The Effect of Tilmicosin and Apramycin Alone or Together in Treatment of Experimentally Infected Chickens With Mycoplasma Gallisepticum Only or With Escherichia Coli

Abstract

Mycoplasmosis remains one of the most expensive and common diseases facing poultry industry. The presence of Mycoplasma gallisepticum (MG) predisposes birds to other infections asEscherichia coli which together causes mortality, and sub-optimal performance. Therefore, this study was carried out to evaluate the efficacy of tilmicosin, apramycin and both drugs together on experimentally infected chicken with local field isolates of MG only or with E. coli as CRD and CCRD treatments. The present investigation clarified that infected groups treated with both tilmicosin and apramycin showed additive or synergistic interaction between them, which in turn confirmed the safety use of this combination therapy. The use of the recommended therapeutic dose of tilmicosin (1ml/L) or apramycin (0.5gm/L) alone or in combination for 5 successive days after appearance of the clinical signs are of considerable value in the treatment of MG infection in broiler chickens as antimycoplasmal drugs through displayed valuable improvement in clinical symptoms, survival rate, lesion scoring and termination of infection by the mycoplasmacidal effect of both drugs. The results also indicated that combined tilmicosin-apramycin therapy as antimicrobial drugs givesThe Effect Of Tilmicosin And Apramycin Alone Or ...