The Effect of Tubing Dwell Time on Insulin Adsorption During Intravenous Insulin Infusions

Abstract

Background: Insulin adsorbs to plastic tubing, which decreases the concentration of an insulin solution delivered from an intravenous infusion set. Dwelling insulin within tubing before starting the infusion decreases adsorption but delays treatment initiation and wastes time in infusion preparation. The lack of data on dwell time effects results in wide variability in practice. We aim to determine the effect of dwell time on insulin concentration from intravenous infusion tubing. Materials and Methods: In this in vitro study, we used insulin solutions with concentrations of 0.1 unit/mL, 1 unit/mL, and 10 units/mL. Each solution dwelled in intravenous infusion sets for 0, 15, 30, or 60 min. After the dwell, we measured insulin concentrations from the solution bags and tubing. We repeated each insulin concentration-dwell time combination five times. Comparisons were performed using analyses of variance. Results: For each of the three insulin concentrations, the mean insulin concentrations from the tubing were not significantly different between dwell times. Duration of dwell time did not affect insulin adsorption in polypropylene intravenous infusion sets. Conclusions: We recommend that following a 20-mL flush, insulin infusions can be started without any dwell time. Removal of dwell times may improve clinical practice by minimizing preparation time and will allow faster initiation of insulin infusion therapy.

Do plasticized polyvinylchloride and polyurethane infusion sets promote infliximab adsorption?

“…However, there is little information about its behaviour during infusions through infusion lines and catheters. Indeed, even though polymeric-based surfaces (polyvinyl chloride, silicone, polyurethane) are always found in medical devices used for infusion, and that they are known for interacting with small peptides, like cyclosporine or insulin [4][5][6], their potential interactions in clinical situations with mAbs has not been fully studied. As such, adsorption phenomena can be a major concern during the infusion process since the drug lost is not administered to the patient and means a loss of effectiveness of the treatment.…”

Capacity of Infusion Lines for Insulin Adsorption: Effect of Flow Rate on Total Adsorption

“…First documented in the 1960s-1970s, [1][2][3][4][5] it has recently returned to prominence with a second burst from the late 1990s to present. [6][7][8][9][10][11][12][13][14] Importantly, while the phenomenon is well documented, no methods to quantify, predict, and thus manage this loss have emerged. Given the dangers of hypoglycemia [15][16][17] and glycemic variability, [18][19][20] as well as those of line blockages for wearable insulin pumps, [21][22][23] it is a potentially significant gap with implications for modern precision insulin therapy systems.…”

Вплив Індивідуальних Особливостей Організму, Патологічних Процесів, Комбінованого Застосування Лікарських Засобів На Їх Ефективність

“…et al, 1985;Martens H.J. et al, 1990;Seifi A. et al, 2004;Thompson C. et al, 2012;Рэнки П.Дж. и соавт., 2014).…”