The Effect of Ultrasound-Guided Erector Spinae Plane Block Combined with Dexmedetomidine on Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial

Wang, Xunxun; Guo, R. S.; Chen, Xia; Xie, Cuiyu; Wang, Jing; Liu, Xuesheng; Lu, Yao; Fang, Weiping

doi:10.1007/s40122-020-00234-9

Cited by 32 publications

(66 citation statements)

References 28 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PONV was insignificantly different between both groups. Wang et al [13] assessed the role of adding dexmedetomidine 1 μg/kg to ESPB compared to ESPB without dexmedetomidine after modified radical mastectomy. Their results agreed ours as they demonstrated that VAS at rest and an active state was significantly lower with dexmedetomidine group at most times of measurement.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided erector spinae plane block for post thoracotomy pain: Randomized controlled study

Elshal

Gamal

Ahmed

et al. 2021

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

Background: Poor management of postoperative pain results in physiological and psychological side effects with higher morbidity. Erector spinae plane block (ESPB) has shown efficacy in controlling pain in many surgeries. Dexmedetomidine has improved the quality of analgesia in many regional techniques. This study aimed to assess the analgesic outcome of adding dexmedetomidine to bupivacaine in ultrasound (US) guided ESPB for perioperative analgesia for thoracic cancer surgeries. Patients and Methods: In this randomized controlled, double-blind study, 42 patients aged 18-65 years, ASA (American Society of Anesthesiologists) physical status II, scheduled for thoracotomy for cancer surgeries under general anesthesia were included. Patients were allocated into two equal groups: group 1 (ESPB by 28 ml bupivacaine 0.25% + 2 mL saline) and group 2 (ESPB 28 ml bupivacaine 0.25% + 2 mL dexmedetomidine 0.5 µg/kg). Blocks were performed before anesthesia induction. Results: Group 2 consumed lower intraoperative fentanyl and postoperative morphine and had a lower pain score at rest and cough compared to group 1. Group 2 had prolonged time to first request of rescue analgesia compared to group 1. Postoperative nausea and vomiting, and sedation were comparable between both groups. No block-related complications were observed. Conclusions: Adding dexmedetomidine to bupivacaine in US-guided ESPB provided more effective and safe analgesia in thoracotomy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Blocks were performed with a US machine (Sonosite Edge; Sonosite Inc., USA) equipped with an HFL38X high-frequency linear transducer (13)(14)(15)(16). With patients in sitting position, the transducer was positioned longitudinally 3 cm lateral to the T5 spinous process.…”

Section: The Us Guided Espbmentioning

confidence: 99%

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided erector spinae plane block for post thoracotomy pain: Randomized controlled study

Elshal

Gamal

Ahmed

et al. 2021

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Craniocerebral surgery is required for brain tumors, severe brain trauma, cranial deformation, encephalorrhagia, and other diseases, which is a common brain surgery, but with a high risk due to the special surgical sites [ 13 – 15 ]. Before surgery, patients should be routinely examined to select the appropriate anesthesia and surgical methods, mainly including the detection of the cerebral metabolism, intracranial pressure, and cerebral blood flow.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery

Yang

Zhang

2021

BioMed Research International

View full text Add to dashboard Cite

Objective. To study the effects of dexmedetomidine in combination with ropivacaine in patients undergoing craniocerebral surgery and their efficiency on cognitive function and inflammatory response of patients. Methods. 100 patients undergoing craniocerebral surgery in our hospital from November 2018 to September 2020 were randomly selected and divided into a control group and an experimental group by drawing lots, with 50 cases in each group. Patients in the control group received routine anesthesia, while those in the experimental group received 1 μg/kg of dexmedetomidine combined with 0.5% of ropivacaine for anesthesia to compare the anesthesia onset time, analgesic time, postoperative awake time, Social Disability Screening Schedule (SDSS) cognitive function score after waking, visual analogue scale (VAS) pain score, Ramsay sedation score, incidence of adverse reactions, postoperative inflammatory factor expression levels, and changes in heart rate, oxygen saturation, and blood pressure at T0, T1, T2, T3, and T4 between the two groups. Results. The anesthesia onset time, SDSS cognitive function score after waking, VAS pain score, Ramsay sedation score, incidence of adverse reactions, and postoperative inflammatory factor expression levels in the experimental group were significantly lower than those in the control group ( P < 0.05 ). The analgesic time and postoperative awake time in the experimental group were significantly longer than those in the control group, with statistical significance ( P < 0.05 ). There were no statistically significant differences in the changes of heart rate, oxygen saturation, and blood pressure at T0, T1, T2, T3, and T4 between the two groups ( P > 0.05 ). Conclusion. Dexmedetomidine combined with ropivacaine has high application value in craniocerebral surgery.

show abstract

“…[16][17][18] Wang et al found that ropivacaine with dexmedetomidine in ESPB for modified radical mastectomy (MRM) was found to decrease VAS and analgesic consumption in the postoperative period when compared to plain ropivacaine without any adjunct. 19 Similar to dexmedetomidine, dexamethasone has also been in used in regional anaesthesia as additive for a very long period of time. 20 Dexamethasone which is a glucocorticoid exerts its action by decreasing perineural edema, decreasing systemic absorption of LA by inducing vasoconstriction and directly acting on nerves to reduce neural discharge and suppressing pain signal transmission.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine versus dexamethasone as adjunct to ropivacaine in erector spinae plane block for patients undergoing breast surgery: a randomized, prospective, double blinded study

Basing¹,

Deka²,

Majumdar³

2021

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Loco-regional anaesthesia (GA) has been extensively applied in the clinical field for achieving post-operative analgesia. Erector spinae plane block (ESPB) which is a novel inter-fascial plane block has been widely used for breast surgery. Dexmedetomidine and dexamethasone as an adjunct to local anaesthesia have been widely reported to reduce postoperative pain and analgesic consumption but there are no studies comparing both these drugs in ESPB for breast surgery.Methods: Sixty ASA I-II patients scheduled for breast surgery were randomly allocated into two groups-Group DX and group DM. Group DX received 20 ml ropivacaine 0.2% with dexmedetomidine 0.5 mcg/kg while group DM received 20 ml ropivacaine 0.2 % with 8 mg dexamethasone in ESPB preemptively. All the patients were induced with standard GA and extubated at the end of surgery. In the post-operative period visual analogue scale (VAS) pain score, total tramadol consumption, time for first rescue analgesia and side effects were noted for 24 hours.Results: The demographical parameters were comparable between both the groups. The VAS score, total tramadol consumption and time for first rescue analgesia were both similar in both the groups without any significant difference. No side effects were noted in any patients in both the groups.Conclusions: Dexmedetomidine (0.5 mcg/kg) and dexamethasone (8 mg) as an adjunct to ropivacaine reduces postoperative pain and analgesic consumption with no significant difference when used in ESPB for patients undergoing breast surgery without any side effects.

show abstract

The Effect of Ultrasound-Guided Erector Spinae Plane Block Combined with Dexmedetomidine on Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial

Cited by 32 publications

References 28 publications

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided erector spinae plane block for post thoracotomy pain: Randomized controlled study

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided erector spinae plane block for post thoracotomy pain: Randomized controlled study

[Retracted] Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery

Dexmedetomidine versus dexamethasone as adjunct to ropivacaine in erector spinae plane block for patients undergoing breast surgery: a randomized, prospective, double blinded study

Contact Info

Product

Resources

About