The Effect of Treatment History on Therapeutic Outcome: An Experimental Approach

Kessner, Simon S; Wiech, Katja; Forkmann, Katarina; Ploner, Markus; Bingel, Ulrike

doi:10.1001/jamainternmed.2013.6705

Cited by 85 publications

(73 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have recently shown that treatment experiences not only modulate the future response to the same treatment approach, but can substantially modify the response to a different subsequent treatment approach 15 . Findings of our current study suggest that this impact of prior treatment experiences might be enhanced in children and impacts on the response to subsequent treatment.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Are Children the Better Placebo Analgesia Responders? An Experimental Approach

Wrobel

Fadai

Sprenger

et al. 2015

The Journal of Pain

Self Cite

View full text Add to dashboard Cite

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Are Children the Better Placebo Analgesia Responders? An Experimental Approach

Wrobel

Fadai

Sprenger

et al. 2015

The Journal of Pain

Self Cite

View full text Add to dashboard Cite

“…This might make them more resistant to expectation interventions. 23,41 On the other hand, patients are likely to have a higher desire for pain relief, possibly making them more sensitive to expectation interventions. 24,38,70,82 Three common, brief, and easy-to-implement interventions that have been found to induce and/or enhance expectations are promising for implementation in clinical practice: verbal suggestion, conditioning, and imagery.…”

Section: Introductionmentioning

confidence: 99%

Relieving patients' pain with expectation interventions

Peerdeman

Laarhoven

Keij

et al. 2016

Pain

185

156

View full text Add to dashboard Cite

Patients' expectations are important predictors of the outcome of analgesic treatments, as demonstrated predominantly in research on placebo effects. Three commonly investigated interventions that have been found to induce expectations (verbal suggestion, conditioning, and mental imagery) entail promising, brief, and easy-to-implement adjunctive procedures for optimizing the effectiveness of analgesic treatments. However, evidence for their efficacy stems mostly from research on experimentally evoked pain in healthy samples, and these findings might not be directly transferable to clinical populations. The current meta-analysis investigated the effects of these expectation inductions on patients' pain relief. Five bibliographic databases were systematically searched for studies that assessed the effects of brief verbal suggestion, conditioning, or imagery interventions on pain in clinical populations, with patients experiencing experimental, acute procedural, or chronic pain, compared with no treatment or control treatment. Of the 15,955 studies retrieved, 30 met the inclusion criteria, of which 27 provided sufficient data for quantitative analyses. Overall, a medium-sized effect of the interventions on patients' pain relief was observed (Hedges g = 0.61, I = 73%), with varying effects of verbal suggestion (k = 18, g = 0.75), conditioning (always paired with verbal suggestion, k = 3, g = 0.65), and imagery (k = 6, g = 0.27). Subset analyses indicated medium to large effects on experimental and acute procedural pain and small effects on chronic pain. In conclusion, patients' pain can be relieved with expectation interventions; particularly, verbal suggestion for acute procedural pain was found to be effective.

show abstract

“…Moreover, receiving a placebo after simulating an effective analgesic treatment compared to receiving the same placebo intervention after a treatment perceived as ineffective produce a 49.3% versus 9.7% placebo induced pain reduction, respectively (10). The relationship between prior either unsuccessful or successful pain relief interventions and placebo analgesic effects is linked to a higher activation of the bilateral posterior insulae, and reduced activation of the right dorsolateral prefrontal cortex (11). …”

mentioning

confidence: 99%