The Effect of Triiodothyronine in Healing of Deep Dermal Burns and Marginal Scars of Skin grafts. A Histologic Study

Mehregan, Amir H.; Zamick, Paul

doi:10.1111/j.1600-0560.1974.tb00201.x

Cited by 24 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent findings have shown that hypothyroidism in mice retards wound healing relative to euthyroidism (Safer et al, 2004;Safer et al, 2005). In contrast, prior reports examining the effects of THs on wound healing have been contradictory, even when THs were administered similarly (Lennox and Johnston, 1973;Zamick and Mehregan, 1973;Mehregan and Zamick, 1974;Erdogan et al, 1999). Ambiguities have also resulted from studies on keratin expression.…”

Section: Function Of Ths In Development and Homeostasismentioning

confidence: 74%

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

Kress

Samarut

Plateroti

2009

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Thyroid hormones and the control of cell proliferation or cell differentiation: paradox or duality?. Molecular and Cellular Endocrinology, Elsevier, 2009, 313 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. SummaryAmphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control diverse cellular processes depending on the tissue context. This point is also reinforced by a recent accumulation of evidence. For example, thyroid hormones and their nuclear receptor TRs have been described to function in different systems in synergy and/or in antagonism with other signaling pathways. This interaction helps explain their pleiotropic roles. This review summarizes the most important advances in this field, focusing in particular on the key action of thyroid hormones in controlling the balance between the processes of cell proliferation and cell differentiation in a few organs, with special attention paid to the intestine. We highlight similarities between the cellular and molecular events occurring during postnatal intestinal maturation at metamorphosis in amphibians, and comparable events observed at weaning in mice. 1-Introduction1.1 Thyroid hormone production Thyroid hormones (THs), L-thyroxine or T4 and 3,5,3'-L-triiodothyronine or T3, are essential for the development of several organs, including the central nervous system, skeleton, heart, intestine, skeletal muscle and sensory organs. Moreover, they also have important regulatory effects on oxygen consumption and metabolic rate (Oppenheimer et al., 1987). The follicular cells of the thyroid gland synthesize and secrete both hormones, but T4 is the most abundant. This process is under the control of circulating THs levels through the hypothalamuspituitary-thyroid feedback regulatory loop (rev. in Fredric and Wondisford, 2004). The intracellular concentration of T3 is dependent upon the uptake of T3 and T4, and their subsequent metabolism (Bianco and Kim, 2006). In fact, both hormones are actively transported across the cell membrane by specific transporter proteins, of which monocarboxylate transporter-8 is the best characterized (Dumitrescu et al., 2004;Friesema et al., 2004; rev. in Refetoff andDumitrescu, 2007 andVisser et al., 2007). Three iodothyronine deiodinase selenoenzymes (D1, D2 and D3) regulate TH activation and catabolism (Bianco and Kim, 2006). D1 and D2 catalyze the 5'-deiodination of T4 to its active metabolite T3. T3 is generated from the activity of D1, which is the main source of circulating T3. In contrast, D2 is the isoenzyme primarily responsible for local production of T3 in target cells. T3 derived from ...

show abstract

Section: Function Of Ths In Development and Homeostasismentioning

confidence: 74%

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

Kress

Samarut

Plateroti

2009

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

show abstract

“…T 3 is one of the most potent stimulators of growth, metabolic rate with a potential role for wound healing and also enhances recovery from stress 3 . It was also shown to heal deep dermal burns by improving the organization of collagen bundles and smoothen the scars 11 . The normal serum level of T 3 is approximately 1.5-3.1 nmol/L 5 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a triiodothyronine incorporated nanofibrous biomaterial: its implications on wound healing

Satish

Korrapati

2015

RSC Adv.

View full text Add to dashboard Cite

With rising incidents of non-healing chronic wounds, functional restoration of the organs after a major wound insult is an essential requisite. The delivery of endogenous molecules through nanomaterials for supporting healing of such wounds has gained impetus in the past decade. Triiodothyronine (T 3 ) is a hormone that exerts its activity at various target organs and is reported to play a critical role in repair and regeneration of tissues after injury. The encapsulation of T 3 in nanofibers and its sustained release to enable wound healing has been attempted for the first time in this work. The physico-chemical characterization confirmed the encapsulation and uniform distribution of the hormone in the nanofiber. Functional characterization of the composite nanofibers revealed the significant positive influence of the T 3 -entrapped nanofibers on the proliferation and migration of skin cells. Thus this work reveals the effect of prolonged sustained delivery of T 3 from nanofibers which might promote the healing of chronic wounds.

show abstract

“…An increase in thyroid hormone delivered in drinking water improved the quality of wound healing in euthyroid rats leaving less scar tissue [14,15]. Several reports recommend thyroid therapy for hypothyroid patients undergoing radiation-induced neck fistulae [16-18].…”

mentioning

confidence: 99%

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

et al. 2012

View full text Add to dashboard Cite

Many research studies report the healing effects of Aloe Vera, thyroid hormone cream and silver sulfadiazine. However, the effects of these therapeutic agents are not well understood and have not been compared in one study. This study aimed at investigating the effects of topical application of an Aloe vera gel, a thyroid hormone cream and a silver sulfadiazine cream on the healing of skin wounds surgically induced in Wistar rats for determining the treatment of choice. In a randomized controlled trial, twelve male rats, aged 120 days and with a mean weight of 250 to 300 g, were divided randomly into 5 groups based on drug treatments: Aloe vera gel (AV), thyroid hormone cream (TC), silver sulfadiazine 1% (S), vehicle (V) and control. To evaluate the efficacy of each treatment technique, a biomechanical approach was used to assess tensile stress after 14 days of treatment. Tensile stress was significantly improved in the Aloe vera gel group as compared with the other four groups (P≤0.05). While the other treatment options resulted in better healing than the control group, this difference was not significant. We conclude that Aloe vera topical application accelerated the healing process more than thyroid hormone, silver sulfadiazine and vehicle in surgically induced incisions in rats.

show abstract

The Effect of Triiodothyronine in Healing of Deep Dermal Burns and Marginal Scars of Skin grafts. A Histologic Study

Cited by 24 publications

References 3 publications

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

Fabrication of a triiodothyronine incorporated nanofibrous biomaterial: its implications on wound healing

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

Contact Info

Product

Resources

About