The effect of ultrasound assisted extraction on structural composition, antioxidant activity and immunoregulation of polysaccharides from Ziziphus jujuba Mill var. spinosa seeds

Lin, Tingting; Liu, Yan; Lai, Chang-Jiang-Sheng; Yang, Tingting; Xie, Junbo; Zhang, Yanqing

doi:10.1016/j.indcrop.2018.08.078

Cited by 97 publications

(42 citation statements)

References 33 publications

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“…Western blot test showed that ZS polysaccharides could significantly promote the release of NO and the expression of stress response protein (COX-2 and iNOS) in RAW264.7 cells. In addition, ZS polysaccharides could significantly promote the phosphorylation of I κ B- α and ERK protein, which also indicated that the polysaccharide has a certain immunomodulatory effect [ 77 ].…”

Section: Pharmacologymentioning

confidence: 99%

Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review

Zhao

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Ziziphi Spinosae Semen (ZS, the seeds of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou) is used as a traditional Chinese medicine referred to as Suan zao ren (酸枣仁). This paper aims to provide a systematic review of its traditional uses and its botanical, phytochemical, pharmacological, pharmacokinetic, and toxicological characteristics. The future development and research prospects for ZS have also been discussed in detail. To date, over 150 compounds have been identified in this plant, including terpenoids, alkaloids, flavonoids, fatty acids, volatile oils, polysaccharides, and others. Both extracts and purified compounds have excellent biological activities, especially sedative and hypnotic effects. Other effects include ameliorating effect of learning and memory, anti-inflammation, antioxidation, blood pressure and lipid lowering, antiaging, and antitumor effects. Thus, this traditional Chinese medicine can be used to treat many diseases such as insomnia, forgetfulness, headaches, and dizziness. Although many of the traditional uses of ZS are well established, the relationship between structure and function still needs to be further studied. In order to better pave the way for research and the establishment of quality control standards for ZS, it will be very important to elucidate its pharmacological mechanisms of action and explore new clinical effects.

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Section: Pharmacologymentioning

confidence: 99%

Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review

Zhao

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Spinosa (Bunge) Hu ex. H.F. Chou (Rhamnaceae), which has been widely used as a herb in traditional Chinese medicine to treat insomnia and anxiety (Lin et al., 2018; Sun, Liu, Xu, Yan, & Xie, 2014). The flavonoids were commonly considered as the main constituents responsible for its clinical effect (Chen, Lee, Huang, Kuan, & Chen, 2015).…”

Section: Introductionmentioning

confidence: 99%

6ʹʺ‐p‐Coumaroylspinosin protects PC12 neuronal cells from acrylamide‐induced oxidative stress and apoptosis

Zhou

Cui

et al. 2020

J Food Biochem

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6ʹʺ‐p‐coumaroylspinosin (P‐CS) is a flavonoid isolated from Ziziphi Spinosae Semen (ZSS), whereas, the antioxidative activity has not been reported. Oxidative stress is believed to be one of the main causes of neurodegenerative disorders. In this study, the antioxidative effect of P‐CS on PC12 cells was determined. The cells were treated with acrylamide (AA) in the absence or presence of P‐CS, and cell apoptosis was analyzed. Interestingly, P‐CS pretreatment of the cells could significantly prevent AA‐induced cell death, glutathione (GSH) contents decrease, and reactive oxygen species (ROS) overproduction. Further investigation of the molecular mechanism underlying the effect of P‐CS on cell apoptosis revealed that P‐CS was able to suppress the expression of Bax and Bim induced by AA and inhibit the JNKs pathway. Our findings support a role of P‐CS in preventing neuronal cell apoptosis induced by AA, suggesting its therapeutic potential for the treatment of neurodegenerative disorders as a medicinal supplement. Practical applications Oxidative stress is believed to cause damage in subcellular organelles, nucleic acids, and alteration in protein aggregation as well as disruption of the signaling cascades associated with aging and apoptosis. A small molecule, non‐poisonous natural antioxidant is needed to protect the brain from oxidative stress. Compared with western medicine, natural products carry less risk of adverse effects and are not too expensive, especially for the third‐world countries. Furthermore, ZSS could be used to produce or prepare antioxidants, such as P‐CS, which has been reported significant anti‐oxidative activity in this study.

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“…Ziziphus jujuba var. spinosa seeds polysaccharides also could enhance cell viability by reducing the leaping ROS [ 25 ]. Therefore, PBE might protect Hela cells by lowering the increasing ROS level.…”

Section: Resultsmentioning

confidence: 99%

The Antioxidant Capacity In Vitro and In Vivo of Polysaccharides From Bergenia emeiensis

Zeng

Feng

2020

IJMS

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Polysaccharides from Bergenia emeiensis (PBE) showed a robust antioxidant ability on scavenging free radicals in vitro. However, the further antioxidant potential in cell level and in vivo was still unknown. Therefore, in this present study, the protective effect of PBE on human cervical carcinoma cell (Hela) cells and Caenorhabditis elegans against oxidative stress was evaluated. The results showed PBE could reduce the reactive oxygen species (ROS) level in Hela cells and promote the mitochondrial membrane potential. Then, the cell apoptosis was reduced. Moreover, PBE could enhance the survival of C. elegans under thermal stress to 13.44%, and significantly reduce the ROS level, which was connected with the overexpression of sod-3 and the increased nuclear localization of daf-16 transcription factor. Therefore, PBE exhibited a strong antioxidant capacity in the cellular level and for a whole organism. Thus, polysaccharides from B. emeiensis have natural potential to be a safe antioxidant.

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The effect of ultrasound assisted extraction on structural composition, antioxidant activity and immunoregulation of polysaccharides from Ziziphus jujuba Mill var. spinosa seeds

Cited by 97 publications

References 33 publications

Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review

Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics of Ziziphi Spinosae Semen: A Review

6ʹʺ‐p‐Coumaroylspinosin protects PC12 neuronal cells from acrylamide‐induced oxidative stress and apoptosis

The Antioxidant Capacity In Vitro and In Vivo of Polysaccharides From Bergenia emeiensis

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