The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves’ disease and active thyroid-associated orbitopathy

Londzin-Olesik, Magdalena; Kos–Kudła, Beata; Nowak, Agnieszka; Wielkoszyński, Tomasz; Nowak, Mariusz

doi:10.5603/ep.a2020.0049

Cited by 9 publications

(16 citation statements)

References 44 publications

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“…It has been reported that the thyroid hormone, like autoimmune in ammation, is a signi cant contributor to oxidative stress in patients with TAO, which manifests as upregulated lipid peroxidation and antioxidant system activation [21,22]. It is found that euthyroid state restoration leads to a relative reduction in activity and levels of most antioxidant parameters [23,24]. Thus, the autoimmune in ammation of the orbital tissue and thyroid hormone status seem to be mutually independent modi ers of TAO activity which may explain the fact that CAS score is related to hormone levels.…”

Section: Discussionmentioning

confidence: 99%

Using The Random Forest Algorithm To Detect The Activity of Thyroid-Associated Ophthalmopathy

Wang

Zhang

et al. 2021

Preprint

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Objective: The aim of this study is to establish a random forest model to detect active and quiescent phases of patients with Thyroid-associated ophthalmopathy (TAO) and to evaluate its diagnostic performance.Methods：A total of 146 patients (292 eyes) who were diagnosed with TAO and were treated in the Ophthalmology Outpatient Clinic of Beijing TongRen hospital were retrospectively included in the study. We took the clinical activity score of TAO as the target; took gender, age, smoking status, I-131 treatment history, thyroid nodules, thyromegaly, thyroid hormone and TSH-receptor antibodies (TRAb) as predictive characteristic variables to establish a random forest model. The proportion of the training group to the testing group was 7:3. We analyzed the model’s accuracy, precision, sensitivity, specificity, positive predictive value (PPV), negative predictive value (PPV), F1 score and out-of-bag (OOB) error, with the accuracy, the brier loss and the area under the receiver operating characteristic curve compared with logistic regression model.Results：Our model has an accuracy of 0.93, a sensitivity of 0.88, a specificity of 0.96, a positive predictive value of 0.94, a negative predictive value of 0.93, an F1 score of 0.91 and an OOB error of 0.12. The accuracy of the random forest model and the logistic regression model were 0.93 and 0.79, respectively, the brier loss were 0.06 and 0.20, and the area under the receiver operating characteristic curve were 0.95 and 0.86.Conclusion：By integrating these high-risk factors, the random forest algorithm can be used as a complementary diagnostic method to determine the activity of TAO, showing prominent diagnostic performance.

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Section: Discussionmentioning

confidence: 99%

Using The Random Forest Algorithm To Detect The Activity of Thyroid-Associated Ophthalmopathy

Wang

Zhang

et al. 2021

Preprint

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“…Finally, 20 papers met the inclusion criteria and were considered in this review [ Figure 1 ]. There were four human studies 20 21 22 23 and sixteen in vitro studies 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 from 1993 to 2021 [ Table 2 ]. Fifteen studies were from Taiwan (2), Canada (1), Greece (1), Brazil (2), Poland (1), the USA (1), Japan (1), Italy (5), South Korea (3), Germany (1), China (1), and one was supervised by the international multicentral European Group on Graves' Orbitopathy (EUGOGO) association.…”

Section: R Esultsmentioning

confidence: 99%

A systematic review on the role of antioxidants in thyroid eye disease

et al. 2022

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“…Bednarek et al reported elevated blood levels of H 2 O 2 , lipid hydroperoxide (ROOH), TBARS, and ceruloplasmin as well as increased SOD and CAT activities but reduced GPx and glutathione reductase activities in patients with GD [ 24 , 33 ]. These parameters were normalized after achieving euthyroidism in the study population except those with GO, indicating that the contribution of orbital inflammation to oxidative stress was independent of thyroid hormones [ 33 , 51 ].…”

Section: In Vivo Evidence Of Oxidative Stress In Graves’ Ophthalmopathymentioning

confidence: 99%

“…In addition, 6.25 μM H 2 O 2 upregulated TGF-β1, IL-1β, and O 2 •− in orbital fibroblasts from patients with GO [ 28 ]. It is believed that IL-1β induces inflammatory cytokines and that TGF-β1 promotes tissue remodeling and fibrosis through myofibroblast transdifferentiation in GO orbital fibroblasts [ 51 , 53 ]. These processes are critical in the pathogenesis of GO.…”

Section: In Vitro Evidence On Oxidative Stress In Graves’ Ophthalmopathymentioning

confidence: 99%

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy

Hou

Kau

et al. 2021

Biomedicines

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Graves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. It is characterized initially by an inflammatory process, followed by tissue remodeling and fibrosis, leading to proptosis, exposure keratopathy, ocular motility limitation, and compressive optic neuropathy. The pathogenic mechanism is complex and multifactorial. Accumulating evidence suggests the involvement of oxidative stress in the pathogenesis of GO. Cigarette smoking, a major risk factor for GO, has been shown to induce reactive oxygen species (ROS) generation and oxidative damage in GO orbital fibroblasts. In addition, an elevation in ROS and antioxidant enzymes is observed in tears, blood, and urine, as well as orbital fibroadipose tissues and fibroblasts from GO patients. In vitro and in vivo studies have examined the efficacy of various antioxidant supplements for GO. These findings suggest a therapeutic role of antioxidants in GO patients. This review summarizes the current understanding of oxidative stress in the pathogenesis and potential antioxidants for the treatment of GO.

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The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves’ disease and active thyroid-associated orbitopathy

Cited by 9 publications

References 44 publications

Using The Random Forest Algorithm To Detect The Activity of Thyroid-Associated Ophthalmopathy

Using The Random Forest Algorithm To Detect The Activity of Thyroid-Associated Ophthalmopathy

A systematic review on the role of antioxidants in thyroid eye disease

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy

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