<b><i>Background:</i></b> Associations of polymorphisms in interferon-gamma (IFNG), interleukin-10 (IL-10), and interleukin-18 (IL-18) with coronary artery disease (CAD) have already been investigated by many studies, yet the findings of these studies have been somewhat inconsistent. <b><i>Objectives:</i></b> The aim of this meta-analysis was to better clarify associations between polymorphisms in <i>IFNG/IL-10/IL-18</i> and CAD by combing the results of all relevant articles. <b><i>Methods:</i></b> Eligible articles were searched from PubMed, EMBASE, WOS, and CNKI. We used Review Manager to combine the results of individual studies. <b><i>Results:</i></b> Fifty-one studies were included in this meta-analysis. Combined results revealed that <i>IFNG</i> rs243056, <i>IL-10</i>rs1800871, <i>IL-18</i>rs187238, <i>IL-18</i>rs1946518, and <i>IL-18</i>rs1946519 polymorphisms were all significantly associated with CAD in the general population. We also obtained similar significant results for <i>IFNG</i> rs243056, <i>IL-10</i>rs1800871, <i>IL-10</i> rs1800896, <i>IL-18</i>rs187238, <i>IL-18</i>rs1946518, and <i>IL-18</i>rs1946519 polymorphisms in Asians in further subgroup analyses. <b><i>Conclusions:</i></b> Collectively, this meta-analysis proved that <i>IFNG</i> rs243056, <i>IL-10</i>rs1800871, <i>IL-10</i> rs1800896, <i>IL-18</i>rs187238, <i>IL-18</i>rs1946518, and <i>IL-18</i>rs1946519 polymorphisms may confer susceptibility to CAD for Asians.