The effect of treatment with growth hormone on fertility outcome in eugonadal women with growth hormone deficiency: report of four cases and review of the literature

Successful pregnancy and delivery in a patient with adult GH deficiency: role of GH replacement therapy

“…Spiliotis BE suggested GH/IGF-I influences the pituitary and gonadal functions causing problems in the reproductive ability [3]. Giampietro A, et al mentioned the important roles of GH and IGF-I regulations on oocyte fertilization in the early stage of the pregnancy [5]. These reports suggest that regular GH injection in our patient improved oocyte fertilization resulting in pregnancy.…”

“…To our knowledge, there are no other reports of a Japanese patient becoming pregnant during GH replacement therapy, and few cases have been reported in other countries [3][4][5]. Wirén L, et al reported 12 pregnancies in 8 female patients with hypopituitarism.…”

Use of growth hormone in co-treatment with GnRH agonist long protocol in patients 40 years improves embryo quality?

“…An increase patients's number older age who search assisted reproduction treatment is currently observed, biological age ovaries is more important than chronological age patient and can predict the outcome of assisted reproduction treatment (Alviggi et al, 2009). There are only a few reports where adjuvant growth and obtained as a result of an increase in pregnancy rate (Giampietro et al, 2009). Literature reports that treatment with GH may increase the risk of glucose intolerance and the potential for pituitary/hypothalamic tumor recurrence cancer.…”

Pregnancy and pituitary disorders

“…It becomes less important in the later stages of pregnancy because there is a progressive rise of GH after the 20th week of pregnancy with decrement in pituitary GH in maternal serum (47). GH was suggested to improve gonadotropin hormonal action in follicular development, which could be necessary in eugonadal patients with GH deficiency (273). Gestational GH therapy in the first two trimesters of pregnancy was reported to be safe for the mother and the fetus without important adverse events and obstetric complications (274).…”

“…There are case reports of women treated for HH or GH deficiency in eugonadism resulting in successful pregnancies (273,292,293).…”