The effect of thyrocalcitonin and growth hormones on bone metabolism

Klein, Ira E.

doi:10.1016/s0022-3913(75)80032-1

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…Additionally, GH has been demonstrated to improve calcium absorption and vitamin D levels ( 12 ). In previous in vivo studies with small animal models, the systemic administration of GH significantly increased different osseointegration parameters of endosteal implants in osteoporotic subjects ( 8 , 13 - 17 ). GH has also been suggested to have a local effect on bone remodeling through the stimulation of the synthesis of collagen, osteocalcin and alkaline phosphatase.…”

Section: Introductionmentioning

confidence: 79%

“…Such stimulation may result in increased osseoconductibility, enhanced mineral deposition, and subsequently, expediated, predicTable, long-lasting osseointegration ( 5 - 7 ). Growth hormone (GH), a 70 amino acid polypeptide chain originating from the pituitary gland, has demonstrated to have a significant impact in both osteoblast and osteoclast activity ( 8 , 9 ). Furthermore, it has been suggested to positively influence new bone formation and increase the cortical bone mass during bone regeneration procedures ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

Grossi¹,

Parra²,

Jalkh³

et al. 2022

Med Oral

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Background The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant’s surface at the early stages of osseointegration. Material and Methods Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Results Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant’s threads. Conclusions A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time. Key words: Growth hormone, osseointegration, low density bones, metallic implants, sheep, bone-to-implant contact.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

Grossi¹,

Parra²,

Jalkh³

et al. 2022

Med Oral

View full text Add to dashboard Cite

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Genetic and environmental correlations between bone phenotypes and anthropometric indices in Chinese

et al. 2005

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Height, weight, bone mineral density (BMD), and bone size are all influenced by genetic and environmental factors as well as interactions between them. Height and weight are often used in population studies to adjust the bone phenotypes. However, it is still unknown what proportion of genetic and environmental variability is shared between these anthropometric characteristics and the bone phenotypes. The genetic and environmental correlations between the bone phenotypes and anthropometric indices in Chinese subjects were studied by bivariate quantitative genetic analysis on a sample of 931 healthy subjects from 292 Chinese nuclear families aged from 19 to 79 years. BMD and bone size at the lumbar spine (L1-L4) and the hip of all subjects were measured by dual-energy X-ray absorptiometry. We found significant genetic correlations between weight and spine BMD, hip BMD, spine bone size and hip bone size, which were 0.50 (P<0.01), 0.45 (P<0.01), 0.36 (P=0.02), and 0.38 (P<0.01), respectively. Likewise, significant genetic correlations between height and spine BMD, spine bone size, and hip bone size were 0.30 (P=0.02), 0.54 (P<0.01), and 0.58 (P<0.01), respectively. The environmental correlations were found to be significant only between height and spine bone size (P<0.001) and weight and hip BMD (P=0.02). These results suggest the probability that the same genetic and environmental factors contribute to these different phenotypes. Moreover, when a candidate gene or genomic region is responsible for the variation of both bone phenotypes and anthropometric indices, its true genetic effect on the bone phenotypes may be lost after one has adjusted the phenotypic values with weight and height as random environmental factors. It may have implications for population studies of candidate genes that underlie the complex bone phenotypes and for the development of strategies for therapeutic application.

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Report of the committee on scientific investigation of the American Academy of Restorative Dentistry

Charbeneau¹,

Lund²,

Phillips³

et al. 1976

The Journal of Prosthetic Dentistry

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The effect of thyrocalcitonin and growth hormones on bone metabolism

Cited by 7 publications

References 7 publications

Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

Genetic and environmental correlations between bone phenotypes and anthropometric indices in Chinese

Report of the committee on scientific investigation of the American Academy of Restorative Dentistry

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