The effect of travoprost on daytime intraocular pressure in normal tension glaucoma: a randomised controlled trial

Abstract

Travoprost monotherapy had a sustained hypotensive effect in NTG and achieved a reasonable or good response (>20% reduction in average IOP) in 32.9% of treated eyes. However, in the majority of eyes with NTG, travoprost monotherapy appeared unable to produce the desirable 30% reduction in average IOP.

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

“…10,13,20,21 Travoprost 0.004% has been reported to have similar results (16.7% to 25.1%). 17,18 Our results are in accordance with the results of these previous studies.…”

“…Ang et al 18 published the only report showing the effect of travoprost on daytime IOP in NTG. These authors reported a mean IOP reduction of 16.1%, a maximum IOP reduction of 13.5%, a 43% rate of .20% IOP reduction, and a 30% rate of ,10% IOP reduction (considered as TNR) in both mean and maximum IOP.…”

“…Almost all of our data were obtained within a one-to twomonth period after the beginning of travoprost treatment, whereas the data from the study by Ang et al were obtained at six months. 18 Achievement of an IOP reduction greater than 30% as recommended by the CNTG study group is very difficult using a single, topical antiglaucoma eye drop. [10][11][12][13]17,18,20,21 In our study, the rates of 30% IOP reduction are 23.5% for maximum 24-hour IOP and 11.8% for mean 24-hour IOP.…”

“…18 Achievement of an IOP reduction greater than 30% as recommended by the CNTG study group is very difficult using a single, topical antiglaucoma eye drop. [10][11][12][13]17,18,20,21 In our study, the rates of 30% IOP reduction are 23.5% for maximum 24-hour IOP and 11.8% for mean 24-hour IOP. When a topical combination therapy is needed to achieve the target reduction in IOP, travoprost without BAK is a superior option because preservatives such as BAK can induce conjunctival inflammation and affect success rates for filtering surgery.…”

“…9,[14][15][16] However, only two reports have investigated the effect of travoprost on NTG. 17,18 Suh et al 17 reported the effect of travoprost on clinic IOP measurements in patients with NTG over a 12-month period, and Ang et al 18 reported the effect of travoprost on daytime IOP in NTG patients. Neither group measured changes in IOP overnight in NTG patients.…”