The effect of thymoquinone and propranolol combination on epidermoid laryngeal carcinoma cell

Şahin, Caner; Maytalman, Erkan; Samur, Dilara Nemutlu; Doğan, Bora

doi:10.1007/s00405-023-07825-0

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particular attention is currently being paid to research into the anticancer effects of TQ. Thymoquinone has anticancer properties that have been confirmed in preclinical studies of many types of cancer, including ovarian, colon, laryngeal, breast, leukemia, lung and osteosarcoma [67][68][69][70][71][72][73][74][75][76]. Currently, there is only one clinical trial evaluating the chemopreventive effect of thymoquinone on potentially malignant oral lesions in the clinicaltrials.gov database (accessed 14 November 2023).…”

Section: Preclinical and Clinical Studies On Thymoquinone And Its Mai...mentioning

confidence: 99%

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Kurowska,

Madej,

Strzalka-Mrozik

2023

CIMB

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and is responsible for approximately one million deaths each year. The current standard of care is surgical resection of the lesion and chemotherapy with 5-fluorouracil (5-FU). However, of concern is the increasing incidence in an increasingly younger patient population and the ability of CRC cells to develop resistance to 5-FU. In this review, we discuss the effects of thymoquinone (TQ), one of the main bioactive components of Nigella sativa seeds, on CRC, with a particular focus on the use of TQ in combination therapy with other chemotherapeutic agents. TQ exhibits anti-CRC activity by inducing a proapoptotic effect and inhibiting proliferation, primarily through its effect on the regulation of signaling pathways crucial for tumor progression and oxidative stress. TQ can be used synergistically with chemotherapeutic agents to enhance their anticancer effects and to influence the expression of signaling pathways and other genes important in cancer development. These data appear to be most relevant for co-treatment with 5-FU. We believe that TQ is a suitable candidate for consideration in the chemoprevention and adjuvant therapy for CRC, but further studies, including clinical trials, are needed to confirm its safety and efficacy in the treatment of cancer.

show abstract

Section: Preclinical and Clinical Studies On Thymoquinone And Its Mai...mentioning

confidence: 99%

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Kurowska,

Madej,

Strzalka-Mrozik

2023

CIMB

View full text Add to dashboard Cite

show abstract

The effect of thymoquinone and propranolol combination on epidermoid laryngeal carcinoma cell

Cited by 1 publication

References 31 publications

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Contact Info

Product

Resources

About