The effect of treatment of Type 2 (insulin independent) diabetes mellitus on plasma concentrations of pancreatic polypeptide and glucagon

Berger, David Kenneth; Floyd, John C.; Pek, Sumer

doi:10.1007/bf00251278

Cited by 13 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in accordance with the finding that normalisation of fasting plasma glucose by short-term treatment with diet plus insulin is associated with decreases in basal and stimulated secretory activity of the pancreatic polypeptide cells in type 2 diabetes (Berger et al, 1981). Thus, the decrease of PP in our study may be caused by a decrease in fasting plasma glucose.…”

Section: Discussionsupporting

confidence: 94%

Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes

Kahleová

Mari

Nofrate

et al. 2012

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 94%

Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes

Kahleová

Mari

Nofrate

et al. 2012

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

“…Amino acids themselves stimulate protein synthesis and high glucagon attenuates this effect (38). The present data are in agreement with previous findings that showed that normalization of hyperglycemia in people with type 2 diabetes with prolonged insulin treatment is associated with decreases in basal glucagon concentrations and in oral protein stimulated glucagon response (35). A smaller glucagon response in insulin‐treated subjects also suggests that the glucagon sensitivity to protein was improved.…”

Section: Discussionsupporting

confidence: 94%

“…Inappropriate hyperglucagonemia in response to glucose and protein is recognized as a common feature that unfavorably influences diabetes control (34). Glucagon is normally suppressed by hyperglycemia (35). The lack of glucagon suppression by hyperglycemia in diabetes has been explained by a relative deficiency of glucose within the alpha cells, secondary to insulin deficiency, which is restored by insulin infusion (36), a potent inhibitor of glucagon secretion.…”

Section: Discussionmentioning

confidence: 99%

Effect of Insulin and Energy Restriction on the Thermic Effect of Protein in Type 2 Diabetes Mellitus

Gougeon

2001

Obesity Research

View full text Add to dashboard Cite

GOUGEON, RÉ JEANNE. Effect of insulin and energy restriction on the thermic effect of protein in type 2 diabetes mellitus. Obes Res. 2001;9:241-250. Objective: The objective of this study was to test whether the thermic effect of oral protein is blunted in poorly controlled type 2 diabetes and is corrected by normalization of glycemia with insulin and 28 days of a very-lowenergy diet. Research Methods and Procedures:Resting energy expenditure (REE) and the thermic effect of 90 g of oral protein were measured, using indirect calorimetry, in nine (five women and four men) obese diabetic people [weight, 108 Ϯ 10 kg; waist circumference, 123 Ϯ 8 cm; body mass index, 40 Ϯ 3 kg/m 2 ] who were hyperglycemic on day 8 or euglycemic with insulin on day 16 of a weight-maintaining diet and euglycemic on day 28 of a very low energy diet (VLED). Results were compared with those of seven (six women and one man) weight-and body mass indexmatched obese nondiabetic subjects with a waist circumference of 111 Ϯ 6 cm. Substrates and hormonal responses were determined concurrently. Results: Fasting glucose was normalized in the diabetic subjects with insulin from day 9 of VLED onward. Weight decreased in both groups by 9.9 Ϯ 0.9 kg with VLED. REE was 8 Ϯ 2% lower with insulin treatment and decreased by another 14 Ϯ 3% with VLED in the diabetic and by 15 Ϯ 1% in the nondiabetic subjects by week 4. After the protein meal, the thermic response was significantly (p Ͻ 0.05) less with hyperglycemia than with insulin-induced euglycemia, as percentage above REE (15.3 Ϯ 1.4 compared with 21.2 Ϯ 1.5%), as percentage of the energy content of the meal (19.5 Ϯ 1.5 compared with 25.2 Ϯ 1.7%), as kilocalories per 405 minutes (86 Ϯ 5 compared with 110 Ϯ 7), and less than in nondiabetic obese controls (21.0 Ϯ 2.2% above REE, 24.4 Ϯ 1.7% of energy of meal). After the VLED, the thermic effect of protein was significantly higher in both groups only as percentage above REE. The initial glucagon response was greater with hyperglycemia compared with euglycemia and post-VLED but not compared with the nondiabetic subjects. Hyperglycemia was associated with 21 Ϯ 4% greater urinary urea nitrogen excretion and urinary glucose losses of 134 Ϯ 50 mmol/d. Discussion: This study shows a blunted thermic effect of protein in obese hyperglycemic type 2 diabetic subjects compared with matched nondiabetic subjects that can be corrected with insulin-or energy restriction-induced euglycemia.

show abstract

“…It has been reported that plasma pancreatic poly¬ peptide (PP) levels in diabetic subjects increases not only at the fasting state (Bergen et al 1981;Floyd et al 1977;Mizuno et al 1979), but also during the diabetic ketoacidosis (Skare et al 1980) or after ingestion of beef or a test meal (Bergen et al 1981;Floyd et al 1977;Ishida et al 1981). Morphologicallv the PP cells in the islets of the juvenile diabetic pancreas show hyperfunctioning activity (Gepts et al 1977).…”

mentioning

confidence: 97%

Plasma responses of pancreatic polypeptide, glucagon and insulin in normal and alloxan diabetic dogs, and their regional levels in the pancreas

Tasaka¹,

Inoue

Marumo

et al. 1984

Acta Endocrinologica

View full text Add to dashboard Cite

The plasma responses of pancreatic polypeptide (PP), glucagon (IRG) and insulin (IRI) after administration of beef soup were studied in normal and alloxan diabetic dogs kept in a poor metabolic state for 4 weeks, and their regional levels in the pancreas were determined and compared at the uncinate process, head, body and tail. The plasma PP levels of the diabetic dogs were significantly higher than those of the normal dogs and they increased after beef soup administration in both groups. The plasma IRG levels did not change significantly after beef soup administration in either group, but significantly high levels were found in the diabetic dogs. The IRI content in the normal dog pancreas was highest at the tail, followed in order by the body, head and uncinate process, and was decreased to about one-tenth to one-fortieth in the alloxan diabetic dogs. On the other hand, the amounts of PP in the pancreas of both normal and diabetic dogs were greatest at the uncinate process, followed in order by the head, body and tail. In an inverse relationship with the PP findings, the IRG content in the pancreas was highest at the tail and lowest at the uncinate process in both kinds of dogs. The differences in both PP and IRG between diabetic and normal dogs were generally not significant. These results show that irrespective of the high plasma levels of PP and IRG in the diabetic dogs, their levels in the pancreas did not change significantly.

show abstract

The effect of treatment of Type 2 (insulin independent) diabetes mellitus on plasma concentrations of pancreatic polypeptide and glucagon

Cited by 13 publications

References 17 publications

Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes

Improvement in β-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes

Effect of Insulin and Energy Restriction on the Thermic Effect of Protein in Type 2 Diabetes Mellitus

Plasma responses of pancreatic polypeptide, glucagon and insulin in normal and alloxan diabetic dogs, and their regional levels in the pancreas

Contact Info

Product

Resources

About