The effect of tubal ligation surgery during cesarean operation on dysmenorrhoea, dyspareunia and menstrual cycle

Taşkömür, Aysun Tekeli; Erten, Özlem

doi:10.1016/j.jogoh.2020.102054

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Risperidone (Ris) is a common antipsychotic drug used for treating schizophrenia; however, increases in PRL levels are common after long-term administration, leading to serious adverse reactions, such as amenorrhea, galactorrhea, anovulation and infertility ( Zhu et al, 2021 ). In addition, opioids ( Demarest et al, 2015 ), estrogen ( Ni et al, 2021 ), and contraceptives ( Taşkömür and Erten 2021 ) can increase PRL levels. We hypothesized that the increased PRL levels associated with these drugs and hormones might be related to DRD2 methylation because clinical data showed that AD-induced increases in PRL levels are associated with DRD2 methylation.…”

Section: Introductionmentioning

confidence: 99%

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms

et al. 2022

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Background: The dopamine D2 receptor (DRD2) plays an important role in the increased prolactin (PRL) levels associated with the pathogenesis of antipsychotic drugs (ADs). Elevated prolactin levels can affect people’s quality of life. Maiya alkaloids has been used to treat diseases associated with high PRL levels. Maiya, is a processed product of the mature fruits of Hordeum vulgare L. (a gramineous plant) after sprouting and drying and also a common Chinese herbal drug used in the clinic, is traditionally used to treat abnormal lactation, and is currently used clinically for the treatment of abnormal PRL levels.Aims: Epigenetic mechanisms can be related to DRD2 expression. We investigated the role of DRD2 methylation in the induction of PRL expression by ADs and the mechanism underlying the effects of total barley maiya alkaloids (TBMA) on this induction.Methods: The methylation rate of DRD2 in 46 people with schizophrenia who took risperidone was detected by MassARRAY sequencing. Humans were long term users of Ris. Seventy Sprague Dawley female rats were divided into seven groups. A rat model of risperidone-induced PRL was established, and the potential protective effects of TBMA and its components [e.g., hordenine (Hor)] on these increased PRL levels were investigated. The PRL concentration was detected by Enzyme-linked immunosorbent assay. PRL, DRD2, and DNA methyltransferase (DNMT1, DNMT3α, and DNMT3β) protein and mRNA expression were detected by western blotting and real-time polymerase chain reaction (RT-PCR), respectively. The positive rate of methylation in the DRD2 promoter region of rats was detected by MassARRAY sequencing.Results: Clinical studies showed that the positive rate of DRD2 methylation associated with increased PRL levels induced by ADs was significantly higher than in the normal prolactinemia (NPRL) group. In vivo and vitro, TBMA and Hor inhibited this induction of PRL expression and increased DRD2 expression by inhibiting the expression of the DNMTs.Conclusions: TBMA and hordenine increased DRD2 expression by inhibiting DNMT-dependent DRD2 methylation.

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Section: Introductionmentioning

confidence: 99%

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms

et al. 2022

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Assessing the impact of hormonal contraceptive use on menstrual health among women of reproductive age – a systematic review

Jahanfar,

Mortazavi,

Lapidow

et al. 2024

The European Journal of Contraception & Reproductive Health

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Psychosexual Implications of Tubal Ligation in a Sample of Iraqi Women

Al-Sattam,

Hussein,

Qasim

et al. 2024

Al-Rafidain J Med Sci

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Background: Tubal ligation, recognized as a surgical intervention that ensures permanent contraception, has established itself as an option for women seeking a definitive solution for family planning. Objective: To assess the psychosexual implications of tubal ligation in a sample of women in Baghdad, Iraq. Methods: A prospective cohort study was conducted in a teaching hospital for 2 years, from the first of January 2022 to the end of December 2023, in which 203 women who underwent tubal ligation were included. Results: In the present study, we found that 158 (77.8%) had no depression, mild depression presented in 27 (13.3%), and moderate depression in only 15 (7.4%). While 163 (80.3%) of women did not suffer from anxiety, 32 (15.8%) had mild to moderate anxiety, and only 8 (3.9%) were presented with severe anxiety. 27 (13.3%) have changed in coital frequency this this week. 49 (24.2%) have a change in sexual desire, a change in pleasure, and 37 (18.2%) suffer from a change in orgasm. Conclusions: The current study concluded that there are noticeable psychosexual effects of tubal ligation in women.

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The effect of tubal ligation surgery during cesarean operation on dysmenorrhoea, dyspareunia and menstrual cycle

Cited by 3 publications

References 22 publications

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms

Assessing the impact of hormonal contraceptive use on menstrual health among women of reproductive age – a systematic review

Psychosexual Implications of Tubal Ligation in a Sample of Iraqi Women

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