The Effect of 'Training' on the Release of Corticotrophin in Response to Minor Stressful Procedures in the Rat

Hodges, John R.; Mitchley, Susan

doi:10.1677/joe.0.0470253

Cited by 38 publications

(16 citation statements)

References 2 publications

(2 reference statements)

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“…A previous study (Hodges & Sadow, 1969) of the effect of prolonged treatment with cortisol was unsatisfactory both because many animals succumbed to infection and because of the stress associated with injections (Hodges & Mitchley, 1970b).…”

Section: Discussionmentioning

confidence: 99%

Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

Hodges

Mitchley

1970

British J Pharmacology

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Summary1. Betamethasone caused growth retardation, adrenal atrophy and impaired hypothalamo-pituitary-adrenal (HPA) activity in the rat. 2. In spite of the profound impairment, recovery of normal HPA function was rapid, but the growth retardation persisted.3. The ability of the pituitary gland to secrete basal corticotrophin (ACTH), recovered more rapidly and the adrenocorticotrophic response to stress less rapidly than the ability of the adrenal cortex to respond to ACTH. 4. The degree of HPA suppression was not determined by the total dose of steroid. 5. The possible significance of the results is discussed.

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Section: Discussionmentioning

confidence: 99%

Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

Hodges

Mitchley

1970

British J Pharmacology

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“…Animals weighing between 250 and 300 g-were housed four per cage for at least 3 days before each experiment in a room with controlled lighting (lights on 07.00-19.00 hr) in which the temperature was maintained between 21-23 'C. They were handled regularly (Hodges & Mitchley, 1970) and food and water were available ad libitum.…”

Section: Methodsmentioning

confidence: 99%

The influence of vasopressin on hypothalamic corticotrophin releasing activity in rats with inherited diabetes insipidus.

Buckingham¹

1981

The Journal of Physiology

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SUMMARY1. The corticotrophin releasing activity of hypothalamic extracts from rats congenitally lacking vasopressin (Brattleboro strain) has been studied in the presence and absence of arginine vasopressin and its antiserum.2. Hypothalamic extracts from Brattleboro rats stimulated the production of corticotrophin by pituitary segments in vitro but both their potency and the slopes of their dose-response lines were significantly less than those of controls. Arginine vasopressin also stimulated pituitary-adrenocorticotrophic activity in vitro but only in concentrations considerably greater than those present in hypothalamic extracts from normal rats.3. In low, physiological concentrations arginine vasopressin did not affect the corticotrophin releasing activity of hypothalamic extracts from controls but potentiated markedly the activity ofextracts from Brattleboro rats and rendered the slopes of their dose-response lines parallel with those of the controls.4. The antiserum to arginine vasopressin did not affect the corticotrophin releasing activity of Brattleboro extracts but reduced the activity of control extracts and rendered the slopes of their dose-response lines parallel with those of Brattleboro extracts.5. The results suggest that vasopressin acts synergistically with the corticotrophin releasing factor and is essential for the full expression ofpituitary-adrenocorticotrophic activity.

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“…Male albino Sprague-Dawley rats (Charles River, SPF) weighing 75-100 g were housed two per cage for at least 1 week before each experiment in a room in which the temperature was maintained at 22 'C. The animals were handled regularly (Hodges & Mitchley, 1970a) and food and water were available ad libitum.…”

Section: Methodsmentioning

confidence: 99%

The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone

Buckingham

1979

The Journal of Physiology

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SuMAY1. The effects of stress, adrenalectomy and corticosterone treatment on the functional activity of the hypothalamo-pituitary-adrenocortical system have been studied using highly sensitive and precise bio-assay methods for the determination of ACTH and CRH.2. Adrenalectomy resulted in a rise and corticosterone treatment a fall in the hypothalamic CRH content and the plasma ACTH concentration.3. Stress caused a fall followed by a rise in the hypothalamic CRH content, a rise in the pituitary and plasma ACTH concentrations and an increase in the plasma corticosterone concentration.4. The stress-induced changes in hypothalamic CRH content and pituitary and plasma ACTH were exaggerated in adrenalectomized rats but normal in adrenalectomized rats treated with corticosterone. They were also normal in animals injected i.P. with corticosterone 15 min before the stress but inhibited in those similarly treated 60 min previously.5. The ability of adenohypophyses and hypothalami to synthesize and release in vitro ACTH and CRH respectively in response to trophic stimuli was exaggerated in glands removed from adrenalectomized rats and reduced in those removed from corticosterone-treated rats.6. Addition of corticosterone to the pre-incubation medium reduced the capacities of adenohypophyses and hypothalami removed from untreated rats to synthesize and release ACTH and CRH respectively.

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The Effect of 'Training' on the Release of Corticotrophin in Response to Minor Stressful Procedures in the Rat

Cited by 38 publications

References 2 publications

Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

The influence of vasopressin on hypothalamic corticotrophin releasing activity in rats with inherited diabetes insipidus.

The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone

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