The Effect of Trypsin-Chymotrypsin on Postoperative Pain after Single Visit Endodontic Treatment: A Randomized Controlled Trial

Post-operative pain management using two drugs following dental implant surgery among Indians

“…It targets early stage of inflammation, reducing the period of fibrinolysis, as a result local microcirculation is improved reducing the extent of edema, inflammation aiding faster recovery and healing, this compound is also having analgesic but when compared to diclofenac has lesser analgesic potential. This drug is a proteolytic enzyme, and it has been observed to have an analgesic property close to that of NASIDs [ 17 ] Based on the outcomes of the current study it can be understood that a combination of NSAID and the proteolytic enzyme offers better postoperative analgesia compared to that of a single dose of acetaminophen, it was noted that the administration of the combination effectively reduce the postoperative pain sequelae at the 24 hour level waning in action and offered similar results at the end of 1 week to the stand alone drug, and the patients had an optimistic response to the drug combination, this study thus can be the basis for further investigations on wider patient population would help to add more significance to this finding.…”

Comprehensive Strategies in Endodontic Pain Management: An Integrative Narrative Review

“…The study divided 60 patients into four groups of fifteen each, with each group receiving either ibuprofen (600 mg), ambezim-G (trypsin 5 mg and chymotrypsin 5 mg), a combination of both, or a placebo, postoperatively. Participants’ pain levels were assessed at various intervals using a numerical scale [ 27 ].…”

“…However, it's important to note the limitation of the study: the sample size of 15 patients per group may not be large enough to fully represent a broader patient population. This limitation suggests that while the results are promising, further research with a larger sample size is necessary to validate these findings and to better understand the potential benefits and limitations of trypsin-chymotrypsin in endodontic pain management [ 27 ].…”