The Effect of Trilafon?? On Postanesthetic Nausea, Retching and Vomiting

The Effects of Premedication With Phenothiazine Derivatives on the Course of Methohexitone Anaesthesia

“…However, Lamphier (1959) observed no cardiovascular upset following the intramuscular injection of prochlorperazine 10 mg. Dobkin (1959) found that perphenazine 5 mg had no effect on blood pressure or pulse rate. This is supported by Phillips et al (1958), who found that premedication with perphenazine 5 mg resulted in less hypotension during thiopentone, nitrous oxide and oxygen anaesthesia than did morphine 10 mg. Lear et al (1959) noted a 14.5 per cent incidence of hypotension following intramuscular injection of 10 to 40-mg doses of triflupTomazine and the frequency increased with age and with the addition of pethidine. This was contrary to the experience of Zeedick (1960), who observed no hypotension following the use of 20-mg doses.…”

Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review

“…Following the examination of the full text articles, 12 publications were excluded ( Table 1). [9][10][11][12][13][14][15][16][17][18][19][20] Eleven randomised, controlled trials (six trials in adults and five trials in children), published between 1965 and 1999, were finally included in the review (Tables 2 and 3). 18,[21][22][23][24][25][26][27][28][29][30] The data of 2081 participants (805 patients received perphenazine and 1276 received another drug or placebo as control) could be analysed.…”

“…Reason for exclusion Moore et al 9 No randomisation Scurr and Robbie 10 No randomisation Dobkin 11 No randomisation, case series Robbie 12 No randomisation Lind 13 No randomisation Phillips et al 14 No randomisation Purkis and Ishii 15 No randomisation Zeni 16 Historic control group Dundee et al 17 No randomisation Lind et al 18 No randomisation Dundee et al 19 No randomisation Loewen et al 20 Review Table 2 Characteristics of the included studies testing the efficacy of perphenazine in the prophylaxis of PONV in an adult population …”

The Cure for Postoperative Vomiting

“…Favourable reports have appeared on the use of perphenazine (Fentazin) (Scurr and Robbie, 1958;Wang, 1958;Phillips et al, 1960). Prolonged drowsiness and a Parkinsonian-type reaction may result from large doses, but the drug is sufficiently effective to make these doses unnecessary in general use.…”