The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs

Hussain, Zahid; Jung, Da Hyun; Lee, Young Ju; Park, Hyojin

doi:10.5056/jnm18049

Cited by 13 publications

(13 citation statements)

References 40 publications

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“…They also found that trimebutine significantly regulated gastrointestinal motility by promoting gastric emptying as well as reducing bowel movements. 62 It is reasonable to speculate the mechanism of trimebutine may be relevant to inhibition of CRF.…”

Section: The Role Of Gastrointestinal Infection In the Pathogenesis Of Irritable Bowel Syndrome Functional Dyspepsia And Overlap Syndromementioning

confidence: 99%

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Wang

Fang

2021

J Neurogastroenterol Motil

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Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious inflammation and local or systemic immune response play significant roles. There are few studies focusing on the mechanism of inflammation in patients with overlap syndrome of irritable bowel syndrome and functional dyspepsia (IBS-FD). This review focuses on current advances about the role of inflammation in the pathogenesis of IBS and FD and the possible mechanism of inflammation in IBS-FD.

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Section: The Role Of Gastrointestinal Infection In the Pathogenesis Of Irritable Bowel Syndrome Functional Dyspepsia And Overlap Syndromementioning

confidence: 99%

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Wang

Fang

2021

J Neurogastroenterol Motil

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“…Regarding preclinical studies, TM was recently shown to be effective at maintaining upper and lower GI motor function in a peripheral CRF overlapping model with guinea pigs [ 33 ]. It is worth noting that apart from GI tract motility disorders, recent data suggest that TM may exert antitumor activities against gut and brain malignancies [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Trimebutine Maleate Monotherapy for Functional Dyspepsia: A Multicenter, Randomized, Double-Blind Placebo Controlled Prospective Trial

et al. 2020

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Background and Objectives: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders; it has a great impact on patient quality of life and is difficult to treat satisfactorily. This study evaluates the efficacy and safety of trimebutine maleate (TM) in patients with FD. Materials and Methods: Α multicenter, randomized, double-blind, placebo controlled, prospective study was conducted, including 211 patients with FD. Participants were randomized to receive TM 300 mg twice per day (BID, 108 patients) or placebo BID (103 patients) for 4 weeks. The Glasgow Dyspepsia Severity Score (GDSS) was used to evaluate the relief of dyspepsia symptoms. Moreover, as a pilot secondary endpoint, a substudy (eight participants on TM and eight on placebo) was conducted in to evaluate gastric emptying (GE), estimated using a 99mTc-Tin Colloid Semi Solid Meal Scintigraphy test. Results: Of the 211 patients enrolled, 185 (87.7%) (97 (52.4%) in the TM group and 88 (47.6%) in the placebo group) completed the study and were analyzed. The groups did not differ in their demographic and medical history data. Regarding symptom relief, being the primary endpoint, a statistically significant reduction in GDSS for the TM group was revealed between the first (2-week) and final (4-week) visit (p-value = 0.02). The 99 mTc-Tin Colloid Semi Solid Meal Scintigraphy testing showed that TM significantly accelerated GE obtained at 50 min (median emptying 75.5% in the TM group vs. 66.6% in the placebo group, p = 0.036). Adverse effects of low to moderate severity were reported in 12.3% of the patients on TM. Conclusion: TM monotherapy appears to be an effective and safe approach to treating FD, although the findings presented here warrant further confirmation.

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“…The guinea pig is a good model to study intestinal motility and the enteric nervous system. The models used are similar to what we previously described in rodents, with the use of stress models such as water avoidance and CRH injection ( 269 , 270 ). As a model of altered GI transit, several chemical approaches have been used in guinea pigs such as the gavage with mustard oil and serotonin or the injection of TRH.…”

Section: Non-rodent Modelsmentioning

confidence: 99%

Animal Models for Functional Gastrointestinal Disorders

Accarie

Vanuytsel

2020

Front. Psychiatry

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Functional gastrointestinal disorders (FGID), such as functional dyspepsia (FD) and irritable bowel syndrome (IBS) are characterized by chronic abdominal symptoms in the absence of an organic, metabolic or systemic cause that readily explains these complaints. Their pathophysiology is still not fully elucidated and animal models have been of great value to improve the understanding of the complex biological mechanisms. Over the last decades, many animal models have been developed to further unravel FGID pathophysiology and test drug efficacy. In the first part of this review, we focus on stress-related models, starting with the different perinatal stress models, including the stress of the dam, followed by a discussion on neonatal stress such as the maternal separation model. We also describe the most commonly used stress models in adult animals which brought valuable insights on the brain-gut axis in stress-related disorders. In the second part, we focus more on models studying peripheral, i.e., gastrointestinal, mechanisms, either induced by an infection or another inflammatory trigger. In this section, we also introduce more recent models developed around food-related metabolic disorders or food hypersensitivity and allergy. Finally, we introduce models mimicking FGID as a secondary effect of medical interventions and spontaneous models sharing characteristics of GI and anxiety-related disorders. The latter are powerful models for brain-gut axis dysfunction and bring new insights about FGID and their comorbidities such as anxiety and depression.

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The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs

Cited by 13 publications

References 40 publications

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Trimebutine Maleate Monotherapy for Functional Dyspepsia: A Multicenter, Randomized, Double-Blind Placebo Controlled Prospective Trial

Animal Models for Functional Gastrointestinal Disorders

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