The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL

Kanoke, Atsushi; Nishijima, Yasuo; Ljungberg, Magnus; Omodaka, Shunsuke; Yang, Shih Yen; Wong, SuWai; Rabiller, Gratianne; Tominaga, Teiji; Hsieh, Christine L.; Liu, Jialing

doi:10.1016/j.expneurol.2020.113461

Cited by 11 publications

(11 citation statements)

References 47 publications

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“…7 . Since CD36 plays a vital role in innate immunity 72 , 73 , 74 and innate immune cells can produce a wide range of inflammatory cytokines, 75 future studies are needed to address the expression of CD36 on innate immune cells and its relationships with other inflammatory factors. There are some discrepancies between our results and those that have been published.…”

Section: Discussionmentioning

confidence: 99%

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

Xiao¹,

Yan²,

Han³

et al. 2022

eBioMedicine

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Section: Discussionmentioning

confidence: 99%

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

Xiao¹,

Yan²,

Han³

et al. 2022

eBioMedicine

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“…These results reinforce the findings of Madrigal and colleagues where sCD36 conversely associates with WC, total body fat mass, body fat index, and LDL-c, among other metabolic parameters in Mexican populations 9 . Some studies suggested that CD36 deficiency could be detrimental on human health, indeed, it was observed that CD36 deficient individuals present higher HbA1c plasma levels, IR, and significantly increased rate of morbidity by cardiovascular complications 12 . Low CD36 expression levels can be result of the CD36 internalization in adipose tissue in response to excess of FA during lipolysis in an IR state, accompanied by the decrease of adiponectin production 10 .…”

Section: Discussionmentioning

confidence: 99%

Low CD36 monocyte expression levels are associated with overweight in Mexicans with type 2 diabetes

Martín-Márquez¹,

Mercado²,

Sánchez‐Hernández³

et al. 2022

RME

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Objective:To analyze the association of body weight, glucose and oxidized LDL (ox-LDL) on the expression of CD36 in monocytes in Mexican patients with type 2 diabetes mellitus (T2D). Methods: 115 individuals without diabetes and patients with TD2 with normal weight and overweight were included in a cross-sectional study. Results: Low expression of CD36 was observed in subjects without diabetes and patients with T2D who were overweight compared to normal-weight. Conclusion: Patients with T2D and subjects with overweight without diabetes presented low levels of CD36 expression.

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“…Human macrophage phagocytosed aged neutrophils without inflammatory responses. 54 Obesity and diabetes can alter immune function and adipocyte size by several mechanisms. Adipokine can affect adipocyte size, with increase in adipocyte size and increase secretion of macrophage inflammatory protein 1β, IL-1RA, CCL2.…”

Section: The Inflammatory Responsementioning

confidence: 99%

Which BMI for Diabetes Patients is Better? From the View of the Adipose Tissue Macrophage-Derived Exosome

Liu¹,

H²,

Y³

et al. 2022

DMSO

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Diabetes, as a group of metabolic diseases, can elevate blood glucose, thus leading to the development of life-threatening complications. It is difficult to define the outcome for diabetics with different BMI. This review will illustrate the adipose tissue macrophagederived exosome in the diabetics with different BMI. Patients and Methods: Insulin resistance in peripheral tissues can cause diabetes. The peripheral tissues include liver, muscle, or the adipose depots. Communication between these organs is fatal to the maintenance of glucose homeostasis. This review will illustrate this communication. Obesity is closely linked with diabetes. There are different changes in fat distribution in diabetic patients. Adipose tissue macrophages can secrete various hormones, including adiponectin, leptin, resistin and other classical cytokines, such as TNF-α and IL-6. Studies illustrated that exosomes from the adipose tissue, can modulate inter-organ cross-talk by regulating gene expression in other tissues. Results: Adipose tissue macrophages exosomes links thin and fat individuals in the development of diabetes. Conclusion:The molecular pathways initiated by exosomes such as miRNA in the situations of metabolic stress could help us gain a deeper knowledge of the pathophysiology of diabetes.

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The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL

Cited by 11 publications

References 47 publications

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

Low CD36 monocyte expression levels are associated with overweight in Mexicans with type 2 diabetes

Which BMI for Diabetes Patients is Better? From the View of the Adipose Tissue Macrophage-Derived Exosome

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