The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial

Madero, Magdalena; Arriaga, Julio C.; Jalal, Diana; Rivard, Christopher J.; McFann, Kim; Pérez-Méndez, Óscar; Vázquez, Armando Gómez; Ruiz, Arturo; Lanaspa, Miguel A.; Jimenez, Carlos Roncal; Johnson, Richard J.; Lozada, Laura-Gabriela Sánchez

doi:10.1016/j.metabol.2011.04.001

Cited by 110 publications

(100 citation statements)

References 25 publications

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“…We did not see such an effect in the present analysis. Five of the isocaloric trials that are included in our analysis that measured uric acid showed no significant change 15,17,[33][34][35] ; however, the fructose dose in these studies was Ͻ200 g and when compared with other sources of carbohydrates. Whether these mechanisms are sufficient to exert chronic and clinically significant effects on BP in humans is uncertain.…”

Section: Discussionmentioning

confidence: 87%

“…Second, only 2 hypercaloric studies assessed MAP, and only 1 of the hypercaloric studies reported SBP and DBP. Third, the data provided by Madero et al 34 must be interpreted carefully. Although this study met all of our specified inclusion criteria, they used fruits as a vehicle for fructose administration.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining 16 reports were reviewed in full. A total of 11 reports were selected for analysis, providing data for 15 trials: 13 isocaloric 14,15,17,27,28,[32][33][34][35][36] and 2 hypercaloric feeding trials, 27,37 with a median follow-up of 4.0 weeks (range: 15.5 days to 10 weeks).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…The use of broader correlation coefficients (0.25 and 0.75) did not alter these main findings; however, using correlation coefficient of 0.75, interstudy heterogeneity became significant in the overall analysis (data not shown). Sensitivity analyses in which each individual study was systematically removed, and the effect estimate recalculated without it, showed that the removal of Madero et al 34 resulted in a significant SBP-lowering effect in the nondiabetic stratum and the overall analysis.…”

Section: Isocaloric Feeding Trialsmentioning

confidence: 99%

“…The use of broader correlation coefficients (0.25 and 0.75) did not alter these findings. Sensitivity analysis in which each individual study was systematically removed showed that the removal of Madero et al, 34 Silbernagel et al, 35 or Koh et al 17 resulted in the loss of significance in the overall analysis. A priori subgroup analyses were carried out using data from only isocaloric trials in nondiabetes to explore effect modifiers of fructose on MAP ( Figure S3).…”

Section: Mean Arterial Pressurementioning

confidence: 99%

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Effect of Fructose on Blood Pressure

et al. 2012

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Abstract-Concerns have been raised about the adverse effect of fructose on blood pressure. International dietary guidelines, however, have not addressed fructose intake directly. A systematic review and meta-analysis was conducted to assess the effect of fructose in isocaloric exchange for other carbohydrates on systolic, diastolic, and mean arterial blood pressures. Studies were identified using Medline, Embase, and Cochrane databases (through January 9, 2012). Human clinical trials of isocaloric oral fructose exchange for other carbohydrate sources for Ն7 days were included in the analysis. Data were pooled by the generic inverse variance method using random-effects models and expressed as mean differences with 95% CI. Heterogeneity was assessed by the Q-statistic and quantified by I 2 . Study quality was assessed using the Heyland Methodological Quality Score. Thirteen isocaloric (nϭ352) and 2 hypercaloric (nϭ24) trials met the eligibility criteria. Overall, fructose intake in isocaloric exchange for other carbohydrates significantly decreased diastolic (mean difference: Ϫ1.54 [95% CI: Ϫ2.77 to Ϫ0.32]) and mean arterial pressure (mean difference: Ϫ1.16 [95% CI: Ϫ2.15 to Ϫ0.18]). There was no significant effect of fructose on systolic blood pressure (mean difference: Ϫ1.10 [95% CI: Ϫ2.46 to 0.44]). The hypercaloric fructose feeding trials found no significant overall mean arterial blood pressure effect of fructose in comparison with other carbohydrates. To confirm these results, longer and larger trials are needed. Contrary to previous concerns, we found that isocaloric substitution of fructose for other carbohydrates did not adversely affect blood pressure in humans.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Isocaloric Feeding Trialsmentioning

confidence: 99%

Section: Mean Arterial Pressurementioning

confidence: 99%

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Effect of Fructose on Blood Pressure

et al. 2012

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High versus low-added sugar consumption for the primary prevention of cardiovascular disease

Bergwall

Johansson

Sonestedt

et al. 2022

Cochrane Database of Systematic Reviews

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Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

2016

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Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal. Several controlled studies have confirmed that an intense approach to lifestyle changes, carried on along the lines of cognitive-behavior treatment, is able to attain the desired 7%-10% weight loss, associated with reduced liver fat, nonalcoholic steatohepatitis (NASH) remission, and also reduction of fibrosis. Even larger effects are reported after bariatric surgery-induced weight loss in NAFLD, where 80% of subjects achieve NASH resolution at 1-year follow-up. These results provide solid data to evaluate the safety and effectiveness of the pharmacological treatment of NASH. The battle against metabolic diseases, largely fueled by increased liver fat, needs a comprehensive approach to be successful in an obesiogenic environment. In this review, we will discuss the role of hepatic lipid metabolism, genetic background, diet, and physical activity on fatty liver. They are the basis for a lifestyle approach

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The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial

Cited by 110 publications

References 25 publications

Effect of Fructose on Blood Pressure

Effect of Fructose on Blood Pressure

High versus low-added sugar consumption for the primary prevention of cardiovascular disease

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

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