The Effect of Treatment on the Vascular Component of the Psoriatic Lesion

Lawler, James C.

doi:10.1001/archderm.1960.01580020032004

Cited by 28 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, dilation of these abnormal capillaries was observed prior to keratinocyte hyperplasia in the early development of psoriasis lesions. Notably, the convoluted capillaries remained apparent in the upper dermis for many months even after cutaneous lesions had completely resolved [21], [22].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis and Hypertension Severity: Results from a Case-Control Study

et al. 2011

View full text Add to dashboard Cite

BackgroundEpidemiologic studies have provided new insights into the association between psoriasis and cardiovascular diseases. Previous population studies have examined hypertension frequency in psoriasis patients. However, the relationship between severity of hypertension and psoriasis has not been characterized.ObjectiveWe sought to investigate whether patients with psoriasis have more difficult-to-manage hypertension compared to non-psoriatic hypertensive patients.ApproachWe performed a case-control study using the University of California Davis electronic medical records. The cases were defined as patients diagnosed with both psoriasis and hypertension, and controls were defined as patients with hypertension and without psoriasis. In this identified population, 835 cases were matched on age, sex, and body mass index (BMI) to 2418 control patients.Key ResultsTreatment with multiple anti-hypertensives was significantly associated with the presence of psoriasis using univariate (p<0.0001) and multivariable analysis, after adjusting for diabetes, hyperlipidemia, and race (p<0.0001). Compared to hypertensive patients without psoriasis, psoriasis patients with hypertension were 5 times more likely to be on a monotherapy antihypertensive regimen (95% CI 3.607.05), 9.5 times more likely to be on dual antihypertensive therapy (95% CI 6.68–13.65), 16.5 times more likely to be on triple antihypertensive regimen (95% CI 11.01–24.84), and 19.9 times more likely to be on quadruple therapy or centrally-acting agent (95% CI 10.58–37.33) in multivariable analysis after adjusting for traditional cardiac risk factors.ConclusionsPsoriasis patients appear to have more difficult-to-control hypertension compared to non-psoriatic, hypertensive patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Psoriasis and Hypertension Severity: Results from a Case-Control Study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In a double-blind trial, 21 patients with severe plaque psoriasis were randomly assigned to receive oral cyclosporine, 14 mg/kg/d, or its vehicle. After four weeks of therapy the 11 cyclosporine recipients had the following response to treatment: two had total clearing and six improved markedly, two moderately, and one minimally; whereas ten vehicle-treated patients showed no change or minimal improvement.…”

mentioning

confidence: 99%

Cyclosporine Improves Psoriasis in a Double-blind Study

Ellis¹

1986

JAMA

453

126

View full text Add to dashboard Cite

In a double-blind trial, 21 patients with severe plaque psoriasis were randomly assigned to receive oral cyclosporine, 14 mg/kg/d, or its vehicle. After four weeks of therapy the 11 cyclosporine recipients had the following response to treatment: two had total clearing and six improved markedly, two moderately, and one minimally; whereas ten vehicle-treated patients showed no change or minimal improvement. Vehicle-treated patients, after a switch to cyclosporine for four weeks, demonstrated impressive improvement similar to that seen in patients who initially received only cyclosporine. Moderate or marked improvement or total clearing was noted in 17 (81%) of 21 and 20 (95%) of 21 after one and four weeks of therapy, respectively. Mitotic figures and leukotriene B4 levels in lesions decreased 86% and 64%, respectively, after seven days of cyclosporine therapy. Mononuclear (including activated T cells) and polymorphonuclear leukocyte infiltrates were markedly reduced in lesions of all patients after seven days of cyclosporine therapy. These results suggest that psoriasis may have an immunologic basis mediated by activated T cells and/or other immune cells; if a long-term regimen with a favorable efficacy-side effect ratio can be determined, cyclosporine would be a significant advance in the treatment of psoriasis.

show abstract

“…Abnormal capillary formation not only antidates the development of frank psoriasis [15] but persists for varying periods after the psoriasis has resolved and the skin has apparently returned to normal [13]. Similar histopathological changes are also found persisting after UV light irradiation [11], Spectrophotometric measurements of the colour of post-psoriatic skin differ from the normal pattern and persist for many weeks after clinical resolution of the lesion.…”

Section: Discussionmentioning

confidence: 95%

Skin Colour Changes in Psoriasis. Effect of UV Light Irradiation

Tring

1973

Dermatology

View full text Add to dashboard Cite

The change in colour of clinically unaffected psoriatic skin resolving concomitantly with distant sites of UV-irradiated psoriatic lesions was measured by a spectrophotometer. Skin colour was compared between psoriasis and an area of unaffected skin on a limb protected from UV light while the rest of the body received conventional treatment with UV light. Initially, there was a rapid loss of hue (represented by a flattening of the spectrophotometric curve) while unaffected skin showed elevated measurements which persisted during the course of treatment and subsided slowly for up to 2 weeks after cessation of UV light treatment. Clinically undetectable psoriatic lesions showed persistently raised spectrophotometric measurements for up to 10 weeks after cessation of treatment. This report suggests that a systemic factor stimulated or released by whole body UV light irradiation concomitantly influences the resolution of psoriatic lesions protected from the local effects of UV light.

show abstract

The Effect of Treatment on the Vascular Component of the Psoriatic Lesion

Cited by 28 publications

References 9 publications

Psoriasis and Hypertension Severity: Results from a Case-Control Study

Psoriasis and Hypertension Severity: Results from a Case-Control Study

Cyclosporine Improves Psoriasis in a Double-blind Study

Skin Colour Changes in Psoriasis. Effect of UV Light Irradiation

Contact Info

Product

Resources

About