The Effect of Transforming Growth Factor β1 on Mesangial Cell Fibronectin Synthesis: Increased Incorporation into the Extracellular Matrix and Reduced pI but No Effect on Alternative Splicing

McKay, Neil G.; Khong, Tee Fern; Haites, Neva Elizabeth; Power, David A.

doi:10.1006/exmp.1993.1040

Cited by 33 publications

(15 citation statements)

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“…A modification in the pattern of IIICS Fn splicing induced by TGF-β has been reported in certain malignant cell lines [15], whilst in mesangial cells no alteration has been observed [31]. In our study, TGF-β seemed not to change the pattern of IIICS mRNA variants as shown by electrophoresis of RT-PCR products.…”

Section: Discussioncontrasting

confidence: 45%

Modulation of human bronchial epithelial cell IIICS fibronectin mRNA in vitro

Rosi¹,

Beckmann²,

Pladsen³

et al. 1996

Eur Respir J

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Section: Discussioncontrasting

confidence: 45%

Modulation of human bronchial epithelial cell IIICS fibronectin mRNA in vitro

Rosi¹,

Beckmann²,

Pladsen³

et al. 1996

Eur Respir J

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“…TGF-␤1 also inhibits plasminogen activator production while stimulating plasminogen activator inhibitor synthesis by normal rat glomeruli (99). In various assays examining cultured human mesangial cells or isolated perfused kidneys, TGF-␤1 stimulates expression of types I, -III, and -IV collagen, laminin, fibronectin, and heparan sulfate proteoglycans (21,27,63,80).…”

Section: Tgf-␤-stimulated Ecm Collagen Productionmentioning

confidence: 99%

TGF-β signal transduction and mesangial cell fibrogenesis

Schnaper

Hayashida

Hubchak

et al. 2003

American Journal of Physiology-Renal Physiology

296

211

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Transforming growth factor-β (TGF-β) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways that are activated by TGF-β. This knowledge is being applied to glomerular mesangial cell models of extracellular matrix (ECM) accumulation. A central component of TGF-β-stimulated mesangial cell fibrogenesis is the TGF-β family-specific Smad signal transduction pathway. However, while Smads play an important role in collagen accumulation, recent findings indicate that cross talk among a variety of pathways is necessary for maximal stimulation of collagen expression. Further investigation of these multiple interactions will provide insight into possible ways to interrupt cellular mechanisms of glomerular fibrogenesis.

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“…Several studies have demonstrated that TGF-ß stimulates the mRNA and protein for various extracellular matrix proteins in glomerular cells [5][6][7][8]. The major matrix proteins stimulated by TGF-ß include types I and III collagen, fibronectin and various proteoglycans [5][6][7][8].…”

Section: Tgf-ß Favors Extracellular Matrix Accumulation In Vitromentioning

confidence: 99%

TGF-β in Glomerular Disease

Shankland

Johnson

1998

Mineral Electrolyte Metab

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Transforming growth factor-β (TGF-β) is an important cytokine in glomerular disease. Its major role may be to mediate extracellular matrix deposition, by both increasing the synthesis of matrix components and by reducing their degradation. Strong evidence supports the functional role for TGF-β in mesangial matrix expansion. However, TGF-β may also have other important functions in the glomerulus, including the regulation of cell proliferation, hypertrophy, and survival (apoptosis), as well as modulation of the local and systemic immune response.

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The Effect of Transforming Growth Factor β1 on Mesangial Cell Fibronectin Synthesis: Increased Incorporation into the Extracellular Matrix and Reduced pI but No Effect on Alternative Splicing

Cited by 33 publications

References 0 publications

Modulation of human bronchial epithelial cell IIICS fibronectin mRNA in vitro

Modulation of human bronchial epithelial cell IIICS fibronectin mRNA in vitro

TGF-β signal transduction and mesangial cell fibrogenesis

TGF-β in Glomerular Disease

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