The Effect of Tramadol on the Peristaltic Movement Small Intestine in Rabbit

Abstract

Tramadol is an opium analgesic drug that is used to relieve moderate to relatively severe pain. The major side effect of opium analgesic drugs is inhibit the intestinal peristalsis motility, and the effect of tramadol on gut motility is unknown quitely, therefore the effect of tramadol on intestinal peristalsis in vitro was examined in segments of the rabbit small intestine. Our study demonstrated that the low concentration of tramadol (0.1, 0.2, 0.3 , 0.4 , 0.5) ml , escort to activation peristalsis movement while increase the concentration (0.6, 0.7, 0.8, 0.9, 1.0) ml lead to decrease the contraction but when increase the concentration to 1ml lead to inhibited the peristalsis movement and complete relaxation. There for the study was concluded that the tramadol uses on rabbit small intestine decrease the peristalsis movement and this inhibition depend on concentration manner.