The effect of transcranial direct current stimulation on cognitive performance in youth with persistent cognitive symptoms following concussion: a controlled pilot study

Launay, Keelia Quinn de; Cheung, Stephanie; Riggs, Lily; Reed, Nick; Beal, Deryk S.

doi:10.1080/02699052.2022.2034179

Cited by 6 publications

(6 citation statements)

References 78 publications

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“…Both cognitive behavioral treatment and melatonin have been shown effective for sleep disturbance in pediatric PPCS, but did not help in behavior or cognition 38 , 39 . Perceptual cognitive training did not show any benefit 40 and transcranial direct current stimulation has yet to show positive effects 41 . Collaborative care intervention, including cognitive behavioral treatment, medications and care management, have shown to reduce PPCS symptoms with a small effect size 42 .…”

Section: Discussionmentioning

confidence: 90%

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial

Hadanny

Catalogna

Yaniv

et al. 2022

Sci Rep

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Persistent post-concussion syndrome (PPCS) is a common and significant morbidity among children following traumatic brain injury (TBI) and the evidence for effective PPCS treatments remains limited. Recent studies have shown the beneficial effects of hyperbaric oxygen therapy (HBOT) in PPCS adult patients. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on children (age 8–15) suffering from PPCS from mild-moderate TBI events six months to 10 years prior. Twenty-five children were randomized to receive 60 daily sessions of HBOT (n = 15) or sham (n = 10) treatments. Following HBOT, there was a significant increase in cognitive function including the general cognitive score (d = 0.598, p = 0.01), memory (d = 0.480, p = 0.02), executive function (d = 0.739, p = 0.003), PPCS symptoms including emotional score (p = 0.04, d = – 0.676), behavioral symptoms including hyperactivity (d = 0.244, p = 0.03), global executive composite score (d = 0.528, p = 0.001), planning/organizing score (d = 1.09, p = 0.007). Clinical outcomes correlated with significant improvements in brain MRI microstructural changes in the insula, supramarginal, lingual, inferior frontal and fusiform gyri. The study suggests that HBOT improves both cognitive and behavioral function, PPCS symptoms, and quality of life in pediatric PPCS patients at the chronic stage, even years after injury. Additional data is needed to optimize the protocol and to characterize the children who can benefit the most.

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Section: Discussionmentioning

confidence: 90%

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial

Hadanny

Catalogna

Yaniv

et al. 2022

Sci Rep

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“…In addition, we performed a citation search and retrieved 15 records from the reference lists of similar reviews. Finally, following the exclusion of records that did not meet our criteria, we included five studies which assessed the effect of tDCS or rTMS on headaches and cognitive and psychological symptoms following a concussion [23,[26][27][28][29]. Table 1 summarizes the extracted data of the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…After conducting a comprehensive literature review, we included a total of five controlled studies: one using tDCS and four using rTMS. The tDCS study focused on cognitive symptoms [26], while the rTMS studies considered a diverse range of symptoms, including depression, headaches, and general manifestations of PPCS development [23,[27][28][29]. The tDCS study and three of the rTMS studies stimulated the left DLPFC, while one rTMS study targeted the left primary motor cortex.…”

Section: Discussionmentioning

confidence: 99%

“…Our literature search retrieved only one double-blind, sham-controlled crossover clinical trial investigating cognitive symptoms. This study evaluated the effectiveness and tolerability of multi-session anodal tDCS in a group of young patients (10 females and 2 males, mean age: 15.9 years) who sustained a concussion at least one month prior to inclusion and experienced PPCS [26]. Three sessions of anodal tDCS were applied to the left DLPFC (20 min at 1.5 mA) and the effects were assessed on working memory using a dual-task paradigm.…”

Section: Cognitive Symptomsmentioning

confidence: 99%

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A Scoping Review on the Use of Non-Invasive Brain Stimulation Techniques for Persistent Post-Concussive Symptoms

Khosravi,

Louras,

Martens

et al. 2024

Biomedicines

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Background: In the context of managing persistent post-concussive symptoms (PPCS), existing treatments like pharmacotherapy, cognitive behavioral therapy, and physical rehabilitation show only moderate effectiveness. The emergence of neuromodulation techniques in PPCS management has led to debates regarding optimal stimulation parameters and their overall efficacy. Methods: this scoping review involved a comprehensive search of PubMed and ScienceDirect databases, focusing on controlled studies examining the therapeutic potential of non-invasive brain stimulation (NIBS) techniques in adults with PPCS. Results: Among the 940 abstracts screened, only five studies, encompassing 103 patients (12 to 29 per study), met the inclusion criteria. These studies assessed the efficacy of transcranial direct current stimulation (tDCS), or repetitive transcranial magnetic stimulation (rTMS), applied to specific brain regions (i.e., the left dorsolateral pre-frontal cortex (DLPFC) or left motor cortex (M1)) for addressing cognitive and psychological symptoms, headaches, and general PPCSs. The results indicated improvements in cognitive functions with tDCS. In contrast, reductions in headache intensity and depression scores were observed with rTMS, while no significant findings were noted for general symptoms with rTMS. Conclusion: although these pilot studies suggest promise for rTMS and tDCS in PPCS management, further research with larger-scale investigations and standardized protocols is imperative to enhance treatment outcomes for PPCS patients.

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“…This difference brings the question of how we can compare the elapsed time after injury in rodent model and human brain pathology. Longterm alterations could be in future treated, as suggest by a recent clinical work proposing to use transcranial direct current stimulation to treat PPCS in children [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

Obenaus

Rodriguez‐Grande

Lee

et al. 2023

acta neuropathol commun

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Traumatic brain injury (TBI) has the highest incidence amongst the pediatric population and its mild severity represents the most frequent cases. Moderate and severe injuries as well as repetitive mild TBI result in lasting morbidity. However, whether a single mild TBI sustained during childhood can produce long-lasting modifications within the brain is still debated. We aimed to assess the consequences of a single juvenile mild TBI (jmTBI) at 12 months post-injury in a mouse model. Non-invasive diffusion tensor imaging (DTI) revealed significant microstructural alterations in the hippocampus and the in the substantia innominata/nucleus basalis (SI/NB), structures known to be involved in spatial learning and memory. DTI changes paralled neuronal loss, increased astrocytic AQP4 and microglial activation in the hippocampus. In contrast, decreased astrocytic AQP4 expression and microglia activation were observed in SI/NB. Spatial learning and memory were impaired and correlated with alterations in DTI-derived derived fractional ansiotropy (FA) and axial diffusivity (AD). This study found that a single juvenile mild TBI leads to significant region-specific DTI microstructural alterations, distant from the site of impact, that correlated with cognitive discriminative novel object testing and spatial memory impairments at 12 months after a single concussive injury. Our findings suggest that exposure to jmTBI leads to a chronic abnormality, which confirms the need for continued monitoring of symptoms and the development of long-term treatment strategies to intervene in children with concussions.

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The effect of transcranial direct current stimulation on cognitive performance in youth with persistent cognitive symptoms following concussion: a controlled pilot study

Cited by 6 publications

References 78 publications

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial

A Scoping Review on the Use of Non-Invasive Brain Stimulation Techniques for Persistent Post-Concussive Symptoms

A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

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