by electron irradiation of the membranes. In contrast, exposure of the membranes to ultraviolet (UV) light (254 nm) does not affect their elastic properties, supporting the assumption that the only effect of such treatment is the decomposition of the PEG material with subsequent desorption of the released fragments. An analysis of the data allowed for the exclusion of so called “hot electrons” as a possible mechanism behind the modification of the PEG membranes by UV light.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elastic Properties of Poly(ethylene glycol) Nanomembranes and Respective Implications

Zhao

Zharnikov

2022

Membranes

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Production of Polymer Hydrogel Composites and Their Applications

Sayed

2023

J Polym Environ

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Hydrogels are three-dimensional cross-linked stable network insoluble in water, which gives them a remarkable capacity to absorb both water and biological fluids. Hydrogel has been synthesized from natural or synthetic polymers and/or monomers, which have made tremendous advancements in many different applications. Composite hydrogel is a type of hydrogel prepared by grafting hydrophilic groups, such as hydroxyl (–OH), carboxylic acid (–COOH), imide (–CONH), sulfonic acid (–SO3H), amine (–NH2), and amide (–CONH2), into the polymer chain’s backbone and adding some additives such as kaolin, zeolite, or even different types of nanoparticles. Whereas the polymeric composite hydrogels exhibit stimuli for different properties such as pH, temperature, or light, which may affect swelling, mechanical properties, and self-healing, which in turn play vital roles in different areas. Hence, numerous efforts have been made to synthesize polymer-based composited hydrogels via physical or chemical crosslinking techniques to enhance their physiochemical, biological, and many other properties. Many researchers are currently paying attention to hydrogels and their applications, including wastewater treatment and purification, medical and biomedical applications, agricultural applications, and many other industrial applications. The aim of this review is to summarize the classification of composite hydrogels based on their chemical and physical crosslinking techniques, in addition to the different polymers and additives used to prepare composite hydrogels. Furthermore, the impact of hydrogel on health and the environment has been discussed. Other significant issues were also presented, including the challenges that face hydrogel production and application, which have been discussed.

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From “stars” to nano: Porous poly(ethylene glycol) hydrogel films and nanosheets as a versatile platform for sensing and nanofabrication

Zharnikov

2024

Nano Res.

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The use of bioinert materials is crucially important for medicine and bioengineering. The most popular systems in this context are oligo- and poly(ethylene glycols) (OEGs and PEGs), applied generally in different forms as bulk materials, thin films, and functional molecular groups. Here, I review the fabrication, properties, and applications of porous hydrogel PEG films (PHFs) and nanosheets (PHNs) formed by thermally activated crosslinking of amino- and epoxy-terminated, star-branched PEG oligomers with variable molecular weight. These systems possess various useful characteristics, including tunable thickness and porosity, hydrogel properties, bioinertness, robustness, and extreme elasticity. They can serve as the basis for composite materials, advanced nanofabrication, and lithography, bioinert supports for high-resolution transmission electron microscopy, susceptible elements in micro-electromechanical systems, and basic building blocks of temperature, humidity, chemical, and biological sensors. Representative examples of the respective applications are provided. Even though these examples span a broad field-from nanoengineering to biosensing, the applications of the PHFs and PHNs are certainly not limited to these cases but can be specifically adapted and extended to other fields, such as tissue engineering and drug delivery, relying on versatility and tunability of these systems.

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The Effect of Ultraviolet Light on Biorepulsive Hydrogel Poly(ethylene glycol) Films

Cited by 10 publications

References 61 publications

Elastic Properties of Poly(ethylene glycol) Nanomembranes and Respective Implications

Elastic Properties of Poly(ethylene glycol) Nanomembranes and Respective Implications

Production of Polymer Hydrogel Composites and Their Applications

From “stars” to nano: Porous poly(ethylene glycol) hydrogel films and nanosheets as a versatile platform for sensing and nanofabrication

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