The effect of toothpastes containing hydroxyapatite, fluoroapatite, and Zn-Mg-hydroxyapatite nanocrystals on dentin hypersensitivity: A randomized clinical trial

Abstract

A BSTRACT Aims: The aim of this study was to compare the effect of toothpastes containing hydroxyapatite (nHAP), Zn-Mg-hydroxyapatite (nZnMgHAP), and fluorapatite (nFAP) nanocrystals on dentin hypersensitivity (DH) associated with noncarious cervical lesions. Materials and Methods: Thirty consenting volunteers aged 35−45 years with DH were enrolled in a double-blind, parallel study, randomly assigned to the nHAP group ( n = 10), the nZnMgHAP group ( n = 10), or the nFAP group ( n = 10), and instructed to use the toothpaste twice daily for one month. The primary outcome was Schiff scores at baseline and after 2 and 4 weeks. Results: All patients fulfilled the study requirements, and no adverse effects were registered. A reduction in DH was registered in 90%, 100%, and 50% of patients using nHAP, nZnMgHAP, and nFAP-containing toothpastes with effect sizes 2.52 (confidence interval [CI] 95%: 0.82, 4.14), 3.30 (CI 95%: 1.33, 5.20), and 1.44 (CI 95%: 0.09, 2.72), respectively. At 4 weeks, Schiff index scores decreased significantly in all groups compared to baseline. Conclusions: nZnMgHAP may be considered a promising agent for DH management.

The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review

“…A total of 7515 articles were excluded after reading titles and/or abstracts, 12 records were excluded since reports were not retrieved, 57 records from database registers and 18 identified through other methods were read and analyzed in their full-text, and 55 records were excluded for reasons such as not good drugs tested ( n = 34), in vitro studies ( n = 11), or study on tooth decay ( n = 10), as shown in Figure 1 . Twenty records met the inclusion criteria and were included in the systematic review: Poliakova et al, 2022 [ 30 ], Alharith et al, 2021 [ 31 ], Amaechi et al, 2021 [ 32 ], Eyuboglu et al, 2020 [ 33 ], Usai et al, 2019 [ 34 ], Amaechi et al, 2018 [ 35 ], Ameen et al, 2018 [ 36 ], Anand et al, 2018 [ 37 ], Vano et al, 2017 [ 38 ], De Oliveira et al, 2016 [ 39 ], Wang et al, 2016 [ 40 ], Gopinath et al, 2015 [ 41 ], Jena et al, 2015 [ 42 ], Mehta et al, 2015 [ 43 ], Naoum et al, 2015 [ 44 ], Mehta et al, 2014 [ 45 ], Porciani et al, 2014 [ 46 ], Vano et al, 2014 [ 47 ], Ghassemi et al, 2009 [ 48 ], and Geiger et al, 2003 [ 49 ]. The selection process has been detailed in the attached PRISMA flowchart ( Figure 1 ).…”

“…The follow-up range varied from immediately to 6 months. Most of the studies performed a 4-week follow-up phase [ 30 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 47 , 48 , 49 ].…”

“…Molecules were tested in the form of toothpaste, gel, or chewing gum and administered through an in-office treatment in 10 studies [ 31 , 33 , 34 , 35 , 36 , 39 , 42 , 43 , 45 , 49 ]. In the other 10 studies, the treatment was performed by the patients themselves, at home [ 30 , 32 , 37 , 38 , 40 , 41 , 44 , 46 , 47 , 48 ]. Most of the included studies used another desensitizing agent as a control [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 48 ], and four studies used only a placebo as a control [ 43 , 46 , 47 , 49 ].…”

“…In the other 10 studies, the treatment was performed by the patients themselves, at home [ 30 , 32 , 37 , 38 , 40 , 41 , 44 , 46 , 47 , 48 ]. Most of the included studies used another desensitizing agent as a control [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 48 ], and four studies used only a placebo as a control [ 43 , 46 , 47 , 49 ].…”

“…In all included studies, dentin hypersensitivity was evaluated with an air blast test, tactile test, or cool water test, in accordance with the guidelines described by Holland et al, 1997 [ 2 ]. These guidelines, recommending at least two tests, were respected by most of the studies, except for [ 30 , 40 , 48 ], which only used an air blast test. The majority of studies realized an air blast assessment (evaporative stimulus) associated with a tactile sensitivity test [ 31 , 33 , 34 , 36 , 38 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 49 ].…”