The Effect of Topical Use of Petroselinum Crispum (Parsley) Versus That of Hydroquinone Cream on Reduction of Epidermal Melasma

Khosravan, Shahla; Alami, Ali; Mohammadzadeh-Moghadam, Hossein; Ramezani, V.

doi:10.1097/hnp.0000000000000186

Cited by 20 publications

(22 citation statements)

References 7 publications

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“…These 12 studies included 695 patients with melasma from six different countries, in which female patients accounted for over 80%. Of 12 RCTs included, 2 studies included only epidermal melasma ( 29 , 34 ), three studies included epidermal and mixed melasma ( 23 , 25 , 31 ), 1 study included only mixed melasma ( 26 ), 1 study included all types of melasma ( 24 ), and five studies did not specify the types ( 27 , 28 , 30 , 32 , 33 ). The active ingredients contained in botanical products varied among trials as follows: herb-derived molecules, extracts of a single herb, and extracts of compound herbs.…”

Section: Resultsmentioning

confidence: 99%

“…The topical formulations of botanical products used for intervention included cream, oil, brewed, and solution. Six trials used placebo as a comparator ( 23 , 24 , 26 – 28 , 32 ), four trials used actives as a comparator ( 25 , 29 , 30 , 34 ), and two trials used both placebo and actives as a comparator ( 31 , 33 ). The duration of intervention ranged from 4 to 12 weeks with a maximum follow-up duration of 16 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…The duration of intervention ranged from 4 to 12 weeks with a maximum follow-up duration of 16 weeks. A total of seven trials reported the incidence of AEs ( 23 , 25 , 29 – 31 , 33 , 34 ). Of 12 RCTs included, four declared sponsorship from non-profit organizations ( 24 , 28 – 30 ), three from commercial industries ( 25 , 27 , 33 ), and five did not declare sponsorship ( 23 , 26 , 31 , 32 , 34 ).…”

Section: Resultsmentioning

confidence: 99%

“…Figure 2 shows the detailed assessment of the risk of bias. Of 12 RCTs included, 1 claimed unblinded ( 27 ), 2 claimed single-blind ( 23 , 25 ), 8 claimed double-blind ( 24 , 26 , 28 , 29 , 31 – 34 ), and 1 claimed triple-blind ( 30 ). Five studies arose concern for risk of bias for the following reasons ( 23 , 25 , 27 , 32 , 33 ): (1) one study used an odd-even randomization method; (2) two studies had insufficient information about randomization method; (3) four studies had insufficient information on allocation concealment; (4) three studies did not use adequate blind method; and (5) three studies were funded by commercial industries.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Wang

et al. 2022

Front. Med.

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Botanical products have been increasingly popular in topical therapies for melasma, as presumed safer and milder than fully synthetic products. Although the efficacy of different topical botanicals has recently been substantiated through randomized controlled trials (RCTs), there is a lack of sufficiently pooled evidence on their efficacy and safety for the treatment of melasma. Herein, a systematic review and meta-analysis was conducted on the efficacy and safety of topical botanical products for the treatment of melasma, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). All RCTs on the use of topical botanical products for the treatment of melasma in humans were included, except for trials enrolling pregnant patients. The primary outcome was Melasma Area and Severity Index (MASI) or its variation. The secondary outcomes included Mexameter® reading, melasma improvement evaluated by participants, and any reported adverse events (AEs). As a result, twelve eligible trials comprising 695 patients with melasma from 6 different countries were included. The topical botanical products contained active ingredients which varied among trials as follows: herb-derived molecule, extracts of a single herb, and extracts of compound herbs. Topical therapy with botanical products significantly improved melasma with a large effect on MASI reduction (SMD −0.79, 95% CI −1.14 to −0.44, p < 0.00001), and a moderate effect on Mexameter® reading reduction (SMD −0.52, 95% CI −0.81 to 0.23, p = 0.0005), when compared with placebo. It also showed a similar improvement of melasma with a better safety profile (RR 0.37, 95% CI 0.15–0.88, p = 0.02), when compared with active-comparators. Botanical products were well-tolerated across studies, with no serious AEs reported. Despite the limitations such as small sample size, short duration of follow up and varied botanical products, this work still represents the best level of evidence currently available on topical use of botanical products on melasma. Moreover, it should be noted that more well-designed studies are needed before recommending topical botanical products as a viable treatment option for melasma.Systematic Review RegistrationPROSPERO, identifier: CRD42021256328.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Wang

et al. 2022

Front. Med.

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“…101 Petroselinum crispum Petroselinum crispum, or English parsley, is a common food substance with hypoglycemic, hypolipidemic, hepatoprotective, diuretic, antimicrobial, anticoagulant, and antioxidant properties. 102 Khosravan et al 103 conducted a double-blind, randomized trial to assess the efficacy of topical petroselinum crispum compared with hydroquinone cream for melasma. Patients receiving either therapy achieved significant reductions in MASI score; however, there was no significant difference between groups.…”

Section: Plant Extracts Including Orchid Extractmentioning

confidence: 99%

Treatment of melasma: a review of less commonly used antioxidants

Babbush

Khachemoune

2020

Int J Dermatology

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Melasma, a common cause for seeking dermatologic care, is a chronic condition of skin hyperpigmentation. With a poorly understood pathogenesis, and no universal cure, melasma is a challenge for many dermatologists. For decades, there has been investigation into the role of oxidative stress in melasma. In this literature review, we introduce the role of oxidative stress in melasma and discuss the function of various topical and oral antioxidant therapies for patients suffering from melasma. Numerous studies have shown efficacy of various antioxidant therapies for treatment of hyperpigmentation, and in this review, we focus primarily on those with less widespread use. Vitamin E, niacinamide, polypodium leucotomos, pycnogenol, grape seed extract, amino fruit acids, phytic acid, zinc, silymarin, Korean red ginseng powder, plant extracts, and parsley all have well‐demonstrated evidence of antioxidant properties, and these substances have been studied in the context of skin hyperpigmentation. Although there is conflicting evidence of their therapeutic efficacy, the use of these naturally occurring substances is promising for patients and medical providers seeking alternative therapeutic options.

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Melasma hyperpigmentation: An overview of current topical therapeutics

AlSalem

Alexis

2022

Dermatological Reviews

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Background Melasma is a common disorder of hyperpigmentation that affects populations globally and can adversely affect quality of life. Topical therapies—including hydroquinone and nonhydroquinone‐containing formulations—play a central role in the management of melasma. Methods A literature review was conducted using PubMed and Google Scholar. Search keywords included a combination of the following: “melasma,” “chloasma,” and “topical treatment.” We identified and included seminal and high‐quality peer‐reviewed publications, systematic reviews, randomized controlled trials, case series, case reports, consensus statements, and expert opinions. Results Topical therapies are widely used for the treatment of melasma. Triple combination cream containing hydroquinone, fluocinolone, and tretinoin is the most studied formulation with the strongest evidence among treatment options. Numerous other prescription‐based and nonprescription topical agents, including a growing list of cosmeceuticals, have been used in the treatment of melasma, albeit in smaller studies. Conclusion A growing range of topical agents is available for the treatment of melasma. While larger, more robust studies are warranted, nonhydroquinone cosmeceuticals may be useful adjuncts or alternatives to the gold standard of triple‐combination hydroquinone cream.

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The Effect of Topical Use of Petroselinum Crispum (Parsley) Versus That of Hydroquinone Cream on Reduction of Epidermal Melasma

Cited by 20 publications

References 7 publications

Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Treatment of melasma: a review of less commonly used antioxidants

Melasma hyperpigmentation: An overview of current topical therapeutics

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