The Effect of Tumor Necrosis Factor-α Antagonists on Arterial Stiffness in Rheumatoid Arthritis: A Literature Review

Dulai, Rajdip; Perry, Mark; Twycross-Lewis, Richard; Morrissey, Dylan; Atzeni, Fabiola; Greenwald, Stephen E.

doi:10.1016/j.semarthrit.2012.02.002

Cited by 44 publications

(21 citation statements)

References 41 publications

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“…Tumors (Paszek et al, 2005) and metastatic lymph nodes (Choi et al, 2015) have been shown to be much stiffer than normal tissue. Furthermore, infections and TNF-mediated signaling have been shown to induce arterial stiffness (Dulai et al, 2012; Park and Lakatta, 2012; Evani et al, 2016). In these pathological conditions, tissue stiffness might play a role in modulating the efficiency of T cell scanning.…”

Section: Discussionmentioning

confidence: 99%

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

Saitakis

Dogniaux

Goudot

et al. 2017

eLife

175

168

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T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.DOI: http://dx.doi.org/10.7554/eLife.23190.001

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Section: Discussionmentioning

confidence: 99%

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

Saitakis

Dogniaux

Goudot

et al. 2017

eLife

175

168

View full text Add to dashboard Cite

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“…Substantial research has been invested into evaluating noninvasive vascular biomarkers that better reflect the added CVD risk imposed by chronic inflammation 13 . Taking into account the extent to which aPWV, AIx, cIMT, and CP have been applied in cross-sectional studies and clinical trials in rheumatology 13,15,44,45 , it is surprising Taking into account the extent to which aPWV, AIx, cIMT, and CP have been applied in cross-sectional studies and clinical trials in rheumatology 13,15,44,45 , it is surprising …”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Arterial Stiffness and Subclinical Carotid Atherosclerosis for Cardiovascular Disease in Patients with Rheumatoid Arthritis

Ikdahl

Rollefstad²,

Wibetoe³

et al. 2016

J Rheumatol

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“…Atheroma is recognized to be an inflammatory process and CRP a good predictor of cardiovascular event occurrence. Studies that assessed the effects of biotherapies (ie, rituximab, tocilizumab, or TNF-alpha inhibitors) on aortic stiffness in RA revealed variable changes in PWV or augmentation index, but most of the time found an improvement in aortic stiffness, with a significant decrease in systemic inflammation 12–14…”

Section: Discussionmentioning

confidence: 99%

“…Regarding anti-TNF-alpha treatment, the effects of this on aortic stiffness remain controversial, but a recent literature review suggests there may be a beneficial effect 12. Changes in the lipid profile after TNF-alpha inhibitors have also been shown to be variable.…”

Section: Discussionmentioning

confidence: 99%

Effects of 6 months of abatacept treatment on aortic stiffness in patients with rheumatoid arthritis

Mathieu

Couderc²,

Glace³

et al. 2013

BTT

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BackgroundSystemic inflammation plays an important role in the increased cardiac risk observed in rheumatoid arthritis (RA). Effective control of inflammation and disease activity may be of benefit in reducing cardiovascular risk in RA patients.ObjectiveOur study was conducted in patients with active RA to investigate the effects of 24-week abatacept treatment on aortic stiffness measured by pulse wave velocity (PWV).ResultsThe study included 21 patients, of whom 17 were females, with a mean age of 65.2±13.7 years. Ten patients had positive rheumatoid factors, 16 positive anti-citrullinated protein antibodies, and 19 presented an erosive form of RA. Sixteen patients were nonresponders to anti-tumor necrosis factor-alpha treatments. After 6 months of abatacept treatment, there was a significant increase in PWV levels (9.8±2.9 versus 8.5±3.9 m/second; P=0.02). A nonsignificant increase in total cholesterol and low-density lipoprotein cholesterol was observed. There was also a significant increase in high-density lipoprotein cholesterol levels, which led to a nonsignificant decrease in atherogenic index. The improvement in disease activity was significant, and there was a decrease of systemic inflammatory parameters, but without reaching statistical significancy. Changes in PWV were significantly correlated with changes in Disease Activity Score on 28 joints based on erythrocyte sedimentation rate (r=0.46; P=0.035) and in high-density lipoprotein cholesterol (r=−0.38; P=0.046). No correlation was observed with changes in C-reactive protein and in other parameters of lipid profile or in steroid dose.ConclusionThe worsening of aortic stiffness found after 6 months of abatacept therapy might be due to an insufficient decrease in systemic inflammation.

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The Effect of Tumor Necrosis Factor-α Antagonists on Arterial Stiffness in Rheumatoid Arthritis: A Literature Review

Cited by 44 publications

References 41 publications

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

Predictive Value of Arterial Stiffness and Subclinical Carotid Atherosclerosis for Cardiovascular Disease in Patients with Rheumatoid Arthritis

Effects of 6 months of abatacept treatment on aortic stiffness in patients with rheumatoid arthritis

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