The effect of troxerutin on anxiety- and depressive-like behaviours in the offspring of high-fat diet fed dams

Abstract

This study aimed at investigating the metabolic and behavioural effects of troxerutin treatment in the offspring of high fat diet (HFD) fed dams. Female Wistar rats (n = 40) received normal diet (ND) or HFD for 8 weeks prior to breeding. After mating, pregnant animals were assigned to four subgroups: ND, ND + Tro (troxerutin 150 mg/kg/day), HFD, and HFD + Tro. On the 21st day, male offspring were weaned and fed ND until 12 weeks old. Behavioural tests were performed on postnatal day (PND) 80 and 90. Compared to the controls, the HFD offspring showed more anxiety- and depressive-like behaviours, higher blood glucose, cholesterol, and cortisol levels. On the other hand, chronic troxerutin administration during gestation restored metabolic and behavioural changes to normal. In summary, troxerutin improved anxiety- and depressive-like behaviours, as well as metabolic status in the offspring of the HFD fed dams. More studies are needed to determine the underlying mechanisms.

Fetal brain and placental programming in maternal obesity: A review of human and animal model studies

“…Depression‐like behavior has been evaluated with the Porsolt forced swim test. Multiple studies have shown that offspring of HFD dams spend less time in the open arms of the elevated plus maze compared to controls, consistent with increased anxiety 71‐77 . Anxiety‐like behavior in offspring of obese dams has also been noted in the morris water maze task, open field test, and light–dark transition tests 66,71,74 .…”

“…69 to controls, consistent with increased anxiety. [71][72][73][74][75][76][77] Anxiety-like behavior in offspring of obese dams has also been noted in the morris water maze task, open field test, and light-dark transition tests. 66,71,74. Depression-like behaviors have been observed in offspring exposed to maternal obesity and HFD on the forced swim test.…”

The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review

“…Another in vivo study with mice treated with a high-fat diet indicated that chronic administration of TRX (150 mg/kg) during the pregnancy improved anxiety- and depressive-like behaviors probably via reducing the serum levels of cortisol, glucose and cholesterol. The results suggest that these effects of TRX may be related to its anti-inflammatory and anti-oxidant properties [ 111 ].…”

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

“…It was found that these neuroprotective effects of troxerutin are mediated by modulation of endothelial nitric oxide synthase (eNOS) coupling/decoupling status that not only enhanced nitric oxide (NO), but also diminished peroxynitrate level expression. Bayandor and colleagues examined the potential effect of troxerutin on anxiety-and depressive-like behaviors in the offspring of HFD fed dams [58]. HFD offspring demonstrated higher anxiety and depressive-like behaviors, higher blood sugar, cholesterol and cortisol levels compared to the control groups.…”