The effect of trematode infection on the markers of oxidative stress in the offspring of the freshwater snail Lymnaea stagnalis

Vorontsova, Yana; Slepneva, Irina A.; Yurlova, Natalia I.; Ponomareva, Natalia M.; Глупов, В. В.

doi:10.1007/s00436-019-06494-5

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…The majority of invertebrate species have shown an immune response that can inactivate and eliminate penetrating parasites, especially those involving the formation of reactive oxygen species (ROS) [38]. ROS is a key trigger of the inflammatory activation of macrophages in malaria and can damage proteins, carbohydrates, and DNA, which are detrimental to parasites [39].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process

Fan

et al. 2020

Korean J Parasitol

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Cystic echinococcosis (CE) is a zoonotic infection caused by Echinococcus granulosus larvae. It seriously affects the development of animal husbandry and endangers human health. Due to a poor understanding of the cystic fluid formation pathway, there is currently a lack of innovative methods for the prevention and treatment of CE. In this study, the protoscoleces (PSCs) in the encystation process were analyzed by high-throughput RNA sequencing. A total of 32,401 transcripts and 14,903 cDNAs revealed numbers of new genes and transcripts, stage-specific genes, and differently expressed genes. Genes encoding proteins involved in signaling pathways, such as putative G-protein coupled receptor, tyrosine kinases, and serine/threonine protein kinase, were predominantly up-regulated during the encystation process. Antioxidant enzymes included cytochrome c oxidase, thioredoxin glutathione, and glutathione peroxidase were a high expression level. Intriguingly, KEGG enrichment suggested that differentially up-regulated genes involved in the vasopressin-regulated water reabsorption metabolic pathway may play important roles in the transport of proteins, carbohydrates, and other substances. These results provide valuable information on the mechanism of cystic fluid production during the encystation process, and provide a basis for further studies on the molecular mechanisms of growth and development of PSCs.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process

Fan

et al. 2020

Korean J Parasitol

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“…The vast majority of invertebrate species have shown an immune response that can inactivate and eliminate penetrating parasites, especially involves the formation of reactive oxygen species (ROS) [42]. ROS is a key trigger of the inflammatory activation of macrophages in malaria, simultaneously, it can damage proteins, carbohydrates, and DNA, which is harmful to the survival of parasites [43].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of the Echinococcus granulosus protoscolex in the encystation process

Fan¹,

Wu²,

Li³

et al. 2020

Preprint

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Back ground: Echinococcosis (CE) is a zoonosis and in humans it occurs as a result of infection by the larva of Echinococcus granulosus . CE is seriously affects the development of animal husbandry and endangers human health. Due to the lack of in-depth understanding of the cystic fluid formation pathway, prevention and treatment of CE have been lack of innovative methods. Result: High throughput RNA-sequencing (RNA-seq) of protoscoleces (PSCs) in the encystation process of total three biological replicates for each period on 0d, 10d, 20d, 40d and 80d were analyzed. The results demonstrated, a total of 32,401 transcripts and 14,903 genes, including numbers new genes, new transcript, stage-specific genes and differently expression genes (DEGs). Genes encoding proteins involved in several signaling pathways, such as putative G-protein coupled receptor (GPCR), tyrosine kinases and serine/threonine protein kinase were predominantly up-regulated during encystation process of PSCs. Moreover, three major antioxidant proteins of PSCs were identified, and these proteins demonstrated have a high expression level, including cytochrome c oxidase, thioredoxin glutathione, and glutathione peroxidase. Intriguingly, The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested that up-regulated DEGs involved in the vasopressin-regulated water reabsorption metabolic pathway might play important roles in the protein, carbohydrate, and other substances transport. Conclusions: The present study carried out the transcriptomic analysis of the encystation process of E. granulosus PCSs, which provide valuable information for the mechanism of cystic fluid formation during the encystation process. These results provide a basis and reference for further studies for investigation of the molecular mechanisms involved in PSC growth and development. Keywords: Echinococcus granulosus , Encystation process, Differentially expressed genes, Protoscolex, RNA-seq

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Biology of the Lymnaeidae–Parasite Interaction

Alba,

Gourbal

2023

Zoological Monographs

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The effect of trematode infection on the markers of oxidative stress in the offspring of the freshwater snail Lymnaea stagnalis

Cited by 5 publications

References 16 publications

Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process

Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process

Transcriptomic analysis of the Echinococcus granulosus protoscolex in the encystation process

Biology of the Lymnaeidae–Parasite Interaction

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