The Effect of Thyroid Disorders on Lipid Levels and Metabolism

Duntas, Leonidas H.; Brenta, Gabriela

doi:10.1016/j.mcna.2012.01.012

Cited by 193 publications

(174 citation statements)

References 87 publications

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“…Other studies have also reported similar findings. [8][9][10]17,19 We also observed a higher prevalence of diastolic hypertension in hypothyroid patients (64.3%) compared to euthyroid patients (34.9%). Similar results were obtained in other studies also.…”

Section: Discussionsupporting

confidence: 59%

Study on prevalence of hypothyroidism in ST segment elevation myocardial infarction

Sreevidya

Renymol

2017

Int J Res Med Sci

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Background: Both subclinical and overt hypothyroidism have effects on myocardial contractility and cardiovascular haemodynamics. In addition, changes in lipids, low levels of inflammation, elevated homocysteine etc. contribute to accelerated atherosclerosis and increased cardio vascular mortality and morbidity in hypothyroidism. In this study, we tried to find out the prevalence of hypothyroidism in patients admitted with acute ST elevation myocardial infarction. We also tried to assess the BMI, diastolic BP and lipid profile of these patients.Methods: A cross sectional study was done among patients admitted with ST elevation myocardial infarction in Coimbatore Medical College, Coimbatore, Tamil Nadu, India. We collected information on BMI, blood pressure, lipid profile and thyroid function of these patients.Results: The prevalence of hypothyroidism was found to be 14% in patients admitted with ST elevation MI. Hypothyroidism was three times more common in women. Patients with hypothyroidism was found to have higher BMI, elevated total cholesterol, triglycerides and LDL which was statistically significant. Higher prevalence of diastolic hypertension was also seen among hypothyroid patients.Conclusions: Thyroid hormone has various actions on heart. Hypothyroidism has increased cardiovascular morbidity and mortality. The associated risk factors like obesity, hyperlipidaemia and diastolic hypertension contribute to this. Patients with coronary artery disease should be screened for hypothyroidism.

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Section: Discussionsupporting

confidence: 59%

Study on prevalence of hypothyroidism in ST segment elevation myocardial infarction

Sreevidya

Renymol

2017

Int J Res Med Sci

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“…Thyroid hormone has multiple effects on the lipid synthesis and metabolism, and overt hypothyroidism is consistently associated to lipid abnormalities which are reversible with levothyroxine therapy (135,136) (D,D), but this relationship is controversial in patients with SH (4) (D).…”

Section: Is There An Association Between Dyslipidemia and Subclinicalmentioning

confidence: 99%

“…Multiple interventional studies have evaluated the effects of levothyroxine on lipid profiles in patients with SH, with mixed results (135,136) (D,D). A meta-analysis of 13 studies (141) (B) found a significant decrease of serum total cholesterol levels following levothyroxine therapy, mainly in patients with elevated cholesterol values, but most of the selected studies had a non-randomized design.…”

Section: Is There An Association Between Dyslipidemia and Subclinicalmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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“…However, whether this association is related to SCH-induced changes in the serum lipid profile or other classical cardiovascular (CV) risk factors remains unclear (15,16). Some studies have found that subjects with SCH have higher serum total cholesterol (TC) and LDL cholesterol (LDL-C) levels compared with euthyroid (EU) subjects (17,18). Despite these findings, the impact of L-T 4 replacement on this endpoint, especially in the setting of mild thyroid dysfunction, has been somewhat conflicting in several studies (19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification, especially in subjects with intermediate and high cardiovascular risk scores

Silva¹,

Santos²,

Morais³

et al. 2014

European Journal of Endocrinology

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Objective: Several studies have suggested an association between subclinical hypothyroidism (SCH) and increased cardiovascular risk. The aim of this study was to evaluate the presence of coronary artery disease (CAD) in asymptomatic patients with SCH by measuring the coronary artery calcium score (CACS). Design: A total of 222 asymptomatic subjects (103 SCH and 119 euthyroid (EU)), who were between the ages of 35 and 65 years and had no previous history of CAD, were enrolled for this cross-sectional analysis. Methods: The criteria for SCH included a confirmed normal serum free thyroxine and high TSH levels. Lipid profile, Framingham risk score (FRS) and CACS analyses were performed for all subjects. Results: The SCH and EU groups were comparable with respect to age, gender, BMI and frequency of diabetes, systemic arterial hypertension, hypercholesterolaemia and smoking. There was no difference in the median CACS between the SCH and EU groups. However, in the subgroup of subjects with intermediate/high FRS (AR 10y R10%), CACS was higher in the SCH subjects compared with EU subjects (EU vs SCH, 0.0 (57.0) vs 23.0 (161.5); PZ0.045). Multivariate analysis revealed that the risk for CACS O100 was independently associated with male gender, age O55 years, and the presence of simultaneous SCH and AR 10y R10% (ORZ87.5 (CIZ2.1-3500); PZ0.001). Serum TSH was positively correlated with CACS, especially in intermediate/high FRS subjects (r s Z0.301, PZ0.045). Conclusions: It was demonstrated that SCH represents an additional risk factor for CAD, notably in intermediate and high FRS subjects.

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The Effect of Thyroid Disorders on Lipid Levels and Metabolism

Cited by 193 publications

References 87 publications

Study on prevalence of hypothyroidism in ST segment elevation myocardial infarction

Study on prevalence of hypothyroidism in ST segment elevation myocardial infarction

Clinical practice guidelines for the management of hypothyroidism

Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification, especially in subjects with intermediate and high cardiovascular risk scores

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